Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0001359
UniProt IDO43390
Primary gene name(s)HNRNPR
Synonym gene name(s)HNRPR
Protein nameHeterogeneous nuclear ribonucleoprotein R
Protein functionComponent of ribonucleosomes, which are complexes of at least 20 other different heterogenious nuclear ribonucleoproteins, hnRNP. hnRNP play an important role in processing of precursor mRNA in the nucleus.
Subcellular locationNucleus {ECO:0000250|UniProtKB:Q7TMK9}. Microsome {ECO:0000250|UniProtKB:Q7TMK9}. Nucleus, nucleoplasm {ECO:0000269|PubMed:17289661}. Cytoplasm {ECO:0000269|PubMed:17289661}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. The tyrosine phosphorylated form bound to RNA is found in microsomes, By similarity. {ECO:0000250|UniProtKB:Q7TMK9, ECO:0000269|PubMed:17289661}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: O43390
Gene Ontology
(Biological Process)
Complete annatation
circadian rhythm [GO:0007623];
gene expression [GO:0010467];
mRNA destabilization [GO:0061157];
mRNA processing [GO:0006397];
mRNA splicing, via spliceosome [GO:0000398];
negative regulation of catalytic activity [GO:0043086];
positive regulation of mRNA catabolic process [GO:0061014]
Gene Ontology
(Molecular Function)
Complete annatation
mRNA 3'-UTR binding [GO:0003730];
nucleotide binding [GO:0000166];
poly(A RNA binding [GO:0044822];
RNA binding [GO:0003723]
Gene Ontology
(Cellular Component)
Complete annatation
axon terminus [GO:0043679];
catalytic step 2 spliceosome [GO:0071013];
dendrite [GO:0030425];
endoplasmic reticulum [GO:0005783];
growth cone [GO:0030426];
intracellular ribonucleoprotein complex [GO:0030529];
nucleoplasm [GO:0005654];
spliceosomal complex [GO:0005681]
Protein-protein interaction115530
Phylogenetic treeO43390
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
      Negatively associated
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD31.089675929744160.0009787147646367340.00356739756532161
AZA vs. DISU-0.1269707172020570.6150521417420010.957895177103442
AZA vs. IL70.3340854292754090.0817282472381460.791194521914306
AZA vs. SAHA-0.3073875961304850.2072035512741740.576154631318058
DISU vs. CD3-1.228865932546290.0008133278825254160.00346232829742675
DISU vs. IL70.4519908890375910.0727971884881290.35851604588649
DISU vs. SAHA-0.1794805924872440.5374629123331510.844815079928753
DMSO vs. AZA-0.0134176923007550.9359598423233581
DMSO vs. CD3-1.113043084532850.0005684840833682920.00209036190284192
DMSO vs. DISU0.1121306197875720.6452281586586150.948272708307521
DMSO vs. IL70.3544833684741810.04828400311061910.438223065118921
DMSO vs. SAHA-0.3014392989714390.2005373484877990.53921469742366
HIV vs. Mock in Activation-0.05159742343629890.9338455527342580.999983755607037
HIV vs. Mock in Latency0.06955292745127710.6726605324279490.999834320637052
IL7 vs. CD3-0.7474823817389830.02040795204130160.0531276444073471
SAHA vs. CD3-1.422058259855147.62992685467978e-050.000377612471921262
SAHA vs. IL7-0.6450578180709090.00819886925388280.0547228468136103
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) FALSE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.30402 0.0243025
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
1.016 1.004 0.91 0.807 0.917
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
2DK2 NMR - A=333-416.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Rev interacts with 22174317
Envelope surface glycoprotein gp120 complexes with 23125841
Rev binds 19808671
Gag-Pol complexes with 23125841
Pr55(Gag) complexes with 23125841
Nef complexes with 23125841

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
not found