Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0001490
UniProt IDP17535
Primary gene name(s)JUND
Synonym gene name(s)unknown
Protein nameTranscription factor jun-D
Protein functionTranscription factor binding AP-1 sites. {ECO:0000269|PubMed:9989505}.
Subcellular locationNucleus.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P17535
Gene Ontology
(Biological Process)
Complete annatation
aging [GO:0007568];
cellular response to calcium ion [GO:0071277];
cellular response to hormone stimulus [GO:0032870];
circadian rhythm [GO:0007623];
negative regulation of transcription from RNA polymerase II promoter [GO:0000122];
osteoblast development [GO:0002076];
positive regulation of cell differentiation [GO:0045597];
positive regulation of osteoblast differentiation [GO:0045669];
positive regulation of transcription from RNA polymerase II promoter [GO:0045944];
regulation of cell cycle [GO:0051726];
regulation of cell death [GO:0010941];
regulation of cell proliferation [GO:0042127];
regulation of transcription from RNA polymerase II promoter [GO:0006357];
response to cAMP [GO:0051591];
response to cytokine [GO:0034097];
response to drug [GO:0042493];
response to light stimulus [GO:0009416];
response to lipopolysaccharide [GO:0032496];
response to mechanical stimulus [GO:0009612];
response to peptide hormone [GO:0043434];
response to radiation [GO:0009314];
transcription from RNA polymerase II promoter [GO:0006366]
Gene Ontology
(Molecular Function)
Complete annatation
enzyme binding [GO:0019899];
RNA polymerase II core promoter proximal region sequence-specific DNA binding [GO:0000978];
RNA polymerase II transcription factor activity, sequence-specific DNA binding [GO:0000981];
transcription coactivator activity [GO:0003713];
transcription factor binding [GO:0008134];
transcription regulatory region DNA binding [GO:0044212]
Gene Ontology
(Cellular Component)
Complete annatation
chromatin [GO:0000785];
nuclear chromatin [GO:0000790];
nucleus [GO:0005634];
protein-DNA complex [GO:0032993];
transcription factor complex [GO:0005667]
Protein-protein interaction109930
Phylogenetic treeP17535
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-0.2009302364141170.5472692249794690.659453290605257
AZA vs. DISU-0.4903848673792470.1991136032441110.78864353066485
AZA vs. IL7-0.3101958770296760.2881951196089580.999311006273513
AZA vs. SAHA-0.8733305060129370.00367136821538860.0503442568223692
DISU vs. CD3-0.2997055303101070.4719756236750270.600030408305419
DISU vs. IL70.1696605521577250.6549413386283450.901215099517406
DISU vs. SAHA-0.3799286528608550.3230010900777050.705909139872547
DMSO vs. AZA-0.3285995272969910.35835403557471
DMSO vs. CD3-0.1290794760803480.7501556436890710.819097975804584
DMSO vs. DISU0.162742437878760.7084684059938010.960763093481455
DMSO vs. IL70.0245153506301730.9456151403463250.990253973369612
DMSO vs. SAHA-0.5516552167732110.1336608330119760.438485505947647
HIV vs. Mock in Activation0.6014666548921320.3407687711767980.999983755607037
HIV vs. Mock in Latency-0.2456332054438450.1781310073177560.999834320637052
IL7 vs. CD3-0.1058112529863950.7451736021332120.829542223408708
SAHA vs. CD3-0.6937531827786180.0509886826150210.10064170884196
SAHA vs. IL7-0.5644906987783680.05859281624904510.203953339052936
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) TRUE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.0440822 0.810219
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
0.944 0.757 0.463 0.588 0.545
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
203751_x_at 1.65 No downregulated in CD8+ cells
214326_x_at 1.74 No downregulated in CD8+ cells

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
3U86 X-ray 2.8Å B=27-39.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Vpu activates 24551192

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04010 MAPK signaling pathway - Homo sapiens (human)
hsa04380 Osteoclast differentiation - Homo sapiens (human)
hsa04657 IL-17 signaling pathway - Homo sapiens (human)