Protein Information (annotations from UniProt)
| Database ID | HIV0001416 |
| UniProt ID | Q14005 |
| Primary gene name(s) | IL16 |
| Synonym gene name(s) | unknown |
| Protein name | Pro-interleukin-16 [Cleaved into: Interleukin-16 |
| Protein function | Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.; FUNCTION: Isoform 1 may act as a scaffolding protein that anchors ion channels in the membrane.; FUNCTION: Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1, the DNA-binding subunit the GABP transcription factor complex and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells. |
| Subcellular location | Interleukin-16: Secreted.; SUBCELLULAR LOCATION: Isoform 1: Cytoplasm {ECO:0000250}.; SUBCELLULAR LOCATION: Isoform 3: Cytoplasm. Nucleus. |
| ECO code | Click here for more information. |
| Amino acid sequence FASTA format: Q14005 |
|
| Gene Ontology (Biological Process) Complete annatation | immune response [GO:0006955]; induction of positive chemotaxis [GO:0050930]; leukocyte chemotaxis [GO:0030595]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]; viral process [GO:0016032] |
| Gene Ontology (Molecular Function) Complete annatation | unknown |
| Gene Ontology (Cellular Component) Complete annatation | cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nucleus [GO:0005634]; plasma membrane [GO:0005886] |
| Protein-protein interaction | 109816 |
| Phylogenetic tree | Q14005 |
| HIV replication factor status |
Zhou et al., Cell. Host. Microbe., 2008 unknown Brass et al., Science, 2008 unknown Smith et al., J. Immunol, 2010 unknown |
| Interferon-stimulated gene status |
Lu et al., J. Virol., 2011 Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown; Schoggins JW and Rice CM, Curr. Opin. Virol., 2011 Targeted viruses: unknown Viral life cycle: unknown Mechanism related to antiviral activity: unknown |
| Anti-viral restriction factor |
Liu et al., Retrovirology, 2011 unknown (Triplicates) |
Gene Expression Profile top
Up-regulated; 
Down-regulated
For brief introduction to each study, please go to the help page.
Gene expression during HIV latency
| (1). Mohammadi et al., PLoS Pathog., 2014 Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model DMSO: Dimethyl suloxyde (negative control) - 0.0033% final SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies IL7: Interleukin-7 based stimulation DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM |
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| Experimental Condition | Log2 Fold Change | P value | Adjusted P value |
| AZA vs. CD3 | -3.58542478567124 | 0 | 0 |
| AZA vs. DISU | -0.447367040821669 | 0.0767621136948096 | 0.590222266291186 |
| AZA vs. IL7 | -0.406342686078678 | 0.0341757316007514 | 0.570633544062172 |
| AZA vs. SAHA | -0.366117498564597 | 0.13353917013874 | 0.465611727724867 |
| DISU vs. CD3 | 3.12712136817712 | 1.88737914186277e-15 | 1.07359823337507e-13 |
| DISU vs. IL7 | 0.0314467569373392 | 0.900405737366161 | 0.981671743384553 |
| DISU vs. SAHA | 0.0831743803881074 | 0.775358368438547 | 0.937534176086115 |
| DMSO vs. AZA | 0.00896360462171178 | 0.95711975637023 | 1 |
| DMSO vs. CD3 | 3.5820958346844 | 0 | 0 |
| DMSO vs. DISU | 0.454268451067047 | 0.0624900399059141 | 0.477423609620826 |
| DMSO vs. IL7 | -0.407850451976186 | 0.0230236887524558 | 0.309618294329412 |
| DMSO vs. SAHA | -0.380228050003474 | 0.106746208124724 | 0.38704792501964 |
| HIV vs. Mock in Activation | -0.284909764666187 | 0.647862577274963 | 0.999983755607037 |
| HIV vs. Mock in Latency | 0.129678370225858 | 0.429911391226834 | 0.999834320637052 |
| IL7 vs. CD3 | 3.18558306214297 | 0 | 0 |
| SAHA vs. CD3 | 3.19617267524832 | 1.11022302462516e-16 | 6.17382324025871e-15 |
| SAHA vs. IL7 | 0.0377188737256597 | 0.876833913591305 | 0.95073747793538 |
| (2). Iglesias-Ussel et al., J. Virol., 2013 Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model |
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| Log2 Fold Change | P Value | ||
| unknown | unknown | ||
Gene expression during HIV infection and replication
| (1). Imbeault et al., PloS Pathog., 2012 Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells |
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| Experiment type | Log2 Fold Change | P Value | Adjusted P Value | ||
| Infected vs. Mock | unknown | unknown | unknown | ||
| Infected vs. Bystander | unknown | unknown | unknown | ||
| (2). Lefebvre et al., J. Virol., 2011 Transcriptome analysis of T-cell line (Sup T1) |
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| Log2 Fold Change | unknown | ||||
| (3). Li et al., J. Immunol., 2013 Lymphatic tissue |
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| Acute Fold Change | Acute P Value | Asymt Fold Change | Asypt P Value | AIDS Fold Change | AIDS P Value |
| unknown | unknown | unknown | unknown | unknown | unknown |
| (4). Chang et al., MBio., 2011 Transcriptome analysis of T-cell line (Sup T1) Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation |
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| Up-regulated (True) | FALSE | ||||
| (5). Sherrill-Mix et al., BMC Retrovirol., 2015 Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based |
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| Test Status | Log2 Fold Change | P Value | |||
| OK | -0.911533 | 0.000305467 | |||
| (6). Rotger et al., PLoS Pathog., 2010 Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient (Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach) |
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| Log2 Fold Change | P Value | ||||
| unknown | unknown | ||||
Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV
| (1). Greenwood et al., Elife, 2016 Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset |
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| 6 h | 24 h | 48 h | 72 h | RTi | ||
| 1.131 | 1.191 | 1.232 | 1.316 | 1.283 | ||
| (2). Navare et al., Virology, 2012 SUP-T1 cell line |
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| FC-4hpi | P-value | FC-8hpi | P-value | FC-20hpi | P-value | Category |
| unknown | unknown | unknown | unknown | unknown | unknown | unknown |
| (3). Hyrcza et al., J. Virolo., 2007 Primary human CD4+ and CD8+ T Cells |
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| Affymetrix Prob ID | Fold Change | In CD8? | Category | |||
| unknown | unknown | unknown | unknown | |||
Protein Overview top
Drug-protein Interaction (annotations from DrugBank) top
Protein Secondary Structure (annotations from PDB) top
HIV-1 Interaction (annotations from NCBI HIV-1 Interaction Database) top
Metabolic/Signalling Pathway (annotations from KEGG database) top
| Pathway Accession Number | Description | not found |
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