Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0001262
UniProt IDQ8WUI4
Primary gene name(s)HDAC7
Synonym gene name(s)HDAC7A
Protein nameHistone deacetylase 7
Protein functionResponsible for the deacetylation of lysine residues on the N-terminal part of the core histones, H2A, H2B, H3 and H4. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors, By similarity. May be involved in Epstein-Barr virus, EBV latency, possibly by repressing the viral BZLF1 gene. Positively regulates the transcriptional repressor activity of FOXP3, PubMed:17360565. {ECO:0000250|UniProtKB:Q8C2B3, ECO:0000269|PubMed:12239305, ECO:0000269|PubMed:17360565}.
Subcellular locationNucleus. Cytoplasm. Note=In the nucleus, it associates with distinct subnuclear dot-like structures. Shuttles between the nucleus and the cytoplasm. Treatment with EDN1 results in shuttling from the nucleus to the perinuclear region. The export to cytoplasm depends on the interaction with the 14-3-3 protein YWHAE and is due to its phosphorylation.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q8WUI4
Gene Ontology
(Biological Process)
Complete annatation
cell-cell junction assembly [GO:0007043];
negative regulation of interleukin-2 production [GO:0032703];
negative regulation of NIK/NF-kappaB signaling [GO:1901223];
negative regulation of osteoblast differentiation [GO:0045668];
negative regulation of transcription from RNA polymerase II promoter [GO:0000122];
positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050];
protein sumoylation [GO:0016925];
transcription, DNA-templated [GO:0006351];
vasculogenesis [GO:0001570]
Gene Ontology
(Molecular Function)
Complete annatation
14-3-3 protein binding [GO:0071889];
activating transcription factor binding [GO:0033613];
chromatin binding [GO:0003682];
metal ion binding [GO:0046872];
NAD-dependent histone deacetylase activity, H3-K14 specific [GO:0032041];
protein kinase binding [GO:0019901];
protein kinase C binding [GO:0005080];
repressing transcription factor binding [GO:0070491];
SUMO transferase activity [GO:0019789];
transcription corepressor activity [GO:0003714]
Gene Ontology
(Cellular Component)
Complete annatation
cytoplasm [GO:0005737];
histone deacetylase complex [GO:0000118];
nucleoplasm [GO:0005654];
nucleus [GO:0005634]
Protein-protein interaction119613
Phylogenetic treeQ8WUI4
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD30.7045130182676230.03200811369664650.0687510744813817
AZA vs. DISU0.03054921368243190.9038896249427260.993937521279788
AZA vs. IL7-0.3095489489913750.1076595040292610.855877773288426
AZA vs. SAHA-0.01524202082974610.9503101680064870.98963425909785
DISU vs. CD3-0.6865929576238410.05945619418588250.124156115133269
DISU vs. IL7-0.3493919726369420.1657861443579530.528124071822841
DISU vs. SAHA-0.04333547530034930.8817054005823850.969515693285942
DMSO vs. AZA0.06507051027310360.6975100729656951
DMSO vs. CD3-0.6539360075108730.041410111210090.0819552450578042
DMSO vs. DISU0.03193983635387290.8958320681657870.988283279918411
DMSO vs. IL7-0.3668539888849370.04153158782572790.412907162036172
DMSO vs. SAHA-0.08487856771603610.7193766962030160.916764574572562
HIV vs. Mock in Activation-0.0397158228230190.9490658462840690.999983755607037
HIV vs. Mock in Latency-0.07520091579652090.6480837242922960.999834320637052
IL7 vs. CD3-1.007898149363020.00187487238006290.00730608877577251
SAHA vs. CD3-0.7433704932798670.03691024455398810.0772230161639039
SAHA vs. IL70.2913431613632560.2324555777491150.472963466822774
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) FALSE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -0.23816 0.115594
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
0.921 1.182 1.018 1.189 1.101
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

Drugbank ID Drug Name Drug Status Pharmacological Action Drug Action
DB04297 7-[4-(Dimethylamino)Phenyl]-N-Hydroxy-4,6-Dimethyl-7-Oxo-2,4-Heptadienamide experimental unknown unknown
DB05015 Belinostat approved, investigational yes inhibitor
DB06603 Panobinostat approved, investigational yes inhibitor

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
3C0Y X-ray 2.1Å A/B/C=482-903.
3C0Z X-ray 2.1Å A/B/C=482-903.
3C10 X-ray 2.0Å A/B/C=482-903.
3ZNR X-ray 2.4Å A/B/C=482-903.
3ZNS X-ray 2.4Å A/B/C=482-903.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
matrix downregulates 26469385

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa05034 Alcoholism - Homo sapiens (human)
hsa05203 Viral carcinogenesis - Homo sapiens (human)