Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0001417
UniProt IDQ9NPH3
Primary gene name(s)IL1RAP
Synonym gene name(s)C3orf13, IL1R3
Protein nameInterleukin-1 receptor accessory protein
Protein functionCoreceptor for IL1RL2 in the IL-36 signaling system, By similarity. Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Coreceptor for IL1RL1 in the IL-33 signaling system. {ECO:0000250|UniProtKB:Q61730, ECO:0000269|PubMed:10799889, ECO:0000269|PubMed:9371760, ECO:0000305|PubMed:19836339}.; FUNCTION: Isoform 2: Associates with secreted ligand-bound IL1R2 and increases the affinity of secreted IL1R2 for IL1B; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors, PubMed:12530978. Enhances the ability of secreted IL1R1 to inhibit IL-33 signaling, By similarity. {ECO:0000250|UniProtKB:Q61730, ECO:0000269|PubMed:12530978}.; FUNCTION: Isoform 4: Unable to mediate canonical IL-1 signaling, PubMed:19481478. Required for Src phosphorylation by IL1B. May be involved in IL1B-potentiated NMDA-induced calcium influx in neurons, By similarity. {ECO:0000250|UniProtKB:Q61730, ECO:0000269|PubMed:19481478}.
Subcellular locationIsoform 1: Cell membrane;
Single-pass type I membrane protein.;
SUBCELLULAR LOCATION: Isoform 2: Secreted.;
SUBCELLULAR LOCATION: Isoform 3: Secreted.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q9NPH3
Gene Ontology
(Biological Process)
Complete annatation
immune response [GO:0006955];
inflammatory response [GO:0006954];
innate immune response [GO:0045087];
interleukin-2 biosynthetic process [GO:0042094];
interleukin-4 secretion [GO:0072602];
positive regulation of dendrite development [GO:1900006];
positive regulation of interleukin-13 production [GO:0032736];
positive regulation of interleukin-5 production [GO:0032754];
positive regulation of interleukin-6 secretion [GO:2000778];
positive regulation of NF-kappaB transcription factor activity [GO:0051092];
positive regulation of synapse assembly [GO:0051965];
protein complex assembly [GO:0006461]
Gene Ontology
(Molecular Function)
Complete annatation
interleukin-1 receptor activity [GO:0004908];
signal transducer activity [GO:0004871]
Gene Ontology
(Cellular Component)
Complete annatation
cytoplasm [GO:0005737];
extracellular region [GO:0005576];
integral component of plasma membrane [GO:0005887];
membrane [GO:0016020];
plasma membrane [GO:0005886];
protein complex [GO:0043234]
Protein-protein interaction109771
Phylogenetic treeQ9NPH3
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-0.8761708236175760.008598644133236630.0229948126998124
AZA vs. DISU-0.1342284981445170.6003688314323040.955158276076142
AZA vs. IL7-0.1157161889648270.5563422892030880.999311006273513
AZA vs. SAHA0.5633550468965450.0231566717560620.169778049635641
DISU vs. CD30.7304206761532320.04637297456043930.101720928190347
DISU vs. IL70.01020262697573140.9680716867904990.995379686713869
DISU vs. SAHA0.6978156635188030.01875900612390670.155978220344416
DMSO vs. AZA-0.07003540014523430.6850499528972641
DMSO vs. CD30.7933298762561950.01469176303237710.0345183109923207
DMSO vs. DISU0.06204644584415390.8017785038400240.977285200264502
DMSO vs. IL7-0.03834399817175430.8351313708276140.963494783989913
DMSO vs. SAHA0.6262604025852610.00903491197427020.0843650299654437
HIV vs. Mock in Activation-0.2656396121073070.6741411810321190.999983755607037
HIV vs. Mock in Latency-0.2759295102240080.1025733721885610.999834320637052
IL7 vs. CD30.7703551886914090.01820845657773560.0485419288992234
SAHA vs. CD31.413756719657270.0001113989088959990.000530085745836028
SAHA vs. IL70.674736651155160.006604731477905190.0469178710169382
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) TRUE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.404454 0.00913982
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
3O4O X-ray 3.3Å B=21-350.
4DEP X-ray 3.1Å C/F=21-367.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human)
hsa04659 Th17 cell differentiation - Homo sapiens (human)
hsa04750 Inflammatory mediator regulation of TRP channels - Homo sapiens (human)