Database ID | HIV0001419 |
UniProt ID | Q9NPF7 |
Primary gene name(s) | IL23A |
Synonym gene name(s) | SGRF |
Protein name | Interleukin-23 subunit alpha |
Protein function | Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis. {ECO:0000269|PubMed:11114383, ECO:0000269|PubMed:12023369, ECO:0000269|PubMed:16424222}. |
Subcellular location | Secreted {ECO:0000269|PubMed:11114383}. Note=Secreted upon association with IL12B. |
ECO code | Click here for more information. |
Amino acid sequence FASTA format: Q9NPF7 |
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Gene Ontology (Biological Process) Complete annatation | defense response to Gram-negative bacterium [GO:0050829]; defense response to virus [GO:0051607]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; negative regulation of interleukin-10 production [GO:0032693]; positive regulation of activated T cell proliferation [GO:0042104]; positive regulation of activation of JAK2 kinase activity [GO:0010535]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of granulocyte macrophage colony-stimulating factor production [GO:0032725]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interferon-gamma production [GO:0032729]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-17 production [GO:0032740]; positive regulation of memory T cell differentiation [GO:0043382]; positive regulation of natural killer cell activation [GO:0032816]; positive regulation of natural killer cell proliferation [GO:0032819]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of NF-kappaB import into nucleus [GO:0042346]; positive regulation of NK T cell activation [GO:0051135]; positive regulation of NK T cell proliferation [GO:0051142]; positive regulation of osteoclast differentiation [GO:0045672]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of T-helper 17 cell lineage commitment [GO:2000330]; positive regulation of T-helper 17 type immune response [GO:2000318]; positive regulation of T-helper 1 type immune response [GO:0002827]; positive regulation of tissue remodeling [GO:0034105]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of tyrosine phosphorylation of Stat3 protein [GO:0042517]; positive regulation of tyrosine phosphorylation of Stat4 protein [GO:0042520]; positive regulation of tyrosine phosphorylation of Stat5 protein [GO:0042523]; regulation of tyrosine phosphorylation of Stat1 protein [GO:0042510]; T cell proliferation [GO:0042098]; tissue remodeling [GO:0048771] |
Gene Ontology (Molecular Function) Complete annatation | unknown |
Gene Ontology (Cellular Component) Complete annatation | extracellular region [GO:0005576]; interleukin-23 complex [GO:0070743] |
Protein-protein interaction | 119611 |
Phylogenetic tree | Q9NPF7 |
HIV replication factor status |
Zhou et al., Cell. Host. Microbe., 2008 unknown Brass et al., Science, 2008 unknown Smith et al., J. Immunol, 2010 unknown |
Interferon-stimulated gene status |
Lu et al., J. Virol., 2011 Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown; Schoggins JW and Rice CM, Curr. Opin. Virol., 2011 Targeted viruses: unknown Viral life cycle: unknown Mechanism related to antiviral activity: unknown |
Anti-viral restriction factor |
Liu et al., Retrovirology, 2011 unknown (Triplicates) |
Up-regulated;
Down-regulated
For brief introduction to each study, please go to the help page.
(1). Mohammadi et al., PLoS Pathog., 2014 Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model DMSO: Dimethyl suloxyde (negative control) - 0.0033% final SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies IL7: Interleukin-7 based stimulation DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM |
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Experimental Condition | Log2 Fold Change | P value | Adjusted P value |
AZA vs. CD3 | 0.977100803590441 | 0.00346490881796946 | 0.0106512554975394 |
AZA vs. DISU | 0.242166957819681 | 0.350166679820056 | 0.887429206006287 |
AZA vs. IL7 | -0.287583643916981 | 0.154889675843704 | 0.922020841096286 |
AZA vs. SAHA | -1.00250348016586 | 0.0001006042966335 | 0.00380077485577287 |
DISU vs. CD3 | -0.749274589728916 | 0.04080229923964 | 0.0916622740295578 |
DISU vs. IL7 | -0.539249804741531 | 0.037223496499974 | 0.253162530269032 |
DISU vs. SAHA | -1.24328306504911 | 5.01798981333845e-05 | 0.00224409864916391 |
DMSO vs. AZA | -0.0168101225388968 | 0.924768920116214 | 1 |
DMSO vs. CD3 | -1.01108113269165 | 0.00194590633054581 | 0.00609081214828021 |
DMSO vs. DISU | -0.262255318386759 | 0.29390916256248 | 0.806677299793064 |
DMSO vs. IL7 | -0.263166769527794 | 0.164908234410408 | 0.672769899107559 |
DMSO vs. SAHA | -0.990954985629051 | 6.89839257108638e-05 | 0.00268645153588741 |
HIV vs. Mock in Activation | 0.4506203072181 | 0.47161173428806 | 0.999983755607037 |
HIV vs. Mock in Latency | -0.388025279338024 | 0.0240908729943471 | 0.586947535290621 |
IL7 vs. CD3 | -1.25747605081396 | 0.00013891886367301 | 0.000778989595291398 |
SAHA vs. CD3 | -2.00521595292364 | 9.30158313705576e-08 | 9.84374001934201e-07 |
SAHA vs. IL7 | -0.720802115986222 | 0.00500467902036517 | 0.0384312437865433 |
(2). Iglesias-Ussel et al., J. Virol., 2013 Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model |
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Log2 Fold Change | P Value | ||
unknown | unknown |
(1). Imbeault et al., PloS Pathog., 2012 Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells |
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Experiment type | Log2 Fold Change | P Value | Adjusted P Value | ||
Infected vs. Mock | unknown | unknown | unknown | ||
Infected vs. Bystander | unknown | unknown | unknown | ||
(2). Lefebvre et al., J. Virol., 2011 Transcriptome analysis of T-cell line (Sup T1) |
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Log2 Fold Change | unknown | ||||
(3). Li et al., J. Immunol., 2013 Lymphatic tissue |
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Acute Fold Change | Acute P Value | Asymt Fold Change | Asypt P Value | AIDS Fold Change | AIDS P Value |
unknown | unknown | unknown | unknown | unknown | unknown |
(4). Chang et al., MBio., 2011 Transcriptome analysis of T-cell line (Sup T1) Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation |
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Up-regulated (True) | TRUE | ||||
(5). Sherrill-Mix et al., BMC Retrovirol., 2015 Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based |
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Test Status | Log2 Fold Change | P Value | |||
OK | -0.76898 | 0.000305467 | |||
(6). Rotger et al., PLoS Pathog., 2010 Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient (Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach) |
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Log2 Fold Change | P Value | ||||
unknown | unknown |
(1). Greenwood et al., Elife, 2016 Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset |
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6 h | 24 h | 48 h | 72 h | RTi | ||
unknown | unknown | unknown | unknown | unknown | ||
(2). Navare et al., Virology, 2012 SUP-T1 cell line |
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FC-4hpi | P-value | FC-8hpi | P-value | FC-20hpi | P-value | Category |
unknown | unknown | unknown | unknown | unknown | unknown | unknown |
(3). Hyrcza et al., J. Virolo., 2007 Primary human CD4+ and CD8+ T Cells |
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Affymetrix Prob ID | Fold Change | In CD8? | Category | |||
220054_at | 1.53 | No | downregulated in CD8+ cells |
Pathway Accession Number | Description |
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hsa04060 | Cytokine-cytokine receptor interaction - Homo sapiens (human) |
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hsa04630 | Jak-STAT signaling pathway - Homo sapiens (human) |
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hsa04659 | Th17 cell differentiation - Homo sapiens (human) |
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hsa05133 | Pertussis - Homo sapiens (human) |
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hsa05152 | Tuberculosis - Homo sapiens (human) |
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hsa05321 | Inflammatory bowel disease (IBD) - Homo sapiens (human) |
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hsa05323 | Rheumatoid arthritis - Homo sapiens (human) |
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