Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0001346
UniProt IDO75330
Primary gene name(s)HMMR
Synonym gene name(s)IHABP, RHAMM
Protein nameHyaluronan mediated motility receptor
Protein functionInvolved in cell motility. When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including PTK2/FAK1 occurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular-regulated kinase, ERK activity.
Subcellular locationCell surface. Cytoplasm {ECO:0000250}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: O75330
Gene Ontology
(Biological Process)
Complete annatation
G2/M transition of mitotic cell cycle [GO:0000086];
hyaluronan catabolic process [GO:0030214]
Gene Ontology
(Molecular Function)
Complete annatation
hyaluronic acid binding [GO:0005540]
Gene Ontology
(Cellular Component)
Complete annatation
cell surface [GO:0009986];
cytosol [GO:0005829];
membrane [GO:0016020];
plasma membrane [GO:0005886]
Protein-protein interaction109404
Phylogenetic treeO75330
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD30.4199508958798590.6909229758349970.778760925200799
AZA vs. DISU-0.1460706533579790.8248823224279610.985049206074554
AZA vs. IL70.05496166794514220.942028430940660.999311006273513
AZA vs. SAHA-0.6008463597984870.3747896986617160.740540033769393
DISU vs. CD3-0.5775291619773240.5697363023992550.686352346729689
DISU vs. IL70.1918295613129970.7494406224936720.939560944033259
DISU vs. SAHA-0.4565581169902360.3236584087176450.706628404720212
DMSO vs. AZA-0.2784069797580560.6871368101739041
DMSO vs. CD3-0.7128722519717260.4776701723313840.587868731817033
DMSO vs. DISU-0.1354953987270910.7836598838762990.97263667023685
DMSO vs. IL70.341138719301380.591635976796060.909845858619163
DMSO vs. SAHA-0.3320318601232060.5202991472415090.824102204119421
HIV vs. Mock in Activation-0.5757901588489320.7602247329314920.999983755607037
HIV vs. Mock in Latency0.2913086815139980.5671657655780610.999834320637052
IL7 vs. CD3-0.3529317845368090.7325516720833980.819972623890766
SAHA vs. CD3-1.049130943268710.3097090325656790.423531317673755
SAHA vs. IL7-0.6621306800626870.2857754657040170.533141011141381
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
2.9 0.001991891 1.7 0.068889696 1.9 0.090714614
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) FALSE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.538011 0.000305467
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
0.025 0.006

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
1.018 1.941 4.081 4.072 1.435
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
207165_at 4.39 No upregulated in CD8+ cells
209709_s_at 2.26 No upregulated in CD8+ cells

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

Drugbank ID Drug Name Drug Status Pharmacological Action Drug Action
DB08818 Hyaluronic acid approved, vet_approved yes unknown

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04512 ECM-receptor interaction - Homo sapiens (human)