Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0001407
UniProt IDP22692
Primary gene name(s)IGFBP4
Synonym gene name(s)IBP4
Protein nameInsulin-like growth factor-binding protein 4
Protein functionIGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
Subcellular locationSecreted.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P22692
Gene Ontology
(Biological Process)
Complete annatation
cell proliferation [GO:0008283];
cellular protein metabolic process [GO:0044267];
DNA metabolic process [GO:0006259];
inflammatory response [GO:0006954];
negative regulation of canonical Wnt signaling pathway [GO:0090090];
positive regulation of insulin-like growth factor receptor signaling pathway [GO:0043568];
positive regulation of MAPK cascade [GO:0043410];
regulation of cell growth [GO:0001558];
regulation of glucose metabolic process [GO:0010906];
regulation of insulin-like growth factor receptor signaling pathway [GO:0043567];
signal transduction [GO:0007165];
skeletal system development [GO:0001501];
type B pancreatic cell proliferation [GO:0044342]
Gene Ontology
(Molecular Function)
Complete annatation
insulin-like growth factor I binding [GO:0031994];
insulin-like growth factor II binding [GO:0031995];
receptor binding [GO:0005102]
Gene Ontology
(Cellular Component)
Complete annatation
extracellular region [GO:0005576];
extracellular space [GO:0005615]
Protein-protein interaction109708
Phylogenetic treeP22692
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD30.7484875855321640.2190250366222130.327170005150644
AZA vs. DISU-0.8923902427556760.0005337704278228770.0532851352914043
AZA vs. IL70.4638372043142090.04435345305177530.634897035201005
AZA vs. SAHA-0.8642621062495780.0005601993183185220.0138433516792351
DISU vs. CD3-1.651300172216530.01044411402834190.0300275748356333
DISU vs. IL71.347780994848782.45869735238102e-074.02878941164608e-05
DISU vs. SAHA0.02835084723377410.9233222933481340.982517142063809
DMSO vs. AZA-0.1654646446105840.3314167922411241
DMSO vs. CD3-0.9271992112389370.1265633697746930.206618678549605
DMSO vs. DISU0.7244770902067240.003497727618778310.126537826154312
DMSO vs. IL70.637175165895940.004374778163808820.133863185791214
DMSO vs. SAHA-0.7052860456904740.003511359718468610.0431293417416792
HIV vs. Mock in Activation-0.5164892149921790.6937731386958560.999983755607037
HIV vs. Mock in Latency-0.4601018952139650.1260827552124820.999834320637052
IL7 vs. CD3-0.2753469795354940.6624067435675680.768086921893773
SAHA vs. CD3-1.638641365556970.01429920566507970.0346779899215885
SAHA vs. IL7-1.331243617093616.79953709625813e-060.000225762603940518
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change 2.284664086
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) TRUE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -0.568431 0.000305467
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
1.015 1.234 1.082 1.308 0.937
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
1WQJ X-ray 1.6Å B=24-103.
2DSP X-ray 2.5Å B=22-113.
2DSQ X-ray 2.8Å A/B=22-113.
2DSR X-ray 2.1Å B=24-103# G=172-253.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Tat binds 7778269

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
not found