Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0001345
UniProt IDP05114
Primary gene name(s)HMGN1
Synonym gene name(s)HMG14
Protein nameNon-histone chromosomal protein HMG-14
Protein functionBinds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation. Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2, By similarity. {ECO:0000250}.
Subcellular locationNucleus. Cytoplasm. Note=Cytoplasmic enrichment upon phosphorylation. The RNA edited version localizes to the nucleus.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P05114
Gene Ontology
(Biological Process)
Complete annatation
chromatin organization [GO:0006325];
positive regulation of DNA-templated transcription, elongation [GO:0032786];
positive regulation of NAD+ ADP-ribosyltransferase activity [GO:1901666];
post-embryonic camera-type eye morphogenesis [GO:0048597];
pyrimidine dimer repair by nucleotide-excision repair [GO:0000720];
regulation of development, heterochronic [GO:0040034];
regulation of epithelial cell proliferation [GO:0050678];
regulation of transcription from RNA polymerase II promoter [GO:0006357];
response to UV-B [GO:0010224];
response to UV-C [GO:0010225];
transcription-coupled nucleotide-excision repair [GO:0006283]
Gene Ontology
(Molecular Function)
Complete annatation
DNA binding [GO:0003677]
Gene Ontology
(Cellular Component)
Complete annatation
chromatin [GO:0000785];
cytoplasm [GO:0005737];
nucleoplasm [GO:0005654];
nucleus [GO:0005634]
Protein-protein interaction109393
Phylogenetic treeP05114
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD30.3958042524080280.2270261173569780.336615666645988
AZA vs. DISU-0.3250919405448590.1983350921658080.788134825409557
AZA vs. IL70.07847500763832540.6822958565343180.999311006273513
AZA vs. SAHA0.3221238133144710.1874381980084150.552383850787653
DISU vs. CD3-0.7340731882708360.04360088930677690.096596091330152
DISU vs. IL70.3949487331999150.1167604987592270.446585359886976
DISU vs. SAHA0.6480149486149860.02716370533556560.194759373507283
DMSO vs. AZA-0.05961646845874730.7210550696584031
DMSO vs. CD3-0.4671782276677440.1447615815295170.2306189968282
DMSO vs. DISU0.2635759816823510.2795988390194230.796010394098976
DMSO vs. IL70.1453321577027430.4177462880496990.852467385552928
DMSO vs. SAHA0.3743661308994820.112720583899490.399007907893253
HIV vs. Mock in Activation-0.2507966302580570.6866013557075210.999983755607037
HIV vs. Mock in Latency-0.1236985445691040.4517177373078840.999834320637052
IL7 vs. CD3-0.3083094445475830.3369528375914090.475080479388588
SAHA vs. CD3-0.0994710829015190.7795920837577390.842787137893051
SAHA vs. IL70.2395071745978790.3263206041744530.576092824411401
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) FALSE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.0151737 0.943104
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
0.951 1.121 1.382 1.251 1.058
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Tat upregulates 25472883

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa05168 Herpes simplex infection - Homo sapiens (human)