Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0001483
UniProt IDQ15652
Primary gene name(s)JMJD1C
Synonym gene name(s)JHDM2C, KIAA1380, TRIP8
Protein nameProbable JmjC domain-containing histone demethylation protein 2C
Protein functionProbable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, By similarity. {ECO:0000250}.
Subcellular locationNucleus {ECO:0000250}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q15652
Gene Ontology
(Biological Process)
Complete annatation
blood coagulation [GO:0007596];
histone H3-K9 demethylation [GO:0033169];
regulation of transcription, DNA-templated [GO:0006355];
transcription, DNA-templated [GO:0006351]
Gene Ontology
(Molecular Function)
Complete annatation
dioxygenase activity [GO:0051213];
histone demethylase activity, H3-K9 specific [GO:0032454];
metal ion binding [GO:0046872];
thyroid hormone receptor binding [GO:0046966]
Gene Ontology
(Cellular Component)
Complete annatation
intracellular [GO:0005622];
nucleoplasm [GO:0005654]
Protein-protein interaction128677
Phylogenetic treeQ15652
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-0.7374346285122620.02520540750081470.0563309463007531
AZA vs. DISU0.3311080972998460.1915756881083990.778706964639598
AZA vs. IL7-0.1415981259319530.4614701551245130.999311006273513
AZA vs. SAHA0.1521909731283090.5326138042579040.83884865587542
DISU vs. CD31.054924907692430.004233611889193250.014125158392585
DISU vs. IL7-0.4811898889393060.05695011357916620.314347303232576
DISU vs. SAHA-0.1783092642573940.5420079456619730.846842196149057
DMSO vs. AZA-0.03426918382954720.8379187509917891
DMSO vs. CD30.6908262825621160.03168077284756510.0657296717624088
DMSO vs. DISU-0.3675447167453910.1329790652081890.623975061846561
DMSO vs. IL7-0.09994920630179550.578340634896770.905672503991634
DMSO vs. SAHA0.1789182187017270.4478124457731110.779598171450451
HIV vs. Mock in Activation-0.06099005761277630.9226127707100330.999983755607037
HIV vs. Mock in Latency-0.001686622035862730.9918375830922240.999834320637052
IL7 vs. CD30.6049273998660670.06097811367429580.12905407293073
SAHA vs. CD30.8636034639684350.01517609489208520.0364816956490227
SAHA vs. IL70.289157625653660.2353514240806470.476234397775015
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) TRUE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.679925 0.859653
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
0.987 1.077 0.933 0.937 1.08
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
221763_at 1.74 No downregulated in CD8+ cells

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
2YPD X-ray 2.1Å A/B=2157-2540.
5FZO X-ray 1.8Å A/B=2157-2500.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa05202 Transcriptional misregulation in cancer - Homo sapiens (human)