Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0001453
UniProt IDQ86VI3
Primary gene name(s)IQGAP3
Synonym gene name(s)unknown
Protein nameRas GTPase-activating-like protein IQGAP3
Protein functionunknown
Subcellular locationunknown
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q86VI3
Gene Ontology
(Biological Process)
Complete annatation
activation of MAPK activity [GO:0000187];
cellular response to organic substance [GO:0071310];
ERK1 and ERK2 cascade [GO:0070371];
G1/S transition of mitotic cell cycle [GO:0000082];
negative regulation of gene expression [GO:0010629];
positive regulation of gene expression [GO:0010628];
positive regulation of mammary gland epithelial cell proliferation [GO:0033601];
Ras protein signal transduction [GO:0007265];
regulation of cell size [GO:0008361];
regulation of GTPase activity [GO:0043087]
Gene Ontology
(Molecular Function)
Complete annatation
calmodulin binding [GO:0005516];
GTPase activator activity [GO:0005096];
myosin VI light chain binding [GO:0070856]
Gene Ontology
(Cellular Component)
Complete annatation
cell-cell junction [GO:0005911];
cytosol [GO:0005829];
lateral plasma membrane [GO:0016328]
Protein-protein interaction126102
Phylogenetic treeQ86VI3
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
      unknown
Brass et al., Science, 2008
      unknown
Smith et al., J. Immunol, 2010
      unknown
Interferon-stimulated
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model


DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-0.6328049693796140.5793369473453560.686891635493172
AZA vs. DISU-0.6472098710236040.2362123314067970.82103799898299
AZA vs. IL7-0.1565701979910180.7869188314985630.999311006273513
AZA vs. SAHA-0.7090981200970370.2855723482442910.657108468544412
DISU vs. CD3-0.0235842497255720.9835173427322860.989688946885613
DISU vs. IL70.4805270807619210.4107331822741780.76991882918678
DISU vs. SAHA-0.06264466237834750.9249459227798840.982806795139101
DMSO vs. AZA0.02110980825857220.9739064545957261
DMSO vs. CD30.6370422172757190.5790546119790630.678104458984883
DMSO vs. DISU0.6641490811298560.3046589103053870.811498856723186
DMSO vs. IL7-0.1689844120481460.8012326699287030.959302875003986
DMSO vs. SAHA-0.7369613058990820.3215055442747180.674754220549266
HIV vs. Mock in Activation0.4293978942537220.8359044708343730.999983755607037
HIV vs. Mock in Latency0.1898804641522090.7048630369001180.999834320637052
IL7 vs. CD30.4846861174470210.6692491927468580.773661284710421
SAHA vs. CD3-0.1040208654792740.9298240753819090.950705530633378
SAHA vs. IL7-0.555796510037680.4221830128915510.664940140578935
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander 0.864 1.80E-10 1.35E-08
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) TRUE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.66763 0.000305467
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
0.952 1.072 1.315 1.502 1.255
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
3ISU X-ray 1.8Å A=1529-1631.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human)
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