Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0001406
UniProt IDQ9Y6M1
Primary gene name(s)IGF2BP2
Synonym gene name(s)IMP2, VICKZ2
Protein nameInsulin-like growth factor 2 mRNA-binding protein 2
Protein functionRNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes, mRNPs. This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation, By similarity. Binds to the 5'-UTR of the insulin-like growth factor 2, IGF2 mRNAs. Binding is isoform-specific. Binds to beta-actin/ACTB and MYC transcripts. {ECO:0000250, ECO:0000269|PubMed:23640942, ECO:0000269|PubMed:9891060}.
Subcellular locationNucleus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Localizes at the connecting piece and the tail of the spermatozoa. In response to cellular stress, such as oxidative stress, recruited to stress granules.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q9Y6M1
Gene Ontology
(Biological Process)
Complete annatation
anatomical structure morphogenesis [GO:0009653];
gene expression [GO:0010467];
mRNA transport [GO:0051028];
negative regulation of translation [GO:0017148];
regulation of cytokine biosynthetic process [GO:0042035]
Gene Ontology
(Molecular Function)
Complete annatation
mRNA 3'-UTR binding [GO:0003730];
mRNA 5'-UTR binding [GO:0048027];
nucleotide binding [GO:0000166];
poly(A RNA binding [GO:0044822];
translation regulator activity [GO:0045182]
Gene Ontology
(Cellular Component)
Complete annatation
cytoplasm [GO:0005737];
cytoskeleton [GO:0005856];
cytosol [GO:0005829];
nucleus [GO:0005634]
Protein-protein interaction115888
Phylogenetic treeQ9Y6M1
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
      unknown
Brass et al., Science, 2008
      unknown
Smith et al., J. Immunol, 2010
      unknown
Interferon-stimulated
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model


DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-1.026953254819710.1900166125845030.293165153533998
AZA vs. DISU-0.07161704225649660.908922919518340.994259558276858
AZA vs. IL7-0.4847227259230630.4193727748893360.999311006273513
AZA vs. SAHA0.1066655122976010.8422253252035930.962230849025062
DISU vs. CD30.9383473358172720.2107856716591650.332084366073396
DISU vs. IL7-0.4224256583472140.4599367179931530.802163237552991
DISU vs. SAHA0.1814514722426960.7171310133664090.916543546679541
DMSO vs. AZA-0.179844070656380.7580244110754491
DMSO vs. CD30.8321802128032210.21697813743020.318926900489253
DMSO vs. DISU-0.1102155197668920.8414280675833020.982583769983649
DMSO vs. IL7-0.2979554574422810.5649400447669390.902347727583891
DMSO vs. SAHA0.2803892866480970.5186162100568160.822743673870134
HIV vs. Mock in Activation-0.09521394108575440.9348840902581470.999983755607037
HIV vs. Mock in Latency-0.2621681647215970.6529389614162650.999834320637052
IL7 vs. CD30.5458335961141440.4418859701233470.576444869803749
SAHA vs. CD31.107228332889890.06813427967485230.1279321697857
SAHA vs. IL70.5896738348613380.2036888763770880.436986816728717
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) TRUE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 1.41494 0.000305467
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
2CQH NMR - A=2-81.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Rev inhibited by 19726068
Pr55(Gag) interacts with 25010285

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
not found
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