Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0001488
UniProt IDO76095
Primary gene name(s)JTB
Synonym gene name(s)unknown
Protein nameProtein JTB
Protein functionRequired for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex, CPC, a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity. Inhibits apoptosis induced by TGFB1, By similarity. Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential, By similarity. {ECO:0000250, ECO:0000269|PubMed:21225229}.
Subcellular locationMembrane {ECO:0000305};
Single-pass type I membrane protein {ECO:0000305}. Mitochondrion {ECO:0000250}. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Detected at the centrosome and along spindle fibers during prophase and metaphase. Detected at the midbody during telophase.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: O76095
Gene Ontology
(Biological Process)
Complete annatation
apoptotic mitochondrial changes [GO:0008637];
cytokinesis [GO:0000910];
mitotic nuclear division [GO:0007067];
positive regulation of protein kinase activity [GO:0045860];
regulation of cell proliferation [GO:0042127]
Gene Ontology
(Molecular Function)
Complete annatation
protein kinase binding [GO:0019901]
Gene Ontology
(Cellular Component)
Complete annatation
cytoplasm [GO:0005737];
integral component of plasma membrane [GO:0005887];
membrane [GO:0016020];
microtubule organizing center [GO:0005815];
midbody [GO:0030496];
mitochondrion [GO:0005739];
spindle [GO:0005819]
Protein-protein interaction116105
Phylogenetic treeO76095
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
      unknown
Brass et al., Science, 2008
      unknown
Smith et al., J. Immunol, 2010
      unknown
Interferon-stimulated
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model


DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD30.419463238086640.2002811173086690.305148393024377
AZA vs. DISU-0.07207085485510820.7754819995030360.976444104025318
AZA vs. IL7-0.003514069341378710.9854054306625530.999311006273513
AZA vs. SAHA-0.1869971239851120.4434397516087750.788183866617569
DISU vs. CD3-0.5038194638138880.1648898412273630.274616005597313
DISU vs. IL70.05922954438562060.8139397897235330.960029913941183
DISU vs. SAHA-0.1127209561806550.6988482433976290.910635902970964
DMSO vs. AZA-0.092614578980160.5802030506203751
DMSO vs. CD3-0.5246281724434480.1013161572406570.172739690904312
DMSO vs. DISU-0.02263344048811250.9260279455959580.99025820832269
DMSO vs. IL70.09656351829535880.5910021997788950.909845858619163
DMSO vs. SAHA-0.09969841143218650.672236775294970.897786781843686
HIV vs. Mock in Activation-0.1508063365668370.8089220316763640.999983755607037
HIV vs. Mock in Latency-0.01669639419942220.91936373735880.999834320637052
IL7 vs. CD3-0.4163867875918040.194996486786940.316517558188622
SAHA vs. CD3-0.6303772574585690.07529661533410530.138735785925537
SAHA vs. IL7-0.1862397281668230.4443421531489060.684099031413196
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) FALSE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.255702 0.192456
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
0.991 0.891 0.863 0.953 0.823
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
2KJX NMR - A=47-104.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
not found
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