Protein Information (annotations from UniProt)
| Database ID | HIV0001419 |
| UniProt ID | Q9NPF7 |
| Primary gene name(s) | IL23A |
| Synonym gene name(s) | SGRF |
| Protein name | Interleukin-23 subunit alpha |
| Protein function | Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis. {ECO:0000269|PubMed:11114383, ECO:0000269|PubMed:12023369, ECO:0000269|PubMed:16424222}. |
| Subcellular location | Secreted {ECO:0000269|PubMed:11114383}. Note=Secreted upon association with IL12B. |
| ECO code | Click here for more information. |
| Amino acid sequence FASTA format: Q9NPF7 |
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| Gene Ontology (Biological Process) Complete annatation | defense response to Gram-negative bacterium [GO:0050829]; defense response to virus [GO:0051607]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; negative regulation of interleukin-10 production [GO:0032693]; positive regulation of activated T cell proliferation [GO:0042104]; positive regulation of activation of JAK2 kinase activity [GO:0010535]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of granulocyte macrophage colony-stimulating factor production [GO:0032725]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interferon-gamma production [GO:0032729]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-17 production [GO:0032740]; positive regulation of memory T cell differentiation [GO:0043382]; positive regulation of natural killer cell activation [GO:0032816]; positive regulation of natural killer cell proliferation [GO:0032819]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of NF-kappaB import into nucleus [GO:0042346]; positive regulation of NK T cell activation [GO:0051135]; positive regulation of NK T cell proliferation [GO:0051142]; positive regulation of osteoclast differentiation [GO:0045672]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of T-helper 17 cell lineage commitment [GO:2000330]; positive regulation of T-helper 17 type immune response [GO:2000318]; positive regulation of T-helper 1 type immune response [GO:0002827]; positive regulation of tissue remodeling [GO:0034105]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of tyrosine phosphorylation of Stat3 protein [GO:0042517]; positive regulation of tyrosine phosphorylation of Stat4 protein [GO:0042520]; positive regulation of tyrosine phosphorylation of Stat5 protein [GO:0042523]; regulation of tyrosine phosphorylation of Stat1 protein [GO:0042510]; T cell proliferation [GO:0042098]; tissue remodeling [GO:0048771] |
| Gene Ontology (Molecular Function) Complete annatation | unknown |
| Gene Ontology (Cellular Component) Complete annatation | extracellular region [GO:0005576]; interleukin-23 complex [GO:0070743] |
| Protein-protein interaction | 119611 |
| Phylogenetic tree | Q9NPF7 |
| HIV replication factor status |
Zhou et al., Cell. Host. Microbe., 2008 unknown Brass et al., Science, 2008 unknown Smith et al., J. Immunol, 2010 unknown |
| Interferon-stimulated gene status |
Lu et al., J. Virol., 2011 Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown; Schoggins JW and Rice CM, Curr. Opin. Virol., 2011 Targeted viruses: unknown Viral life cycle: unknown Mechanism related to antiviral activity: unknown |
| Anti-viral restriction factor |
Liu et al., Retrovirology, 2011 unknown (Triplicates) |
Gene Expression Profile top
Up-regulated; 
Down-regulated
For brief introduction to each study, please go to the help page.
Gene expression during HIV latency
| (1). Mohammadi et al., PLoS Pathog., 2014 Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model DMSO: Dimethyl suloxyde (negative control) - 0.0033% final SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies IL7: Interleukin-7 based stimulation DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM |
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| Experimental Condition | Log2 Fold Change | P value | Adjusted P value |
| AZA vs. CD3 | 0.977100803590441 | 0.00346490881796946 | 0.0106512554975394 |
| AZA vs. DISU | 0.242166957819681 | 0.350166679820056 | 0.887429206006287 |
| AZA vs. IL7 | -0.287583643916981 | 0.154889675843704 | 0.922020841096286 |
| AZA vs. SAHA | -1.00250348016586 | 0.0001006042966335 | 0.00380077485577287 |
| DISU vs. CD3 | -0.749274589728916 | 0.04080229923964 | 0.0916622740295578 |
| DISU vs. IL7 | -0.539249804741531 | 0.037223496499974 | 0.253162530269032 |
| DISU vs. SAHA | -1.24328306504911 | 5.01798981333845e-05 | 0.00224409864916391 |
| DMSO vs. AZA | -0.0168101225388968 | 0.924768920116214 | 1 |
| DMSO vs. CD3 | -1.01108113269165 | 0.00194590633054581 | 0.00609081214828021 |
| DMSO vs. DISU | -0.262255318386759 | 0.29390916256248 | 0.806677299793064 |
| DMSO vs. IL7 | -0.263166769527794 | 0.164908234410408 | 0.672769899107559 |
| DMSO vs. SAHA | -0.990954985629051 | 6.89839257108638e-05 | 0.00268645153588741 |
| HIV vs. Mock in Activation | 0.4506203072181 | 0.47161173428806 | 0.999983755607037 |
| HIV vs. Mock in Latency | -0.388025279338024 | 0.0240908729943471 | 0.586947535290621 |
| IL7 vs. CD3 | -1.25747605081396 | 0.00013891886367301 | 0.000778989595291398 |
| SAHA vs. CD3 | -2.00521595292364 | 9.30158313705576e-08 | 9.84374001934201e-07 |
| SAHA vs. IL7 | -0.720802115986222 | 0.00500467902036517 | 0.0384312437865433 |
| (2). Iglesias-Ussel et al., J. Virol., 2013 Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model |
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| Log2 Fold Change | P Value | ||
| unknown | unknown | ||
Gene expression during HIV infection and replication
| (1). Imbeault et al., PloS Pathog., 2012 Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells |
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| Experiment type | Log2 Fold Change | P Value | Adjusted P Value | ||
| Infected vs. Mock | unknown | unknown | unknown | ||
| Infected vs. Bystander | unknown | unknown | unknown | ||
| (2). Lefebvre et al., J. Virol., 2011 Transcriptome analysis of T-cell line (Sup T1) |
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| Log2 Fold Change | unknown | ||||
| (3). Li et al., J. Immunol., 2013 Lymphatic tissue |
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| Acute Fold Change | Acute P Value | Asymt Fold Change | Asypt P Value | AIDS Fold Change | AIDS P Value |
| unknown | unknown | unknown | unknown | unknown | unknown |
| (4). Chang et al., MBio., 2011 Transcriptome analysis of T-cell line (Sup T1) Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation |
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| Up-regulated (True) | TRUE | ||||
| (5). Sherrill-Mix et al., BMC Retrovirol., 2015 Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based |
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| Test Status | Log2 Fold Change | P Value | |||
| OK | -0.76898 | 0.000305467 | |||
| (6). Rotger et al., PLoS Pathog., 2010 Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient (Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach) |
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| Log2 Fold Change | P Value | ||||
| unknown | unknown | ||||
Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV
| (1). Greenwood et al., Elife, 2016 Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset |
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| 6 h | 24 h | 48 h | 72 h | RTi | ||
| unknown | unknown | unknown | unknown | unknown | ||
| (2). Navare et al., Virology, 2012 SUP-T1 cell line |
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| FC-4hpi | P-value | FC-8hpi | P-value | FC-20hpi | P-value | Category |
| unknown | unknown | unknown | unknown | unknown | unknown | unknown |
| (3). Hyrcza et al., J. Virolo., 2007 Primary human CD4+ and CD8+ T Cells |
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| Affymetrix Prob ID | Fold Change | In CD8? | Category | |||
| 220054_at | 1.53 | No | downregulated in CD8+ cells | |||
Protein Overview top
Drug-protein Interaction (annotations from DrugBank) top
Protein Secondary Structure (annotations from PDB) top
HIV-1 Interaction (annotations from NCBI HIV-1 Interaction Database) top
Metabolic/Signalling Pathway (annotations from KEGG database) top
| Pathway Accession Number | Description |
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| hsa04060 | Cytokine-cytokine receptor interaction - Homo sapiens (human) |
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| hsa04630 | Jak-STAT signaling pathway - Homo sapiens (human) |
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| hsa04659 | Th17 cell differentiation - Homo sapiens (human) |
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| hsa05133 | Pertussis - Homo sapiens (human) |
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| hsa05152 | Tuberculosis - Homo sapiens (human) |
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| hsa05321 | Inflammatory bowel disease (IBD) - Homo sapiens (human) |
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| hsa05323 | Rheumatoid arthritis - Homo sapiens (human) |
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