Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0001469
UniProt IDP26010
Primary gene name(s)ITGB7
Synonym gene name(s)unknown
Protein nameIntegrin beta-7
Protein functionIntegrin alpha-4/beta-7, Peyer patches-specific homing receptor LPAM-1 is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue, GALT. Integrin alpha-4/beta-7 interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular endothelium of the gastrointestinal tract. Interacts also with VCAM1 and fibronectin, an extracellular matrix component. It recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin. Interactions involves the tripeptide L-D-T in MADCAM1, and L-D-V in fibronectin. Binds to HIV-1 gp120, thereby allowing the virus to enter GALT, which is thought to be the major trigger of AIDS disease. Interaction would involve a tripeptide L-D-I in HIV-1 gp120. Integrin alpha-E/beta-7, HML-1 is a receptor for E-cadherin.
Subcellular locationMembrane;
Single-pass type I membrane protein.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P26010
Gene Ontology
(Biological Process)
Complete annatation
cell adhesion [GO:0007155];
cell-matrix adhesion [GO:0007160];
cell-matrix adhesion involved in ameboidal cell migration [GO:0003366];
extracellular matrix organization [GO:0030198];
heterotypic cell-cell adhesion [GO:0034113];
integrin-mediated signaling pathway [GO:0007229];
leukocyte tethering or rolling [GO:0050901];
receptor clustering [GO:0043113];
regulation of immune response [GO:0050776];
substrate adhesion-dependent cell spreading [GO:0034446];
T cell migration [GO:0072678]
Gene Ontology
(Molecular Function)
Complete annatation
cell adhesion molecule binding [GO:0050839];
metal ion binding [GO:0046872];
virus receptor activity [GO:0001618]
Gene Ontology
(Cellular Component)
Complete annatation
cell surface [GO:0009986];
extracellular exosome [GO:0070062];
integrin alpha4-beta7 complex [GO:0034669];
integrin complex [GO:0008305];
membrane [GO:0016020];
plasma membrane [GO:0005886];
receptor complex [GO:0043235]
Protein-protein interaction109901
Phylogenetic treeP26010
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-1.366475256045974.3100214052294e-050.000229786496708941
AZA vs. DISU-0.3295947608771090.2129122633912960.801649999689472
AZA vs. IL7-0.1310966038500240.4940351950434850.999311006273513
AZA vs. SAHA-0.3283847007014720.17775227544360.538255885905347
DISU vs. CD31.024947056336410.005634157284651780.0179100141098357
DISU vs. IL70.1887864652996260.4555371849216510.799257805248357
DISU vs. SAHA0.003894768595886070.9893771135173020.999274089415579
DMSO vs. AZA0.06215488228027580.7092081945068681
DMSO vs. CD31.416535514778711.41553306309827e-057.88355105196876e-05
DMSO vs. DISU0.3897983169390930.110915084448820.586319898851999
DMSO vs. IL7-0.1858866672387350.299559546814650.785503595100166
DMSO vs. SAHA-0.3953826177970920.09313745073306080.358629156872243
HIV vs. Mock in Activation0.2215777411572340.7214970018686930.999983755607037
HIV vs. Mock in Latency0.1814584087178880.2695892651462540.999834320637052
IL7 vs. CD31.240809874567860.0001391275284079450.000779869555854577
SAHA vs. CD31.015575185285120.004409109503328620.0128322287012674
SAHA vs. IL7-0.1994556342625650.4115726718422450.65697736006997
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change 3.040503985
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) TRUE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.250941 0.0647953
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

Drugbank ID Drug Name Drug Status Pharmacological Action Drug Action
DB05122 R1295 investigational unknown unknown
DB05802 MLN-02 investigational unknown unknown
DB09033 Vedolizumab approved yes antibody

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
2BRQ X-ray 2.1Å C/D=768-798.
3V4P X-ray 3.1Å B/D=20-512.
3V4V X-ray 3.1Å B/D=20-512.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Envelope transmembrane glycoprotein gp41 complexes with 21926353
Envelope surface glycoprotein gp160; precursor binds 25008916
Envelope surface glycoprotein gp120 complexes with 18264102
Envelope surface glycoprotein gp120 interacts with 21383973
Envelope surface glycoprotein gp120 binds 18264102
HIV-1 virus replication enhanced by expression of human gene 19460752

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
hsa04510 Focal adhesion - Homo sapiens (human)
hsa04512 ECM-receptor interaction - Homo sapiens (human)
hsa04514 Cell adhesion molecules (CAMs) - Homo sapiens (human)
hsa04672 Intestinal immune network for IgA production - Homo sapiens (human)
hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human)
hsa05202 Transcriptional misregulation in cancer - Homo sapiens (human)
hsa05410 Hypertrophic cardiomyopathy (HCM) - Homo sapiens (human)
hsa05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) - Homo sapiens (human)
hsa05414 Dilated cardiomyopathy - Homo sapiens (human)