Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0001174
UniProt IDQ86SX6
Primary gene name(s)GLRX5
Synonym gene name(s)C14orf87
Protein nameGlutaredoxin-related protein 5, mitochondrial
Protein functionMonothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters, PubMed:20364084. Involved in protein lipoylation, acting in the pathway that provides an iron-sulfur cluster to lipoate synthase, PubMed:24334290. Required for normal iron homeostasis. Required for normal regulation of hemoglobin synthesis by the iron-sulfur protein ACO1, PubMed:20364084. May protect cells against apoptosis due to reactive oxygen species and oxidative stress, By similarity. {ECO:0000250|UniProtKB:Q80Y14, ECO:0000269|PubMed:20364084, ECO:0000269|PubMed:24334290}.
Subcellular locationMitochondrion matrix {ECO:0000269|PubMed:20364084}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q86SX6
Gene Ontology
(Biological Process)
Complete annatation
cell redox homeostasis [GO:0045454];
hemopoiesis [GO:0030097];
protein lipoylation [GO:0009249]
Gene Ontology
(Molecular Function)
Complete annatation
2 iron, 2 sulfur cluster binding [GO:0051537];
electron carrier activity [GO:0009055];
metal ion binding [GO:0046872];
protein disulfide oxidoreductase activity [GO:0015035]
Gene Ontology
(Cellular Component)
Complete annatation
dendrite [GO:0030425];
mitochondrial matrix [GO:0005759];
mitochondrion [GO:0005739];
neuronal cell body [GO:0043025];
nucleus [GO:0005634]
Protein-protein interaction119386
Phylogenetic treeQ86SX6
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD30.8207994598110190.01298216413840290.032594898866235
AZA vs. DISU-0.151682435319680.5520089217769340.946928765276725
AZA vs. IL7-0.04541906953796530.8158144348794540.999311006273513
AZA vs. SAHA0.02790119511691010.9100607435758750.980063563716391
DISU vs. CD3-0.9850210576550750.007307495229056160.0223135946081392
DISU vs. IL70.09714277822477260.7019571783338170.923741138299926
DISU vs. SAHA0.181237828813730.5393035718967260.845681420461508
DMSO vs. AZA-0.122135872178940.4749677704549111
DMSO vs. CD3-0.9544185619972750.003164209703144130.00931577470741964
DMSO vs. DISU0.02769416267118850.9103693446780620.988283279918411
DMSO vs. IL70.08412094288917640.6450604292244940.924086867864902
DMSO vs. SAHA0.1438285453356330.546958375611410.836857507789066
HIV vs. Mock in Activation0.04356321032717620.9443733281994130.999983755607037
HIV vs. Mock in Latency-0.0557370553085870.740804468134250.999834320637052
IL7 vs. CD3-0.8593123361717170.008073846644701010.0249891356212687
SAHA vs. CD3-0.8176618209360610.02181930034123350.0495504605398415
SAHA vs. IL70.07023291822105110.7757310987317530.90108536561587
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) FALSE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.108735 0.488017
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
1.021 0.898 0.951 1.049 0.966
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
2MMZ NMR - A=35-150.
2WUL X-ray 2.4Å A/B/C/D=35-150.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
retropepsin activated by 9325327

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
not found