Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0001209
UniProt IDQ9Y5Y4
Primary gene name(s)PTGDR2
Synonym gene name(s)CRTH2, DL1R, GPR44
Protein nameProstaglandin D2 receptor 2
Protein functionReceptor for prostaglandin D2, PGD2. Coupled to the G(i-protein. Receptor activation may result in pertussis toxin-sensitive decreases in cAMP levels and Ca(2+ mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses. {ECO:0000269|PubMed:11208866, ECO:0000269|PubMed:11535533, ECO:0000269|PubMed:17196174}.
Subcellular locationCell membrane {ECO:0000305};
Multi-pass membrane protein {ECO:0000305}. Note=Internalized receptors colocalized with RAB11A. {ECO:0000269|PubMed:17207480}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q9Y5Y4
Gene Ontology
(Biological Process)
Complete annatation
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway [GO:0007193];
calcium-mediated signaling [GO:0019722];
chemical synaptic transmission [GO:0007268];
chemotaxis [GO:0006935];
G-protein coupled receptor signaling pathway [GO:0007186];
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187];
immune response [GO:0006955];
negative regulation of male germ cell proliferation [GO:2000255];
neuropeptide signaling pathway [GO:0007218];
positive regulation of G-protein coupled receptor protein signaling pathway [GO:0045745]
Gene Ontology
(Molecular Function)
Complete annatation
G-protein coupled receptor activity [GO:0004930];
neuropeptide binding [GO:0042923];
prostaglandin D receptor activity [GO:0004956];
prostaglandin F receptor activity [GO:0004958];
prostaglandin J receptor activity [GO:0001785]
Gene Ontology
(Cellular Component)
Complete annatation
integral component of plasma membrane [GO:0005887];
intracellular [GO:0005622];
neuron projection [GO:0043005];
plasma membrane [GO:0005886]
Protein-protein interaction116412
Phylogenetic treeQ9Y5Y4
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-5.738041526284700
AZA vs. DISU-0.4437032105936530.08158534700423130.60108383222961
AZA vs. IL7-0.2259661305476930.2440799838236730.994038428716508
AZA vs. SAHA-0.7527818191249350.002553915354896020.0395660021168577
DISU vs. CD35.285984872644500
DISU vs. IL70.2078931403662730.4132074526312740.771788173512136
DISU vs. SAHA-0.3076818377843470.3461443844116130.724044693611022
DMSO vs. AZA-0.001914739565696090.9909697920776441
DMSO vs. CD35.7243994067223500
DMSO vs. DISU0.4398138805541260.07361263139117910.506549020577657
DMSO vs. IL7-0.2167295479710070.2322567956418730.740647915971055
DMSO vs. SAHA-0.7566682821575050.001672592134417950.0258721058736955
HIV vs. Mock in Activationunknownunknownunknown
HIV vs. Mock in Latency-0.2956867703255020.1164676999235150.999834320637052
IL7 vs. CD35.5168729264705300
SAHA vs. CD34.9575051785806800
SAHA vs. IL7-0.529721670262760.03211021618693240.136886142195085
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) FALSE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -0.285242 0.613367
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

Drugbank ID Drug Name Drug Status Pharmacological Action Drug Action
DB00328 Indomethacin approved, investigational unknown other/unknown
DB00605 Sulindac approved unknown antagonist
DB04828 Zomepirac withdrawn unknown unknown

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
not found