Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0001434
UniProt IDQ8WYH8
Primary gene name(s)ING5
Synonym gene name(s)unknown
Protein nameInhibitor of growth protein 5
Protein functionComponent of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Through chromatin acetylation it may regulate DNA replication and may function as a transcriptional coactivator. {ECO:0000269|PubMed:12750254, ECO:0000269|PubMed:16387653}.
Subcellular locationNucleus {ECO:0000269|PubMed:18794358}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q8WYH8
Gene Ontology
(Biological Process)
Complete annatation
DNA replication [GO:0006260];
histone H3 acetylation [GO:0043966];
negative regulation of cell proliferation [GO:0008285];
negative regulation of growth [GO:0045926];
positive regulation of apoptotic process [GO:0043065];
positive regulation of apoptotic signaling pathway [GO:2001235];
positive regulation of transcription, DNA-templated [GO:0045893];
protein acetylation [GO:0006473];
regulation of signal transduction by p53 class mediator [GO:1901796];
transcription, DNA-templated [GO:0006351]
Gene Ontology
(Molecular Function)
Complete annatation
chromatin binding [GO:0003682];
methylated histone binding [GO:0035064];
zinc ion binding [GO:0008270]
Gene Ontology
(Cellular Component)
Complete annatation
MOZ/MORF histone acetyltransferase complex [GO:0070776];
nucleoplasm [GO:0005654];
nucleus [GO:0005634]
Protein-protein interaction124016
Phylogenetic treeQ8WYH8
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD30.3908775238359970.235184240629690.345756620637016
AZA vs. DISU0.2927660672649890.2493174965580240.831029075563411
AZA vs. IL7-0.03042933544376150.8754619717460020.999311006273513
AZA vs. SAHA-1.193185945434730.01587918966046560.13216262636524
DISU vs. CD3-0.110653463306950.761066889331420.834340652927425
DISU vs. IL7-0.3323845443357680.1891669463185030.563096804381579
DISU vs. SAHA-1.484113504374150.002836715947664770.0435357902721545
DMSO vs. AZA0.05493839725764360.7462350360699031
DMSO vs. CD3-0.3466068113259910.281575552234850.390170685652871
DMSO vs. DISU-0.2394534063126690.3283757338524670.829252035457872
DMSO vs. IL7-0.07796328372479560.6678564608143140.931620201164749
DMSO vs. SAHA-1.254740390970220.01097328080565090.095499502451414
HIV vs. Mock in Activation-0.007779331066445240.9900303886352040.999983755607037
HIV vs. Mock in Latency0.02184573836249410.8957512540920860.999834320637052
IL7 vs. CD3-0.414632747264810.1990062797117430.321399512921366
SAHA vs. CD3-1.607958719936750.002446565901614740.00769241563474528
SAHA vs. IL7-1.166362321954690.01934034310795540.0982380132162551
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
-0.3081 0.04231

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change -1.061990942
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
-1.2 0.116001432 -1.4 0.001419496 -1.7 9.63E-05
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) FALSE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -0.146442 0.480222
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
1.18 1.049 0.913 0.81 0.964
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
3C6W X-ray 1.7Å A/C=184-236.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
not found