Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0001362
UniProt IDQ9NSB8
Primary gene name(s)HOMER2
Synonym gene name(s)unknown
Protein nameHomer protein homolog 2
Protein functionPostsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses, PubMed:9808459. Required for normal hearing, PubMed:25816005. {ECO:0000269|PubMed:25816005, ECO:0000269|PubMed:9808459}.
Subcellular locationCytoplasm {ECO:0000269|PubMed:25816005}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell junction, synapse. Cell projection, stereocilium {ECO:0000250|UniProtKB:Q9QWW1}. Note=Postsynaptic density of neuronal cells. The stabilization and clustering of the metabotropic glutamate receptors appears to be mediated by isoform 1 and isoform 2 at the cell surface.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q9NSB8
Gene Ontology
(Biological Process)
Complete annatation
behavioral response to cocaine [GO:0048148];
calcium-mediated signaling using intracellular calcium source [GO:0035584];
chemical homeostasis within a tissue [GO:0048875];
G-protein coupled glutamate receptor signaling pathway [GO:0007216];
regulation of G-protein coupled receptor protein signaling pathway [GO:0008277];
sensory perception of sound [GO:0007605]
Gene Ontology
(Molecular Function)
Complete annatation
G-protein coupled glutamate receptor binding [GO:0035256]
Gene Ontology
(Cellular Component)
Complete annatation
cell junction [GO:0030054];
cytoplasm [GO:0005737];
dendrite [GO:0030425];
neuronal cell body [GO:0043025];
nucleolus [GO:0005730];
nucleus [GO:0005634];
plasma membrane [GO:0005886];
postsynaptic density [GO:0014069];
postsynaptic membrane [GO:0045211];
stereocilium tip [GO:0032426]
Protein-protein interaction114844
Phylogenetic treeQ9NSB8
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD32.504522802427354.69513317113979e-131.20144392454022e-11
AZA vs. DISU-0.4576835702641950.07465157814195160.586450572749334
AZA vs. IL70.3638383508233860.0634783093704030.723909865561374
AZA vs. SAHA0.1708602252213240.4888594348707570.814028989630984
DISU vs. CD3-2.972984455156592.83106871279415e-141.31714598076108e-12
DISU vs. IL70.8116966299082820.001520094433816180.0362098957137686
DISU vs. SAHA0.6302101364569550.03278778116307320.217780806482449
DMSO vs. AZA-0.110953321673360.6267861776625341
DMSO vs. CD3-2.620640246785638.38218383591993e-142.14757822258731e-12
DMSO vs. DISU0.3467500991368840.19810027077850.714476110271018
DMSO vs. IL70.4810303978922630.01542083948077180.259162937762134
DMSO vs. SAHA0.2740822595406490.2627316457644590.611998243170967
HIV vs. Mock in Activation0.7305242961242220.2426860875721120.999983755607037
HIV vs. Mock in Latency0.3222585925004680.05877409338857980.946539192029328
IL7 vs. CD3-2.135352395623681.97463267959108e-103.98442280849751e-09
SAHA vs. CD3-2.357461523284612.13744355548329e-104.20078331094723e-09
SAHA vs. IL7-0.195192345587490.4283063607423280.670087190641396
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) TRUE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.102794 0.728841
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04068 FoxO signaling pathway - Homo sapiens (human)
hsa04724 Glutamatergic synapse - Homo sapiens (human)