Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0001468
UniProt IDP06756
Primary gene name(s)ITGAV
Synonym gene name(s)MSK8, VNRA
Protein nameIntegrin alpha-V
Protein functionThe alpha-V, ITGAV integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. ITGAV:ITGB3 binds to fractalkine, CX3CL1 and may act as its coreceptor in CX3CR1-dependent fractalkine signaling, PubMed:23125415. ITGAV:ITGB3 binds to NRG1, via EGF domain and this binding is essential for NRG1-ERBB signaling, PubMed:20682778. ITGAV:ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling, PubMed:18441324. ITGAV:ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling, PubMed:19578119. ITGAV:ITGB3 binds to PLA2G2A via a site, site 2 which is distinct from the classical ligand-binding site, site 1 and this induces integrin conformational changes and enhanced ligand binding to site 1, PubMed:18635536, PubMed:25398877. ITGAV:ITGB3 and ITGAV:ITGB6 act as a receptor for fibrillin-1, FBN1 and mediate R-G-D-dependent cell adhesion to FBN1, PubMed:12807887, PubMed:17158881. {ECO:0000269|PubMed:12807887, ECO:0000269|PubMed:17158881, ECO:0000269|PubMed:18441324, ECO:0000269|PubMed:18635536, ECO:0000269|PubMed:19578119, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:23125415, ECO:0000269|PubMed:25398877}.; FUNCTION:, Microbial infection Integrin ITGAV:ITGB5 acts as a receptor for adenovirus type C, PubMed:20615244. Integrin ITGAV:ITGB5 and ITGAV:ITGB3 act as receptors for coxsackievirus A9 and B1, PubMed:9426447, PubMed:15194773, PubMed:7519807. Integrin ITGAV:ITGB3 acts as a receptor for herpes virus 8/HHV-8, PubMed:18045938. Integrin ITGAV:ITGB6 acts as a receptor for herpes simplex 1/HHV-1, PubMed:24367260. Integrin ITGAV:ITGB3 acts as a receptor for Human parechovirus 1, PubMed:11160695. Integrin ITGAV:ITGB3 acts as a receptor for West nile virus, PubMed:23658209. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions, PubMed:10397733. {ECO:0000269|PubMed:10397733, ECO:0000269|PubMed:11160695, ECO:0000269|PubMed:15194773, ECO:0000269|PubMed:18045938, ECO:0000269|PubMed:20615244, ECO:0000269|PubMed:23658209, ECO:0000269|PubMed:24367260, ECO:0000269|PubMed:7519807, ECO:0000269|PubMed:9426447}.
Subcellular locationMembrane;
Single-pass type I membrane protein. Cell junction, focal adhesion {ECO:0000269|PubMed:17158881}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P06756
Gene Ontology
(Biological Process)
Complete annatation
angiogenesis [GO:0001525];
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [GO:0002479];
apolipoprotein A-I-mediated signaling pathway [GO:0038027];
apoptotic cell clearance [GO:0043277];
calcium ion transmembrane transport [GO:0070588];
cell adhesion [GO:0007155];
cell adhesion mediated by integrin [GO:0033627];
cell growth [GO:0016049];
cell-matrix adhesion [GO:0007160];
cell migration [GO:0016477];
cell-substrate adhesion [GO:0031589];
endodermal cell differentiation [GO:0035987];
entry of symbiont into host cell by promotion of host phagocytosis [GO:0052066];
ERK1 and ERK2 cascade [GO:0070371];
extracellular matrix organization [GO:0030198];
extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192];
heterotypic cell-cell adhesion [GO:0034113];
integrin-mediated signaling pathway [GO:0007229];
leukocyte migration [GO:0050900];
negative chemotaxis [GO:0050919];
negative regulation of entry of bacterium into host cell [GO:2000536];
negative regulation of extrinsic apoptotic signaling pathway [GO:2001237];
negative regulation of lipid storage [GO:0010888];
negative regulation of lipid transport [GO:0032369];
negative regulation of lipoprotein metabolic process [GO:0050748];
negative regulation of low-density lipoprotein particle receptor biosynthetic process [GO:0045715];
negative regulation of macrophage derived foam cell differentiation [GO:0010745];
positive regulation of cell adhesion [GO:0045785];
positive regulation of cell migration [GO:0030335];
positive regulation of cell proliferation [GO:0008284];
positive regulation of osteoblast proliferation [GO:0033690];
regulation of apoptotic cell clearance [GO:2000425];
regulation of phagocytosis [GO:0050764];
substrate adhesion-dependent cell spreading [GO:0034446];
vascular endothelial growth factor receptor signaling pathway [GO:0048010];
viral entry into host cell [GO:0046718]
Gene Ontology
(Molecular Function)
Complete annatation
coreceptor activity [GO:0015026];
extracellular matrix binding [GO:0050840];
extracellular matrix protein binding [GO:1990430];
fibronectin binding [GO:0001968];
metal ion binding [GO:0046872];
protease binding [GO:0002020];
transforming growth factor beta binding [GO:0050431];
virus receptor activity [GO:0001618];
voltage-gated calcium channel activity [GO:0005245]
Gene Ontology
(Cellular Component)
Complete annatation
alphav-beta3 integrin-IGF-1-IGF1R complex [GO:0035867];
cell surface [GO:0009986];
external side of plasma membrane [GO:0009897];
extracellular exosome [GO:0070062];
filopodium membrane [GO:0031527];
focal adhesion [GO:0005925];
integral component of plasma membrane [GO:0005887];
integrin alphav-beta3 complex [GO:0034683];
integrin alphav-beta5 complex [GO:0034684];
integrin alphav-beta8 complex [GO:0034686];
integrin complex [GO:0008305];
lamellipodium membrane [GO:0031258];
membrane [GO:0016020];
microvillus membrane [GO:0031528];
phagocytic vesicle [GO:0045335];
plasma membrane [GO:0005886];
ruffle membrane [GO:0032587]
Protein-protein interaction109891
Phylogenetic treeP06756
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
      unknown
Brass et al., Science, 2008
      unknown
Smith et al., J. Immunol, 2010
      unknown
Interferon-stimulated
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model


DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD30.1169853794042160.7212133399061420.803053151526697
AZA vs. DISU0.06417059060261230.8553047591302530.989951370113767
AZA vs. IL7-0.1798433143681720.3532046055907880.999311006273513
AZA vs. SAHA0.4088720098022690.09591035590193990.391272721208617
DISU vs. CD3-0.06537907556639520.859004387702040.904802149413165
DISU vs. IL7-0.2523475430225350.4559116559220780.79972867268156
DISU vs. SAHA0.3447220688260640.3208882036411360.703482610458357
DMSO vs. AZA-0.1319402056421120.4356288060769881
DMSO vs. CD3-0.2591674233536570.418346273698430.532631248077238
DMSO vs. DISU-0.1976301969504340.5414973967543630.921635859189505
DMSO vs. IL7-0.04079506009545370.8219535770251520.962956477091318
DMSO vs. SAHA0.5323085689358280.02492171434770190.163658020450638
HIV vs. Mock in Activation0.1387567094146470.8238214856134780.999983755607037
HIV vs. Mock in Latency-0.1729168620942080.4410863144914610.999834320637052
IL7 vs. CD3-0.2875865630513980.3716041706898540.508782783614149
SAHA vs. CD30.265522265946640.4530465212576810.565604430068201
SAHA vs. IL70.5834396741505150.01747230164571780.0919293106483594
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) TRUE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -0.17474 0.292806
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

Drugbank ID Drug Name Drug Status Pharmacological Action Drug Action
DB00098 Anti-thymocyte Globulin (Rabbit) approved yes unknown

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
1JV2 X-ray 3.1Å A=31-987.
1L5G X-ray 3.2Å A=31-987.
1M1X X-ray 3.3Å A=31-987.
1U8C X-ray 3.1Å A=31-987.
3IJE X-ray 2.9Å A=31-997.
4G1E X-ray 3.0Å A=31-989.
4G1M X-ray 2.9Å A=31-989.
4MMX X-ray 3.3Å A=31-989.
4MMY X-ray 3.1Å A=31-989.
4MMZ X-ray 3.1Å A=31-989.
4O02 X-ray 3.6Å A=31-992.
4UM8 X-ray 2.8Å A/C=31-625.
4UM9 X-ray 2.5Å A/C=31-625.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04145 Phagosome - Homo sapiens (human)
hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
hsa04510 Focal adhesion - Homo sapiens (human)
hsa04512 ECM-receptor interaction - Homo sapiens (human)
hsa04514 Cell adhesion molecules (CAMs) - Homo sapiens (human)
hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human)
hsa04919 Thyroid hormone signaling pathway - Homo sapiens (human)
hsa05200 Pathways in cancer - Homo sapiens (human)
hsa05205 Proteoglycans in cancer - Homo sapiens (human)
hsa05222 Small cell lung cancer - Homo sapiens (human)
hsa05410 Hypertrophic cardiomyopathy (HCM) - Homo sapiens (human)
hsa05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) - Homo sapiens (human)
hsa05414 Dilated cardiomyopathy - Homo sapiens (human)
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