Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0001438
UniProt IDQ9NRR6
Primary gene name(s)INPP5E
Synonym gene name(s)unknown
Protein name72 kDa inositol polyphosphate 5-phosphatase
Protein functionConverts phosphatidylinositol 3,4,5-trisphosphate, PtdIns 3,4,5-P3 to PtdIns-P2, and phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4-phosphate. Specific for lipid substrates, inactive towards water soluble inositol phosphates. {ECO:0000269|PubMed:10764818}.
Subcellular locationCytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:19668215, ECO:0000269|PubMed:19668216, ECO:0000269|PubMed:24166846}. Golgi apparatus, Golgi stack membrane {ECO:0000250|UniProtKB:Q9JII1};
Peripheral membrane protein {ECO:0000250|UniProtKB:Q9JII1};
Cytoplasmic side {ECO:0000250|UniProtKB:Q9JII1}. Cell membrane {ECO:0000250|UniProtKB:Q9WVR1};
Peripheral membrane protein {ECO:0000250|UniProtKB:Q9WVR1};
Cytoplasmic side {ECO:0000250|UniProtKB:Q9WVR1}. Cell projection, ruffle {ECO:0000250|UniProtKB:Q9WVR1}. Cytoplasm {ECO:0000250|UniProtKB:Q9WVR1}. Note=Peripheral membrane protein associated with Golgi stacks. {ECO:0000250|UniProtKB:Q9JII1}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q9NRR6
Gene Ontology
(Biological Process)
Complete annatation
inositol phosphate dephosphorylation [GO:0046855];
phosphatidylinositol biosynthetic process [GO:0006661];
phosphatidylinositol dephosphorylation [GO:0046856]
Gene Ontology
(Molecular Function)
Complete annatation
inositol-polyphosphate 5-phosphatase activity [GO:0004445];
phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity [GO:0004439]
Gene Ontology
(Cellular Component)
Complete annatation
axoneme [GO:0005930];
cytoskeleton [GO:0005856];
cytosol [GO:0005829];
Golgi cisterna membrane [GO:0032580];
plasma membrane [GO:0005886];
primary cilium [GO:0072372];
ruffle [GO:0001726]
Protein-protein interactionunknown
Phylogenetic treeQ9NRR6
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      Yes - >4 <5 SD (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD30.06365519657281160.8468316285320780.897633188356107
AZA vs. DISU0.4647325229034650.06879521675744120.5732554435609
AZA vs. IL7-0.2247349902432950.2500433054884780.999311006273513
AZA vs. SAHA0.3958251162784460.1078321470332760.417527177411671
DISU vs. CD30.3879356654045960.2906962260352310.421503935288098
DISU vs. IL7-0.6990998818966530.006104835408275330.0849772795750237
DISU vs. SAHA-0.06605066788248020.8218541481621160.954457236048875
DMSO vs. AZA0.07757738606198930.6496268028767971
DMSO vs. CD30.001491791000825520.9962970007993710.997289987843358
DMSO vs. DISU-0.3890359303922290.1141722043648270.590652778477021
DMSO vs. IL7-0.2948000943499010.106844532418980.58941865007983
DMSO vs. SAHA0.3133720442157460.1870506613590730.521849711198099
HIV vs. Mock in Activation0.2550179210827150.6832479192831370.999983755607037
HIV vs. Mock in Latency-0.1063080754402320.5254651225983740.999834320637052
IL7 vs. CD3-0.2838730160202390.3807354571713860.517570846495699
SAHA vs. CD30.3091173124323590.3834939037141590.500108439682622
SAHA vs. IL70.6183246698455750.01206350469014050.0712559834244428
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
0.4824 0.02148

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) TRUE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.299187 0.0506067
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
2XSW X-ray 1.9Å A/B=275-623.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Pr55(Gag) inhibited by 15465916
HIV-1 virus replication inhibited by expression of human gene 22082156

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa00562 Inositol phosphate metabolism - Homo sapiens (human)
hsa01100 Metabolic pathways - Homo sapiens (human)
hsa04070 Phosphatidylinositol signaling system - Homo sapiens (human)