Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0001297
UniProt IDP01889
Primary gene name(s)HLA-B
Synonym gene name(s)HLAB
Protein nameHLA class I histocompatibility antigen, B-7 alpha chain
Protein functionInvolved in the presentation of foreign antigens to the immune system.
Subcellular locationMembrane;
Single-pass type I membrane protein.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P01889
Gene Ontology
(Biological Process)
Complete annatation
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [GO:0002479];
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent [GO:0002480];
antigen processing and presentation of peptide antigen via MHC class I [GO:0002474];
immune response [GO:0006955];
interferon-gamma-mediated signaling pathway [GO:0060333];
protection from natural killer cell mediated cytotoxicity [GO:0042270];
regulation of dendritic cell differentiation [GO:2001198];
regulation of immune response [GO:0050776];
regulation of interleukin-12 production [GO:0032655];
regulation of interleukin-6 production [GO:0032675];
regulation of T cell anergy [GO:0002667];
type I interferon signaling pathway [GO:0060337];
viral process [GO:0016032]
Gene Ontology
(Molecular Function)
Complete annatation
peptide antigen binding [GO:0042605];
receptor binding [GO:0005102]
Gene Ontology
(Cellular Component)
Complete annatation
cell surface [GO:0009986];
early endosome membrane [GO:0031901];
endoplasmic reticulum [GO:0005783];
ER to Golgi transport vesicle membrane [GO:0012507];
extracellular exosome [GO:0070062];
Golgi apparatus [GO:0005794];
Golgi membrane [GO:0000139];
integral component of lumenal side of endoplasmic reticulum membrane [GO:0071556];
integral component of plasma membrane [GO:0005887];
membrane [GO:0016020];
MHC class I protein complex [GO:0042612];
phagocytic vesicle membrane [GO:0030670];
plasma membrane [GO:0005886]
Protein-protein interaction109351
Phylogenetic treeP01889
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
      unknown
Brass et al., Science, 2008
      unknown
Smith et al., J. Immunol, 2010
      unknown
Interferon-stimulated
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: 5.613019222; Folds changes 16h: 3.97970088; Tested: untested;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model


DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD30.1997219817858690.5422252374305840.655208753191194
AZA vs. DISU-0.4092019400604680.105180612524790.653313462609335
AZA vs. IL7-0.0927525915870210.6279677274863150.999311006273513
AZA vs. SAHA-0.215974911111630.375184235343340.740888595399118
DISU vs. CD3-0.6199564450129150.08861675315689130.169583462877616
DISU vs. IL70.3069968186120440.2220675273149570.604149891029194
DISU vs. SAHA0.1949070671891750.5031603892435350.826933029981256
DMSO vs. AZA-0.0006702815598037980.9967885480591461
DMSO vs. CD3-0.215001443329990.5024342870385480.610515610117416
DMSO vs. DISU0.4057610499942120.09582996118376220.561569786929451
DMSO vs. IL7-0.08424686628504140.6377722993717960.921461718990524
DMSO vs. SAHA-0.2200871747607510.3493611011788410.699868428879596
HIV vs. Mock in Activation-0.01182086354262140.9848253527454460.999983755607037
HIV vs. Mock in Latency-0.005531456239493960.9731083400003830.999834320637052
IL7 vs. CD3-0.2858148237201150.3753891836143050.512521844621234
SAHA vs. CD3-0.4392814444807280.2172504019325190.322177086904454
SAHA vs. IL7-0.1261171210024270.6034796454903810.799190640987691
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) TRUE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -0.0305724 0.93852
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
3VCL X-ray 1.7Å A=25-299.
4U1H X-ray 1.5Å A=25-300.
4U1K X-ray 2.0Å A/D=25-300.
5EO0 X-ray 1.7Å A=25-299.
5EO1 X-ray 1.8Å A=25-299.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Envelope surface glycoprotein gp120 interacts with 7539755
9263011
12427289
Tat upregulates 11751963
14595379
Pr55(Gag) interacts with 17251285
19242411
2578198617878955
18434400
21482733
Nef complexes with 22705789
22767237
Asp inhibited by 20065064
2570111225589651
Vpr interacts with 18434400
19275586
Nef modulates 11396948
14557639
22613796
234900519971776
12502873
15078178
17170457
18005690
Envelope surface glycoprotein gp160; precursor interacts with 1316930
10799863
Nef binds 9582271
10366557
10982373
11463741
12414957
12836198
14965316
15078178
18057255
18296443
18653452
19149577
22301137
22705789
22767237
23170180
23202450
matrix interacts with 23061377
Nef downregulates 10403641
23170180
2320245010684310
15078178
22301137
22705789
2276723710707087
18005690
1914957711289809
12526811
18438604
19149577
2070258211438519
11500821
11578695
11602047
12097566
1561122512482663
1288419214557639
1707729615194762
1815526415878340
16365153
18005690
18005690
18296443
23170180
2320245022301137
22537596
22553319
22826228
23289738
24041011
2519365624965469
8612235
12734410
15638726
16091223
16272310
17581864
17586321
17632197
17632570
18005680
18005690
18155264
18438604
18473783
18541215
18653452
18725938
18808677
19091857
19149577
19449444
19555986
19643141
19770068
20012528
20380698
20594957
20702582
21068258
21165790
21209113
21482738
21543478
21762823
21861776
21922073
21994772
22103831
22103833
22103834
22175768
22301137
22301152
22537596
22553319
22613796
22651890
22826228
22844345
22980333
23170180
23202450
23289738
23490051
23847689
23853598
23986795
24023945
24041011
24158818
24400003
24495362
24748005
24904546
24965469
25193656
25275127
258275319052838
9586638
18438604
18808677
19149577
19847956
22705789
22767237
23170180
23202450
236781829123874
Pr55(Gag) enhances 18097038
Tat downregulates 17604883
7621073
8493575
9751712
9840288
Nef interacts with 17878955
18057255
23061377
24380790
Vpu regulated by 22503975
Nef degrades 18725938
capsid interacts with 23061377
23079801
23087682
Pr55(Gag) upregulates 21778700
Nef co-localizes with 15854903
Rev interacts with 18434400
Envelope surface glycoprotein gp120 complexes with 2789433
8671651
8877415
9120272
10546855
11932387
Pr55(Gag) associates with 22761389
22883001
22896606
22933291
24339913
24501417
24740510
Vpu downregulates 9104816
18672082
20012522
24400003
25275127
25620704
Asp binds 25809376
Envelope transmembrane glycoprotein gp41 upregulates 7913356
93732178084338
8084338

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04144 Endocytosis - Homo sapiens (human)
hsa04145 Phagosome - Homo sapiens (human)
hsa04514 Cell adhesion molecules (CAMs) - Homo sapiens (human)
hsa04612 Antigen processing and presentation - Homo sapiens (human)
hsa04650 Natural killer cell mediated cytotoxicity - Homo sapiens (human)
hsa04940 Type I diabetes mellitus - Homo sapiens (human)
hsa05166 HTLV-I infection - Homo sapiens (human)
hsa05168 Herpes simplex infection - Homo sapiens (human)
hsa05169 Epstein-Barr virus infection - Homo sapiens (human)
hsa05203 Viral carcinogenesis - Homo sapiens (human)
hsa05320 Autoimmune thyroid disease - Homo sapiens (human)
hsa05330 Allograft rejection - Homo sapiens (human)
hsa05332 Graft-versus-host disease - Homo sapiens (human)
hsa05416 Viral myocarditis - Homo sapiens (human)
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