Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0001419
UniProt IDQ9NPF7
Primary gene name(s)IL23A
Synonym gene name(s)SGRF
Protein nameInterleukin-23 subunit alpha
Protein functionAssociates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis. {ECO:0000269|PubMed:11114383, ECO:0000269|PubMed:12023369, ECO:0000269|PubMed:16424222}.
Subcellular locationSecreted {ECO:0000269|PubMed:11114383}. Note=Secreted upon association with IL12B.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q9NPF7
Gene Ontology
(Biological Process)
Complete annatation
defense response to Gram-negative bacterium [GO:0050829];
defense response to virus [GO:0051607];
inflammatory response [GO:0006954];
innate immune response [GO:0045087];
negative regulation of interleukin-10 production [GO:0032693];
positive regulation of activated T cell proliferation [GO:0042104];
positive regulation of activation of JAK2 kinase activity [GO:0010535];
positive regulation of defense response to virus by host [GO:0002230];
positive regulation of granulocyte macrophage colony-stimulating factor production [GO:0032725];
positive regulation of inflammatory response [GO:0050729];
positive regulation of interferon-gamma production [GO:0032729];
positive regulation of interleukin-10 production [GO:0032733];
positive regulation of interleukin-12 production [GO:0032735];
positive regulation of interleukin-17 production [GO:0032740];
positive regulation of memory T cell differentiation [GO:0043382];
positive regulation of natural killer cell activation [GO:0032816];
positive regulation of natural killer cell proliferation [GO:0032819];
positive regulation of neutrophil chemotaxis [GO:0090023];
positive regulation of NF-kappaB import into nucleus [GO:0042346];
positive regulation of NK T cell activation [GO:0051135];
positive regulation of NK T cell proliferation [GO:0051142];
positive regulation of osteoclast differentiation [GO:0045672];
positive regulation of T cell mediated cytotoxicity [GO:0001916];
positive regulation of T cell proliferation [GO:0042102];
positive regulation of T-helper 17 cell lineage commitment [GO:2000330];
positive regulation of T-helper 17 type immune response [GO:2000318];
positive regulation of T-helper 1 type immune response [GO:0002827];
positive regulation of tissue remodeling [GO:0034105];
positive regulation of transcription from RNA polymerase II promoter [GO:0045944];
positive regulation of tumor necrosis factor production [GO:0032760];
positive regulation of tyrosine phosphorylation of Stat3 protein [GO:0042517];
positive regulation of tyrosine phosphorylation of Stat4 protein [GO:0042520];
positive regulation of tyrosine phosphorylation of Stat5 protein [GO:0042523];
regulation of tyrosine phosphorylation of Stat1 protein [GO:0042510];
T cell proliferation [GO:0042098];
tissue remodeling [GO:0048771]
Gene Ontology
(Molecular Function)
Complete annatation
unknown
Gene Ontology
(Cellular Component)
Complete annatation
extracellular region [GO:0005576];
interleukin-23 complex [GO:0070743]
Protein-protein interaction119611
Phylogenetic treeQ9NPF7
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
      unknown
Brass et al., Science, 2008
      unknown
Smith et al., J. Immunol, 2010
      unknown
Interferon-stimulated
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model


DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD30.9771008035904410.003464908817969460.0106512554975394
AZA vs. DISU0.2421669578196810.3501666798200560.887429206006287
AZA vs. IL7-0.2875836439169810.1548896758437040.922020841096286
AZA vs. SAHA-1.002503480165860.00010060429663350.00380077485577287
DISU vs. CD3-0.7492745897289160.040802299239640.0916622740295578
DISU vs. IL7-0.5392498047415310.0372234964999740.253162530269032
DISU vs. SAHA-1.243283065049115.01798981333845e-050.00224409864916391
DMSO vs. AZA-0.01681012253889680.9247689201162141
DMSO vs. CD3-1.011081132691650.001945906330545810.00609081214828021
DMSO vs. DISU-0.2622553183867590.293909162562480.806677299793064
DMSO vs. IL7-0.2631667695277940.1649082344104080.672769899107559
DMSO vs. SAHA-0.9909549856290516.89839257108638e-050.00268645153588741
HIV vs. Mock in Activation0.45062030721810.471611734288060.999983755607037
HIV vs. Mock in Latency-0.3880252793380240.02409087299434710.586947535290621
IL7 vs. CD3-1.257476050813960.000138918863673010.000778989595291398
SAHA vs. CD3-2.005215952923649.30158313705576e-089.84374001934201e-07
SAHA vs. IL7-0.7208021159862220.005004679020365170.0384312437865433
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) TRUE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -0.76898 0.000305467
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
220054_at 1.53 No downregulated in CD8+ cells

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

Drugbank ID Drug Name Drug Status Pharmacological Action Drug Action
DB05459 Briakinumab investigational unknown unknown
DB05679 Ustekinumab approved, investigational yes unknown

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
3D85 X-ray 1.9Å C=20-189.
3D87 X-ray 2.9Å A/C=20-189.
3DUH X-ray 2.3Å C/D=20-189.
3QWR X-ray 3.2Å B=20-189.
4GRW X-ray 2.5Å A/C=1-189.
4OE8 X-ray 1.7Å B=1-189.
4OG9 X-ray 3.3Å B=1-189.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Envelope surface glycoprotein gp120 interacts with 25234720
Envelope surface glycoprotein gp120 upregulates 25234720

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human)
hsa04630 Jak-STAT signaling pathway - Homo sapiens (human)
hsa04659 Th17 cell differentiation - Homo sapiens (human)
hsa05133 Pertussis - Homo sapiens (human)
hsa05152 Tuberculosis - Homo sapiens (human)
hsa05321 Inflammatory bowel disease (IBD) - Homo sapiens (human)
hsa05323 Rheumatoid arthritis - Homo sapiens (human)
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