Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0001354
UniProt IDP31943
Primary gene name(s)HNRNPH1
Synonym gene name(s)HNRPH, HNRPH1
Protein nameHeterogeneous nuclear ribonucleoprotein H
Protein functionThis protein is a component of the heterogeneous nuclear ribonucleoprotein, hnRNP complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor, IR pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG. {ECO:0000269|PubMed:11003644, ECO:0000269|PubMed:16946708}.
Subcellular locationNucleus, nucleoplasm.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P31943
Gene Ontology
(Biological Process)
Complete annatation
fibroblast growth factor receptor signaling pathway [GO:0008543];
gene expression [GO:0010467];
mRNA splicing, via spliceosome [GO:0000398];
regulation of RNA splicing [GO:0043484];
RNA processing [GO:0006396]
Gene Ontology
(Molecular Function)
Complete annatation
nucleotide binding [GO:0000166];
poly(A RNA binding [GO:0044822];
poly(U RNA binding [GO:0008266];
RNA binding [GO:0003723]
Gene Ontology
(Cellular Component)
Complete annatation
catalytic step 2 spliceosome [GO:0071013];
cytoplasm [GO:0005737];
membrane [GO:0016020];
nucleoplasm [GO:0005654];
nucleus [GO:0005634]
Protein-protein interaction109428
Phylogenetic treeP31943
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD30.337864208390970.3015142964312280.419963356049483
AZA vs. DISU0.1706400017544050.4991882882055970.934754900374469
AZA vs. IL70.1142205003272170.5510244901099180.999311006273513
AZA vs. SAHA0.09982084511184920.6814551761682530.907389764583217
DISU vs. CD3-0.1816256362767510.6159278350120490.724332671631427
DISU vs. IL7-0.06511336738226780.7954581914448750.954423799099071
DISU vs. SAHA-0.06944165747504120.8112846946201510.951282735025405
DMSO vs. AZA0.1015731592598140.5420871457326891
DMSO vs. CD3-0.2472539630359130.4385547655807370.551350041181157
DMSO vs. DISU-0.07057412798831760.7719201082989610.97150326349898
DMSO vs. IL70.01982161144781410.9118744157130690.981734048116649
DMSO vs. SAHA-0.008948421043012990.9696236085434060.993292390076406
HIV vs. Mock in Activation0.2041793730920490.7424774383389960.999983755607037
HIV vs. Mock in Latency-0.05709604411950420.7279133224832360.999834320637052
IL7 vs. CD3-0.2160565626217470.500604529752610.630798535107933
SAHA vs. CD3-0.2631028973928090.4556959293624870.568018002935706
SAHA vs. IL7-0.01870595698624040.9385928122201410.976524942082016
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
-1.4 0.103977578 -1.4 0.061272334 -2.2 0.026253331
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) FALSE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.499481 0.000305467
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
0.993 1.007 0.92 0.876 1.042
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
2LXU NMR - A=7-111.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Rev interacts with 22174317
Envelope surface glycoprotein gp120 complexes with 23125841
Gag-Pol complexes with 23125841
Vpr regulated by 25169827
Vif regulated by 23255806
Pr55(Gag) complexes with 23125841
HIV-1 virus replication enhanced by expression of human gene 18854154
Nef complexes with 23125841

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
not found