Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0001402
UniProt IDP13164
Primary gene name(s)IFITM1
Synonym gene name(s)CD225, IFI17
Protein nameInterferon-induced transmembrane protein 1
Protein functionIFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronavirus, SARS-CoV, Marburg virus, MARV, Ebola virus, EBOV, Dengue virus, DNV, West Nile virus, WNV, human immunodeficiency virus type 1, HIV-1 and hepatitis C virus, HCV. Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry and SARS-CoV S protein-mediated viral entry. Also implicated in cell adhesion and control of cell growth and migration. Plays a key role in the antiproliferative action of IFN-gamma either by inhibiting the ERK activation or by arresting cell growth in G1 phase in a p53-dependent manner. Acts as a positive regulator of osteoblast differentiation. {ECO:0000269|PubMed:16847454, ECO:0000269|PubMed:20064371, ECO:0000269|PubMed:20838853, ECO:0000269|PubMed:21177806, ECO:0000269|PubMed:21253575, ECO:0000269|PubMed:21976647, ECO:0000269|PubMed:22479637, ECO:0000269|PubMed:22634173}.
Subcellular locationCell membrane {ECO:0000269|PubMed:19499152, ECO:0000269|PubMed:25105503};
Single-pass membrane protein {ECO:0000269|PubMed:19499152}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P13164
Gene Ontology
(Biological Process)
Complete annatation
cell surface receptor signaling pathway [GO:0007166];
defense response to virus [GO:0051607];
negative regulation of cell migration [GO:0030336];
negative regulation of cell proliferation [GO:0008285];
negative regulation of viral entry into host cell [GO:0046597];
negative regulation of viral genome replication [GO:0045071];
ossification [GO:0001503];
positive regulation of osteoblast differentiation [GO:0045669];
regulation of immune response [GO:0050776];
response to interferon-alpha [GO:0035455];
response to interferon-beta [GO:0035456];
response to interferon-gamma [GO:0034341];
response to virus [GO:0009615];
type I interferon signaling pathway [GO:0060337]
Gene Ontology
(Molecular Function)
Complete annatation
receptor signaling protein activity [GO:0005057]
Gene Ontology
(Cellular Component)
Complete annatation
integral component of membrane [GO:0016021];
membrane [GO:0016020];
plasma membrane [GO:0005886]
Protein-protein interaction114091
Phylogenetic treeP13164
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
      unknown
Brass et al., Science, 2008
      unknown
Smith et al., J. Immunol, 2010
      unknown
Interferon-stimulated
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: 13.5434276; Folds changes 16h: 7.133242402; Tested: tested;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: DENV; filovirus; FLUAV; HIV-1; SARS-CoV; VSV; WNV; YFV
      Viral life cycle: entry
      Mechanism related to antiviral activity: unknown; possibly target enodyctic pathway
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model


DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-2.60475448832096.07291994469961e-141.75011566742854e-12
AZA vs. DISU-0.6127345865622910.03723537489657740.445818936609219
AZA vs. IL70.1570988387465210.4136620617857070.999311006273513
AZA vs. SAHA-0.632619453156320.04471148571160170.251955489950162
DISU vs. CD31.98191998018231.29354052358366e-071.54507368086371e-06
DISU vs. IL70.7595651460351450.004923072179851330.0747583195653716
DISU vs. SAHA-0.01686254288543520.9630139146944050.992637214624418
DMSO vs. AZA-0.003935968084496570.982157171896381
DMSO vs. CD32.590254947642712.04281036531029e-145.75232488848589e-13
DMSO vs. DISU0.6073976241973250.01924843410582880.285609257234888
DMSO vs. IL70.1679774626110990.3488786971615710.81588697150311
DMSO vs. SAHA-0.6327716950015860.02512605058711290.164469246984394
HIV vs. Mock in Activation-0.00272106181872220.9965119583589160.999983755607037
HIV vs. Mock in Latency0.01467761868080090.9624385565528670.999834320637052
IL7 vs. CD32.766738273815417.7715611723761e-163.52833558889232e-14
SAHA vs. CD31.951836925918479.58926403837879e-081.01268541736768e-06
SAHA vs. IL7-0.789860804127810.007261808211049710.0501813137333484
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
1.8 0.001041428 1.2 0.016652619 1.5 0.045550277
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) FALSE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.404325 0.0017721
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
0.211 0.007

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Vif downregulated by 23376165
24076421
Pr55(Gag) incorporates 25422070
25464829
Envelope surface glycoprotein gp120 interacts with 26387945
Envelope transmembrane glycoprotein gp41 interacts with 26387945
Pr55(Gag) co-localizes with 25422070
Pr55(Gag) downregulated by 23376165
24076421
24725927
Tat upregulates 23898208
24076421
Envelope surface glycoprotein gp160; precursor inhibits 24725927
25738301
capsid incorporates 25422070
25464829
capsid downregulated by 23376165
24076421
24725927
HIV-1 virus replication inhibited by expression of human gene 25422070
2546482926387945
26387945
capsid interacts with 24663101
Vpu inhibits 24725927
Vpr interacts with 25463599
26387945
Envelope surface glycoprotein gp160; precursor modulates 25738301
capsid co-localizes with 25422070
Vpr upregulates 26116899
Nef downregulated by 23376165
24076421

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04662 B cell receptor signaling pathway - Homo sapiens (human)
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