Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0001473
UniProt IDQ14571
Primary gene name(s)ITPR2
Synonym gene name(s)unknown
Protein nameInositol 1,4,5-trisphosphate receptor type 2
Protein functionReceptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA, By similarity. {ECO:0000250|UniProtKB:Q9Z329}.
Subcellular locationEndoplasmic reticulum membrane;
Multi-pass membrane protein.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q14571
Gene Ontology
(Biological Process)
Complete annatation
cellular response to cAMP [GO:0071320];
cellular response to ethanol [GO:0071361];
platelet activation [GO:0030168];
regulation of cardiac conduction [GO:1903779];
regulation of insulin secretion [GO:0050796];
response to hypoxia [GO:0001666];
signal transduction [GO:0007165];
transport [GO:0006810]
Gene Ontology
(Molecular Function)
Complete annatation
calcium ion transmembrane transporter activity [GO:0015085];
inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [GO:0005220];
phosphatidylinositol binding [GO:0035091]
Gene Ontology
(Cellular Component)
Complete annatation
cell cortex [GO:0005938];
endoplasmic reticulum membrane [GO:0005789];
integral component of membrane [GO:0016021];
membrane [GO:0016020];
plasma membrane [GO:0005886];
platelet dense tubular network membrane [GO:0031095];
receptor complex [GO:0043235];
sarcoplasmic reticulum membrane [GO:0033017]
Protein-protein interaction109914
Phylogenetic treeQ14571
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
      unknown
Brass et al., Science, 2008
      unknown
Smith et al., J. Immunol, 2010
      unknown
Interferon-stimulated
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model


DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-0.7231187543302960.02803549341775310.0615335600396644
AZA vs. DISU-0.04416865884971140.8615446090339730.991133096247651
AZA vs. IL7-0.02224154768784060.9079554662209970.999311006273513
AZA vs. SAHA-0.05161750101146120.8328966516691940.959845248930506
DISU vs. CD30.6664350459569410.06698338799899540.136539227950893
DISU vs. IL70.01277049715496710.9595804849342240.993496797244113
DISU vs. SAHA-0.00638189195049730.982671695246330.99736313011364
DMSO vs. AZA-0.08497427097702830.6124674810600651
DMSO vs. CD30.6289193772587690.05025285491736510.0967117091632735
DMSO vs. DISU-0.04205759864953380.863430690174680.984656112442056
DMSO vs. IL70.06962472613270820.6989279415576490.937788846060647
DMSO vs. SAHA0.02565193429242780.9135206064260380.979403400357616
HIV vs. Mock in Activation0.4442777085590490.4782406158091290.999983755607037
HIV vs. Mock in Latency0.1048671848627380.5256495320011570.999834320637052
IL7 vs. CD30.7082333290487530.02817979105883820.0690320153794682
SAHA vs. CD30.6459099501075070.07020878158602440.131189874581697
SAHA vs. IL7-0.03324313915790290.8919009688726380.957546202014116
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) FALSE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -0.26795 0.0450405
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
1.072 1.148 1.159 1.325 1.077
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

Drugbank ID Drug Name Drug Status Pharmacological Action Drug Action
DB00201 Caffeine approved unknown unknown

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Pr55(Gag) associates with 24904548
Pr55(Gag) interacts with 20427533
21762810
2490454821762810
Tat interacts with 10843712

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04020 Calcium signaling pathway - Homo sapiens (human)
hsa04022 cGMP-PKG signaling pathway - Homo sapiens (human)
hsa04070 Phosphatidylinositol signaling system - Homo sapiens (human)
hsa04114 Oocyte meiosis - Homo sapiens (human)
hsa04210 Apoptosis - Homo sapiens (human)
hsa04270 Vascular smooth muscle contraction - Homo sapiens (human)
hsa04540 Gap junction - Homo sapiens (human)
hsa04611 Platelet activation - Homo sapiens (human)
hsa04621 NOD-like receptor signaling pathway - Homo sapiens (human)
hsa04720 Long-term potentiation - Homo sapiens (human)
hsa04723 Retrograde endocannabinoid signaling - Homo sapiens (human)
hsa04724 Glutamatergic synapse - Homo sapiens (human)
hsa04725 Cholinergic synapse - Homo sapiens (human)
hsa04726 Serotonergic synapse - Homo sapiens (human)
hsa04728 Dopaminergic synapse - Homo sapiens (human)
hsa04730 Long-term depression - Homo sapiens (human)
hsa04750 Inflammatory mediator regulation of TRP channels - Homo sapiens (human)
hsa04912 GnRH signaling pathway - Homo sapiens (human)
hsa04915 Estrogen signaling pathway - Homo sapiens (human)
hsa04918 Thyroid hormone synthesis - Homo sapiens (human)
hsa04921 Oxytocin signaling pathway - Homo sapiens (human)
hsa04922 Glucagon signaling pathway - Homo sapiens (human)
hsa04924 Renin secretion - Homo sapiens (human)
hsa04925 Aldosterone synthesis and secretion - Homo sapiens (human)
hsa04970 Salivary secretion - Homo sapiens (human)
hsa04971 Gastric acid secretion - Homo sapiens (human)
hsa04972 Pancreatic secretion - Homo sapiens (human)
hsa05010 Alzheimer's disease - Homo sapiens (human)
hsa05205 Proteoglycans in cancer - Homo sapiens (human)
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