Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0001414
UniProt IDQ08334
Primary gene name(s)IL10RB
Synonym gene name(s)CRFB4, D21S58, D21S66
Protein nameInterleukin-10 receptor subunit beta
Protein functionShared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IFNL1. The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes, ISG, which contribute to the antiviral state. {ECO:0000269|PubMed:12469119, ECO:0000269|PubMed:15123776}.
Subcellular locationMembrane;
Single-pass type I membrane protein.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q08334
Gene Ontology
(Biological Process)
Complete annatation
cytokine-mediated signaling pathway [GO:0019221];
defense response to virus [GO:0051607];
immune response [GO:0006955];
inflammatory response [GO:0006954];
signal transduction [GO:0007165]
Gene Ontology
(Molecular Function)
Complete annatation
receptor activity [GO:0004872]
Gene Ontology
(Cellular Component)
Complete annatation
extracellular exosome [GO:0070062];
integral component of membrane [GO:0016021];
interleukin-28 receptor complex [GO:0032002];
plasma membrane [GO:0005886]
Protein-protein interaction109802
Phylogenetic treeQ08334
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-1.275497511222350.0001624522004998190.000739945471723562
AZA vs. DISU-0.2876155751650370.2588683084310450.839581352451412
AZA vs. IL7-0.1806402494936280.3527151565319360.999311006273513
AZA vs. SAHA-0.2612231833064010.2886941629269720.660951602348521
DISU vs. CD30.9758534105789440.009216771173682030.0270614742251817
DISU vs. IL70.0971363570519370.702071807096010.923741138299926
DISU vs. SAHA0.02834170487049730.9228343990099720.982517142063809
DMSO vs. AZA-0.1524113692727380.3698286320136711
DMSO vs. CD31.111693527671520.0007366529156882520.00261916521539094
DMSO vs. DISU0.1332384121373320.5874812504701820.934701463289767
DMSO vs. IL7-0.02109376406707080.9077158065090160.98028625138788
DMSO vs. SAHA-0.1145771027510940.629965411744880.879289935978229
HIV vs. Mock in Activation-0.09472888197426630.8954141224770160.999983755607037
HIV vs. Mock in Latency0.01978345908220990.9055430479706840.999834320637052
IL7 vs. CD31.101577692777070.0008207849198051950.00358288186974333
SAHA vs. CD30.9899894497793380.007051239430722830.0191119025577326
SAHA vs. IL7-0.08264058123868220.7371713970636610.880588157184879
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) TRUE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -0.504196 0.000305467
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
3LQM X-ray 2.1Å A/B=20-220.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human)
hsa04630 Jak-STAT signaling pathway - Homo sapiens (human)
hsa05145 Toxoplasmosis - Homo sapiens (human)
hsa05152 Tuberculosis - Homo sapiens (human)
hsa05169 Epstein-Barr virus infection - Homo sapiens (human)