Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0001472
UniProt IDP27987
Primary gene name(s)ITPKB
Synonym gene name(s)unknown
Protein nameInositol-trisphosphate 3-kinase B
Protein functionunknown
Subcellular locationunknown
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P27987
Gene Ontology
(Biological Process)
Complete annatation
cell surface receptor signaling pathway [GO:0007166];
cellular response to calcium ion [GO:0071277];
common myeloid progenitor cell proliferation [GO:0035726];
inositol phosphate metabolic process [GO:0043647];
inositol trisphosphate metabolic process [GO:0032957];
MAPK cascade [GO:0000165];
myeloid cell homeostasis [GO:0002262];
negative regulation of myeloid cell differentiation [GO:0045638];
negative regulation of neutrophil apoptotic process [GO:0033030];
positive regulation of alpha-beta T cell differentiation [GO:0046638];
positive regulation of Ras protein signal transduction [GO:0046579];
positive thymic T cell selection [GO:0045059];
regulation of protein phosphorylation [GO:0001932];
signal transduction [GO:0007165]
Gene Ontology
(Molecular Function)
Complete annatation
ATP binding [GO:0005524];
inositol-1,4,5-trisphosphate 3-kinase activity [GO:0008440]
Gene Ontology
(Cellular Component)
Complete annatation
cytosol [GO:0005829];
membrane [GO:0016020];
nucleus [GO:0005634]
Protein-protein interaction109912
Phylogenetic treeP27987
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
      unknown
Brass et al., Science, 2008
      unknown
Smith et al., J. Immunol, 2010
      unknown
Interferon-stimulated
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model


DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-1.696249789837094.72535791051776e-073.93991664484656e-06
AZA vs. DISU0.2930730784846580.2529170715802340.834111717141601
AZA vs. IL7-0.4414371879781450.02214740327628230.475006832565919
AZA vs. SAHA0.08578389923740470.7252136887420380.923407119489742
DISU vs. CD31.97714474474491.65000939245097e-071.91324935244661e-06
DISU vs. IL7-0.7432228139127560.003575156676414840.0611059942142332
DISU vs. SAHA-0.2063344883541180.4819156776830350.812592434365744
DMSO vs. AZA0.03042080513720740.8560152081564661
DMSO vs. CD31.710926119691971.95491475230014e-071.61551238307195e-06
DMSO vs. DISU-0.2657798259328240.2829487888544760.798111145486858
DMSO vs. IL7-0.4639028271313080.01013037478941830.210759077604118
DMSO vs. SAHA0.04948452370870680.833696316010860.954996474104914
HIV vs. Mock in Activation-0.2842076499257180.6488565246599520.999983755607037
HIV vs. Mock in Latency-0.2117202354898860.1997429632444410.999834320637052
IL7 vs. CD31.263287298785190.0001086542643037310.0006258462928849
SAHA vs. CD31.756541515460161.35414757473917e-061.06341865301299e-05
SAHA vs. IL70.5226179552249070.03231520925855920.137410286139216
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) TRUE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -0.855378 0.000305467
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
203723_at 1.51 No downregulated in CD8+ cells

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa00562 Inositol phosphate metabolism - Homo sapiens (human)
hsa01100 Metabolic pathways - Homo sapiens (human)
hsa04020 Calcium signaling pathway - Homo sapiens (human)
hsa04070 Phosphatidylinositol signaling system - Homo sapiens (human)
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