Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0001481
UniProt IDQ86VZ6
Primary gene name(s)JAZF1
Synonym gene name(s)TIP27, ZNF802
Protein nameJuxtaposed with another zinc finger protein 1
Protein functionActs as a transcriptional corepressor of orphan nuclear receptor NR2C2, PubMed:15302918. Inhibits expression of the gluconeogenesis enzyme PCK2 through inhibition of NR2C2 activity, By similarity. Also involved in transcriptional activation of NAMPT by promoting expression of PPARA and PPARD, By similarity. Plays a role in lipid metabolism by suppressing lipogenesis, increasing lipolysis and decreasing lipid accumulation in adipose tissue, By similarity. Plays a role in glucose homeostasis by improving glucose metabolism and insulin sensitivity, By similarity. {ECO:0000250|UniProtKB:Q80ZQ5, ECO:0000269|PubMed:15302918}.
Subcellular locationNucleus {ECO:0000269|PubMed:15302918}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q86VZ6
Gene Ontology
(Biological Process)
Complete annatation
lipid metabolic process [GO:0006629];
negative regulation of transcription from RNA polymerase II promoter [GO:0000122];
transcription, DNA-templated [GO:0006351]
Gene Ontology
(Molecular Function)
Complete annatation
metal ion binding [GO:0046872];
nucleic acid binding [GO:0003676];
transcription corepressor activity [GO:0003714]
Gene Ontology
(Cellular Component)
Complete annatation
cytoplasm [GO:0005737];
nucleolus [GO:0005730];
nucleus [GO:0005634];
transcriptional repressor complex [GO:0017053]
Protein-protein interaction128764
Phylogenetic treeQ86VZ6
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
      unknown
Brass et al., Science, 2008
      unknown
Smith et al., J. Immunol, 2010
      unknown
Interferon-stimulated
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model


DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD30.04259232245757980.8987728771851540.934550176263169
AZA vs. DISU0.0689135567996330.789999579412210.980447216724869
AZA vs. IL7-0.08344558795604930.6734232553068990.999311006273513
AZA vs. SAHA0.1288269773010180.6050441318381360.869780430764322
DISU vs. CD30.01402191170903710.9693153024233970.980995835843455
DISU vs. IL7-0.1597485753901610.5340939844508120.845692668620275
DISU vs. SAHA0.06066934773197140.8367407172471180.957937888454383
DMSO vs. AZA-0.09783572338880310.5791565675417141
DMSO vs. CD3-0.1528150756981530.6399918173483590.730747061418299
DMSO vs. DISU-0.1686777579043720.4992291209867280.907707163836772
DMSO vs. IL70.02180011309146350.9064949576265330.980205121221583
DMSO vs. SAHA0.2196511832340030.3614653770658360.709384598439679
HIV vs. Mock in Activation-0.4284621918001620.4961444125546780.999983755607037
HIV vs. Mock in Latency0.03634640848293650.832578353282280.999834320637052
IL7 vs. CD3-0.1156057729805360.723714991303420.814132104180644
SAHA vs. CD30.06106375811794460.8640427085916280.904244695727488
SAHA vs. IL70.2072502259199450.4034120989824380.650169355293625
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock 0.92 6.05E-11 1.10E-08
Infected vs. Bystander 0.921 5.92E-11 5.80E-09
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) TRUE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -0.0442693 0.82453
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
not found
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