Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0001424
UniProt IDP16871
Primary gene name(s)IL7R
Synonym gene name(s)unknown
Protein nameInterleukin-7 receptor subunit alpha
Protein functionReceptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin, TSLP.
Subcellular locationIsoform 1: Cell membrane;
Single-pass type I membrane protein.;
SUBCELLULAR LOCATION: Isoform 3: Cell membrane;
Single-pass type I membrane protein.;
SUBCELLULAR LOCATION: Isoform 4: Secreted.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P16871
Gene Ontology
(Biological Process)
Complete annatation
B cell proliferation [GO:0042100];
cell growth [GO:0016049];
cell morphogenesis [GO:0000902];
cell surface receptor signaling pathway [GO:0007166];
homeostasis of number of cells [GO:0048872];
immune response [GO:0006955];
immunoglobulin production [GO:0002377];
lymph node development [GO:0048535];
negative regulation of T cell mediated cytotoxicity [GO:0001915];
positive regulation of gene expression [GO:0010628];
positive regulation of T cell differentiation in thymus [GO:0033089];
regulation of cell size [GO:0008361];
regulation of DNA recombination [GO:0000018];
signal transduction [GO:0007165];
T cell differentiation [GO:0030217]
Gene Ontology
(Molecular Function)
Complete annatation
antigen binding [GO:0003823];
interleukin-7 receptor activity [GO:0004917]
Gene Ontology
(Cellular Component)
Complete annatation
external side of plasma membrane [GO:0009897];
extracellular region [GO:0005576];
integral component of membrane [GO:0016021];
plasma membrane [GO:0005886]
Protein-protein interaction109789
Phylogenetic treeP16871
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-3.231968958052541.17011955680368e-112.36091592505289e-10
AZA vs. DISU0.1455688129162820.5938291852444440.955158276076142
AZA vs. IL7-0.808064265200780.003930052447452260.191089292065961
AZA vs. SAHA-0.1520979749526330.585844939371050.862724238403347
DISU vs. CD33.363691202947991.75415237890775e-136.99526268773952e-12
DISU vs. IL7-0.9618494457080610.00014906244989410.00713370295921762
DISU vs. SAHA-0.2981027494702710.3065091524171480.690596417413491
DMSO vs. AZA-0.06355374408651670.8154944464489471
DMSO vs. CD33.150355297627431.29007915461443e-122.76458641027972e-11
DMSO vs. DISU-0.2129355430912110.3815740761445540.857293254744302
DMSO vs. IL7-0.7364147624733570.0023317200275490.0950018362575707
DMSO vs. SAHA-0.0955037804858960.6926375412903920.906088335056973
HIV vs. Mock in Activation0.2401511921640710.7818352230458040.999983755607037
HIV vs. Mock in Latency-0.1032617024422220.6941653167541470.999834320637052
IL7 vs. CD32.434188597228555.01075537728823e-086.57329119250353e-07
SAHA vs. CD33.05245497598952.02390326720092e-114.92322263601791e-10
SAHA vs. IL70.6497351713091780.008989004633689120.057857295915929
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
-1.3 0.164008025 -1.9 0.002674929 -2.7 0.001532554
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) FALSE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -0.73881 0.000305467
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
205798_at 1.54 No downregulated in CD8+ cells

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
3DI2 X-ray 2.7Å B/D=21-239.
3DI3 X-ray 2.9Å B=21-239.
3UP1 X-ray 2.1Å A/B=21-239.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Tat inhibits 16967044
Tat upregulates 16614257
Tat degrades 20660706
Vif upregulates 23333304
Tat downregulates 16967044

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human)
hsa04068 FoxO signaling pathway - Homo sapiens (human)
hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
hsa04630 Jak-STAT signaling pathway - Homo sapiens (human)
hsa04640 Hematopoietic cell lineage - Homo sapiens (human)
hsa05340 Primary immunodeficiency - Homo sapiens (human)