Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0001273
UniProt IDQ9ULI3
Primary gene name(s)HEG1
Synonym gene name(s)KIAA1237
Protein nameProtein HEG homolog 1
Protein functionReceptor component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity May act through the stabilization of endothelial cell junctions. {ECO:0000250}.
Subcellular locationIsoform 1: Cell membrane {ECO:0000305};
Single-pass type I membrane protein {ECO:0000305}. Cell junction {ECO:0000250}.;
SUBCELLULAR LOCATION: Isoform 2: Secreted {ECO:0000305}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q9ULI3
Gene Ontology
(Biological Process)
Complete annatation
cardiac atrium morphogenesis [GO:0003209];
cardiac muscle tissue growth [GO:0055017];
cell-cell junction assembly [GO:0007043];
endothelial cell morphogenesis [GO:0001886];
in utero embryonic development [GO:0001701];
lung development [GO:0030324];
lymph circulation [GO:0003017];
lymph vessel development [GO:0001945];
multicellular organism growth [GO:0035264];
pericardium development [GO:0060039];
positive regulation of fibroblast growth factor production [GO:0090271];
post-embryonic development [GO:0009791];
regulation of body fluid levels [GO:0050878];
vasculogenesis [GO:0001570];
venous blood vessel morphogenesis [GO:0048845];
ventricular septum development [GO:0003281];
ventricular trabecula myocardium morphogenesis [GO:0003222]
Gene Ontology
(Molecular Function)
Complete annatation
calcium ion binding [GO:0005509]
Gene Ontology
(Cellular Component)
Complete annatation
cell-cell junction [GO:0005911];
external side of plasma membrane [GO:0009897];
extracellular region [GO:0005576];
integral component of membrane [GO:0016021]
Protein-protein interaction121560
Phylogenetic treeQ9ULI3
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD30.4828213332596390.1411048119160010.231342513346891
AZA vs. DISU0.02508793006831750.9209332628325910.994889252656529
AZA vs. IL70.7717201082112166.46479226149577e-050.0114639780891207
AZA vs. SAHA-0.03153376961271450.8971005128340580.977228871980098
DISU vs. CD3-0.4700251398195360.1954305186102410.313362369697987
DISU vs. IL70.7372760149646390.003560986134878210.0609328785281373
DISU vs. SAHA-0.05411194194866460.8525427903571160.960232245593492
DMSO vs. AZA0.04486233821529790.8049916817525621
DMSO vs. CD3-0.446169570383090.1633971592431840.253988278429573
DMSO vs. DISU0.01887439417837520.9382911269318270.992151509981231
DMSO vs. IL70.7337254916972834.80968700468098e-050.00708543403827254
DMSO vs. SAHA-0.08288249360174810.7250707086128850.919204979591309
HIV vs. Mock in Activation0.8028595736148410.2003554289472030.999983755607037
HIV vs. Mock in Latency0.06788567435550790.7739273483341580.999834320637052
IL7 vs. CD30.2947031924314930.358652246019370.495900967172343
SAHA vs. CD3-0.5376578954264690.1292061007152990.213947471462428
SAHA vs. IL7-0.8048554290248080.001013791926962490.0117753843354905
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) TRUE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.699029 0.000305467
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
3U7D X-ray 2.4Å B/D=1356-1381.
4HDQ X-ray 1.9Å C=1356-1381.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
not found