Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0001332
UniProt IDP28067
Primary gene name(s)HLA-DMA
Synonym gene name(s)DMA, RING6
Protein nameHLA class II histocompatibility antigen, DM alpha chain
Protein functionPlays a critical role in catalyzing the release of class II-associated invariant chain peptide, CLIP from newly synthesized MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. {ECO:0000269|PubMed:16547258, ECO:0000269|PubMed:8849454, ECO:0000269|PubMed:9768757}.
Subcellular locationLate endosome membrane;
Single-pass type I membrane protein. Lysosome membrane;
Single-pass type I membrane protein. Note=Localizes to late endocytic compartment. Associates with lysosome membranes.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P28067
Gene Ontology
(Biological Process)
Complete annatation
antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886];
immune response [GO:0006955];
peptide antigen assembly with MHC class II protein complex [GO:0002503]
Gene Ontology
(Molecular Function)
Complete annatation
MHC class II protein complex binding [GO:0023026]
Gene Ontology
(Cellular Component)
Complete annatation
cell surface [GO:0009986];
extracellular exosome [GO:0070062];
integral component of membrane [GO:0016021];
late endosome membrane [GO:0031902];
lysosomal membrane [GO:0005765];
membrane [GO:0016020];
MHC class II protein complex [GO:0042613]
Protein-protein interactionunknown
Phylogenetic treeP28067
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-0.9109583012616840.006394458830242370.0178377352377222
AZA vs. DISU-0.2094893692213470.4142886563367910.910230653368199
AZA vs. IL7-0.1639350860068520.4064658126639820.999311006273513
AZA vs. SAHA0.6732423367232110.006568070697143270.0739410737033142
DISU vs. CD30.689596247973030.06169779914588680.127857110850302
DISU vs. IL70.03484097340401060.8918848313005760.98029047000329
DISU vs. SAHA0.8857310069936060.002736140351598750.0424679415437124
DMSO vs. AZA0.0668492855478710.6989799390449841
DMSO vs. CD30.9664961382234890.003109712940766340.00918224724669638
DMSO vs. DISU0.2743986014439090.2671213105288560.785150483865518
DMSO vs. IL7-0.2239785409495580.2258757341710760.733131484020963
DMSO vs. SAHA0.601745499755830.01178418879708120.100247628140157
HIV vs. Mock in Activation-0.02466961034298020.9687242408340340.999983755607037
HIV vs. Mock in Latency0.1206230930094010.4736523132528160.999834320637052
IL7 vs. CD30.7518869763681590.02117281847579910.0547312455643492
SAHA vs. CD31.561814802423771.8457181816367e-050.000107518256657383
SAHA vs. IL70.8360504197596240.0007592538638713230.00948218122949157
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) TRUE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.802355 0.000305467
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
217478_s_at 1.5 No upregulated in CD8+ cells

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
1HDM X-ray 2.5Å A=27-230.
2BC4 X-ray 2.2Å A/C=27-229.
4FQX X-ray 2.6Å C=27-225.
4GBX X-ray 3.0Å C=27-225.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Pr55(Gag) upregulates 18945465
Envelope transmembrane glycoprotein gp41 incorporates 10729169
Envelope surface glycoprotein gp120 interacts with 1869305
Envelope surface glycoprotein gp160; precursor associates with 3489470
Nef inhibits 11593029
Nef downregulates 12970439
Pr55(Gag) regulated by 22860026
Tat downregulates 10661406
Vpu modulates 17959659
Envelope transmembrane glycoprotein gp41 upregulates 8084338
Envelope surface glycoprotein gp120 inhibits 2543930

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
not found