Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0001394
UniProt IDO75874
Primary gene name(s)IDH1
Synonym gene name(s)PICD
Protein nameIsocitrate dehydrogenase [NADP] cytoplasmic
Protein functionunknown
Subcellular locationCytoplasm {ECO:0000269|PubMed:10521434}. Peroxisome {ECO:0000269|PubMed:10521434}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: O75874
Gene Ontology
(Biological Process)
Complete annatation
2-oxoglutarate metabolic process [GO:0006103];
female gonad development [GO:0008585];
glutathione metabolic process [GO:0006749];
glyoxylate cycle [GO:0006097];
isocitrate metabolic process [GO:0006102];
NADPH regeneration [GO:0006740];
regulation of phospholipid biosynthetic process [GO:0071071];
regulation of phospholipid catabolic process [GO:0060696];
response to oxidative stress [GO:0006979];
response to steroid hormone [GO:0048545];
tricarboxylic acid cycle [GO:0006099]
Gene Ontology
(Molecular Function)
Complete annatation
(R-2-hydroxyglutarate dehydrogenase activity [GO:0051990];
isocitrate dehydrogenase, NADP+ activity [GO:0004450];
magnesium ion binding [GO:0000287];
NAD binding [GO:0051287];
NADP binding [GO:0050661];
protein homodimerization activity [GO:0042803];
receptor binding [GO:0005102]
Gene Ontology
(Cellular Component)
Complete annatation
cytoplasm [GO:0005737];
cytosol [GO:0005829];
extracellular exosome [GO:0070062];
mitochondrion [GO:0005739];
peroxisomal matrix [GO:0005782];
peroxisome [GO:0005777]
Protein-protein interaction109643
Phylogenetic treeO75874
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-0.8562329757087680.01193701586681080.030334632126888
AZA vs. DISU0.2599179991400150.309562511917540.866242136589333
AZA vs. IL7-0.01311292164037210.9463510021710790.999311006273513
AZA vs. SAHA0.3157985894496040.1990752434196940.566502890178473
DISU vs. CD31.104431847275930.0029180033517060.0103277723699498
DISU vs. IL7-0.2822335226507260.2670536027089120.653756586689972
DISU vs. SAHA0.05726179696327010.8457907146077340.959460211193042
DMSO vs. AZA-0.02938511810015070.863298617366151
DMSO vs. CD30.8170010688597340.0137429391501090.0326248626373137
DMSO vs. DISU-0.2908340804400270.23809866583080.755240348151999
DMSO vs. IL70.02336223271958840.8980650260132590.978344433238176
DMSO vs. SAHA0.3384541455696760.154459591956290.474226761959934
HIV vs. Mock in Activation-0.08232726591466740.9014358710751140.999983755607037
HIV vs. Mock in Latency0.08183542078517870.6295935019066970.999834320637052
IL7 vs. CD30.8506589698847230.01052051078915330.031148233966786
SAHA vs. CD31.147642683110.001960522271781450.00636472870222888
SAHA vs. IL70.3259437592219660.1843484140046930.413460495864715
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) TRUE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.44375 0.00108419
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
1.06 1.133 1.474 1.534 1.215
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

Drugbank ID Drug Name Drug Status Pharmacological Action Drug Action
DB01727 Isocitric Acid experimental unknown unknown
DB03461 2&,39;-Monophosphoadenosine 5&,39;-Diphosphoribose experimental unknown unknown

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
1T09 X-ray 2.7Å A/B=1-414.
1T0L X-ray 2.4Å A/B/C/D=1-414.
3INM X-ray 2.1Å A/B/C=1-414.
3MAP X-ray 2.8Å A/B=1-414.
3MAR X-ray 3.4Å A/B=1-414.
3MAS X-ray 3.2Å A/B=1-414.
4I3K X-ray 3.3Å A/B=1-414.
4I3L X-ray 3.2Å A/B=1-414.
4KZO X-ray 2.2Å A/B/C=1-414.
4L03 X-ray 2.1Å A/B/C=1-414.
4L04 X-ray 2.8Å A/B/C/D/E/F=1-414.
4L06 X-ray 2.2Å A/B/C/D/E/F=1-414.
4UMX X-ray 1.8Å A/B=1-414.
4UMY X-ray 2.0Å A/B=1-414.
4XRX X-ray 3.2Å A/B=1-414.
4XS3 X-ray 3.2Å A/B=1-414.
5DE1 X-ray 2.2Å A/B=2-414.
5GIR X-ray 1.9Å C/D=126-137.
5K10 EM 3.8Å A/B=3-413.
5K11 EM 3.8Å A/B=3-413.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
HIV-1 virus replication enhanced by expression of human gene 18854154

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa00020 Citrate cycle (TCA cycle) - Homo sapiens (human)
hsa00480 Glutathione metabolism - Homo sapiens (human)
hsa01100 Metabolic pathways - Homo sapiens (human)
hsa01200 Carbon metabolism - Homo sapiens (human)
hsa01210 2-Oxocarboxylic acid metabolism - Homo sapiens (human)
hsa01230 Biosynthesis of amino acids - Homo sapiens (human)
hsa04146 Peroxisome - Homo sapiens (human)
hsa05230 Central carbon metabolism in cancer - Homo sapiens (human)