Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0001187
UniProt IDP62873
Primary gene name(s)GNB1
Synonym gene name(s)unknown
Protein nameGuanine nucleotide-binding protein G(I/G(S/G(T subunit beta-1
Protein functionGuanine nucleotide-binding proteins, G proteins are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
Subcellular locationunknown
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P62873
Gene Ontology
(Biological Process)
Complete annatation
adenylate cyclase-activating dopamine receptor signaling pathway [GO:0007191];
cardiac muscle cell apoptotic process [GO:0010659];
cell proliferation [GO:0008283];
cellular response to catecholamine stimulus [GO:0071870];
cellular response to glucagon stimulus [GO:0071377];
cellular response to hypoxia [GO:0071456];
cellular response to prostaglandin E stimulus [GO:0071380];
G-protein coupled acetylcholine receptor signaling pathway [GO:0007213];
phospholipase C-activating G-protein coupled receptor signaling pathway [GO:0007200];
platelet activation [GO:0030168];
positive regulation of cytosolic calcium ion concentration [GO:0007204];
protein folding [GO:0006457];
protein heterotrimerization [GO:0070208];
Ras protein signal transduction [GO:0007265];
retina development in camera-type eye [GO:0060041];
rhodopsin mediated signaling pathway [GO:0016056];
sensory perception of taste [GO:0050909];
signal transduction [GO:0007165];
Wnt signaling pathway, calcium modulating pathway [GO:0007223]
Gene Ontology
(Molecular Function)
Complete annatation
GTPase activity [GO:0003924];
GTPase binding [GO:0051020];
protein complex binding [GO:0032403];
signal transducer activity [GO:0004871]
Gene Ontology
(Cellular Component)
Complete annatation
cell body [GO:0044297];
cytosol [GO:0005829];
dendrite [GO:0030425];
extracellular exosome [GO:0070062];
extracellular vesicle [GO:1903561];
heterotrimeric G-protein complex [GO:0005834];
intracellular [GO:0005622];
lysosomal membrane [GO:0005765];
membrane [GO:0016020];
myelin sheath [GO:0043209];
photoreceptor disc membrane [GO:0097381];
photoreceptor inner segment [GO:0001917];
photoreceptor outer segment membrane [GO:0042622];
plasma membrane [GO:0005886]
Protein-protein interaction109044
Phylogenetic treeP62873
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD30.3082559762632410.3461726217664650.466638547949172
AZA vs. DISU0.09751252803606530.6992470614322980.969609310121983
AZA vs. IL70.09268882568866740.6285421152244040.999311006273513
AZA vs. SAHA-0.148505769796410.5417426920931480.844253962329433
DISU vs. CD3-0.2231195767668340.5374802397293070.657841599032119
DISU vs. IL7-0.01411331203064450.955208548586640.992403092346216
DISU vs. SAHA-0.2440309445294510.4015249553205290.760893072002477
DMSO vs. AZA0.002255967584108550.9892080121771671
DMSO vs. CD3-0.3177092971829070.3199567837396720.432727259811307
DMSO vs. DISU-0.09716941789006730.6897243304912740.957954410639349
DMSO vs. IL70.09775696697405550.5852850166324250.909271241421904
DMSO vs. SAHA-0.156613703876440.5054332679364130.817491390971205
HIV vs. Mock in Activation0.1019190024520160.8697103744004970.999983755607037
HIV vs. Mock in Latency0.03217576364535760.8447884951342540.999834320637052
IL7 vs. CD3-0.2088195737217510.5149391187455640.643108570457527
SAHA vs. CD3-0.4805686155466410.1738423912504260.271034502416049
SAHA vs. IL7-0.2439076617773140.3155096813813310.564308606685118
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) FALSE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -0.404694 0.0244357
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
1.017 0.987 1.093 1.021 1.217
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
4KFM X-ray 3.4Å B=1-340.
4PNK X-ray 2.5Å B=1-340.
5HE0 X-ray 2.5Å B=2-340.
5HE1 X-ray 3.1Å B=2-340.
5HE2 X-ray 2.7Å B=2-340.
5HE3 X-ray 2.7Å B=2-340.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Vpr upregulates 23874603
Tat upregulates 23166591

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04014 Ras signaling pathway - Homo sapiens (human)
hsa04062 Chemokine signaling pathway - Homo sapiens (human)
hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
hsa04713 Circadian entrainment - Homo sapiens (human)
hsa04723 Retrograde endocannabinoid signaling - Homo sapiens (human)
hsa04724 Glutamatergic synapse - Homo sapiens (human)
hsa04725 Cholinergic synapse - Homo sapiens (human)
hsa04726 Serotonergic synapse - Homo sapiens (human)
hsa04727 GABAergic synapse - Homo sapiens (human)
hsa04728 Dopaminergic synapse - Homo sapiens (human)
hsa04740 Olfactory transduction - Homo sapiens (human)
hsa04744 Phototransduction - Homo sapiens (human)
hsa05032 Morphine addiction - Homo sapiens (human)
hsa05034 Alcoholism - Homo sapiens (human)
hsa05200 Pathways in cancer - Homo sapiens (human)