Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0001445
UniProt IDQ9NVH2
Primary gene name(s)INTS7
Synonym gene name(s)C1orf73
Protein nameIntegrator complex subunit 7
Protein functionComponent of the Integrator complex, a complex involved in the small nuclear RNAs, snRNA U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain, CTD of RNA polymerase II largest subunit, POLR2A and is recruited to the U1 and U2 snRNAs genes. Plays a role in DNA damage response, DDR signaling during the S phase. {ECO:0000269|PubMed:21659603}.
Subcellular locationNucleus {ECO:0000269|PubMed:21659603}. Chromosome {ECO:0000269|PubMed:21659603}. Note=Localizes to sites of DNA damage in a H2AX-independent manner.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q9NVH2
Gene Ontology
(Biological Process)
Complete annatation
cellular response to ionizing radiation [GO:0071479];
DNA damage checkpoint [GO:0000077];
snRNA 3'-end processing [GO:0034472];
snRNA processing [GO:0016180];
snRNA transcription from RNA polymerase II promoter [GO:0042795]
Gene Ontology
(Molecular Function)
Complete annatation
Gene Ontology
(Cellular Component)
Complete annatation
chromosome [GO:0005694];
integrator complex [GO:0032039];
nucleoplasm [GO:0005654]
Protein-protein interaction117404
Phylogenetic treeQ9NVH2
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD31.09225508357880.001235760397808480.00437420871671429
AZA vs. DISU0.5097583263964610.04526117381397110.483534326060808
AZA vs. IL70.4146768874353370.03275636962435410.563712690119688
AZA vs. SAHA-0.5472026664077630.02805734337952190.191547279937914
DISU vs. CD3-0.5950826846166620.105826170179480.195015120939545
DISU vs. IL7-0.1043455613168180.6793018266078440.913399072308184
DISU vs. SAHA-1.055363427708210.0003775701016112130.0101806907433416
DMSO vs. AZA0.002591129793004560.9878085343267431
DMSO vs. CD3-1.099826124510680.0008341361253548780.00291974080470151
DMSO vs. DISU-0.5086299595199150.03819737761662740.394270192248339
DMSO vs. IL70.4190214134605790.0209981631883350.297786745121496
DMSO vs. SAHA-0.5562631241057270.02054748023567630.144234315152249
HIV vs. Mock in Activation0.02115851165950880.9728729951551150.999983755607037
HIV vs. Mock in Latency0.1283610999272790.4420742465979160.999834320637052
IL7 vs. CD3-0.670368262249070.03968024735328480.0910905221376884
SAHA vs. CD3-1.664022262638034.61474787505356e-063.17843923569731e-05
SAHA vs. IL7-0.9649061009999569.8967656490756e-050.0019424979869032
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) FALSE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.233551 0.456679
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
0.93 0.915 0.801 0.817 1.003
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
218783_at 2.65 No upregulated in CD8+ cells

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
HIV-1 virus replication enhanced by expression of human gene 18187620

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
not found