Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0001382
UniProt IDP61604
Primary gene name(s)HSPE1
Synonym gene name(s)unknown
Protein name10 kDa heat shock protein, mitochondrial
Protein functionEukaryotic CPN10 homolog which is essential for mitochondrial protein biogenesis, together with CPN60. Binds to CPN60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.
Subcellular locationMitochondrion matrix.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P61604
Gene Ontology
(Biological Process)
Complete annatation
activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919];
chaperone mediated protein folding requiring cofactor [GO:0051085];
osteoblast differentiation [GO:0001649];
protein folding [GO:0006457];
response to unfolded protein [GO:0006986]
Gene Ontology
(Molecular Function)
Complete annatation
ATP binding [GO:0005524];
chaperone binding [GO:0051087];
metal ion binding [GO:0046872];
poly(A RNA binding [GO:0044822];
unfolded protein binding [GO:0051082]
Gene Ontology
(Cellular Component)
Complete annatation
extracellular exosome [GO:0070062];
membrane [GO:0016020];
mitochondrial matrix [GO:0005759];
mitochondrion [GO:0005739]
Protein-protein interaction109568
Phylogenetic treeP61604
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
      unknown
Brass et al., Science, 2008
      unknown
Smith et al., J. Immunol, 2010
      unknown
Interferon-stimulated
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model


DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD32.661544171194642.02060590481778e-146.35794826668344e-13
AZA vs. DISU-0.1297073949459060.6085827726527830.956299042527681
AZA vs. IL70.6565938422444230.0006788678313274230.0588617707323683
AZA vs. SAHA-0.1986596136581670.4169401538291420.771728374118428
DISU vs. CD3-2.804198792727964.99045249569008e-131.89486349924514e-11
DISU vs. IL70.7773307476363890.002148068535138380.0445036971370772
DISU vs. SAHA-0.06799296264161190.8155506613859690.952584403362323
DMSO vs. AZA-0.0774416562201610.6448505283505591
DMSO vs. CD3-2.748631136221637.7715611723761e-162.63097908004148e-14
DMSO vs. DISU0.05076794815461030.8352947874367440.981844704166786
DMSO vs. IL70.7409883075011934.19435321936668e-050.00638685603858107
DMSO vs. SAHA-0.1292443954006230.5843841151525480.857201504507045
HIV vs. Mock in Activation-0.2524017544280120.6849392812834370.999983755607037
HIV vs. Mock in Latency-0.2929248715862790.09419560152384880.999834320637052
IL7 vs. CD3-1.996169692630612.13936723891806e-093.65194591078277e-08
SAHA vs. CD3-2.885341643227243.25295346215171e-141.3213479427123e-12
SAHA vs. IL7-0.8585758092462190.0004664554496890410.00652864387057808
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change -2.185175546
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
1.7 1.57E-05 1.2 0.056062891 1.1 0.341244062
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) FALSE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.531586 0.157356
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
1.111 0.902 0.799 0.844 0.992
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
4PJ1 X-ray 3.1Å 1/2/O/P/Q/R/S/T/U/V/W/X/Y/Z=1-102.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
integrase interacts with 11689615
Tat upregulates 23364796

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
not found
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