Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0001168
UniProt IDO94923
Primary gene name(s)GLCE
Synonym gene name(s)KIAA0836
Protein nameD-glucuronyl C5-epimerase
Protein functionConverts D-glucuronic acid residues adjacent to N-sulfate sugar residues to L-iduronic acid residues, both in maturing heparan sulfate, HS and heparin chains. This is important for further modifications that determine the specificity of interactions between these glycosaminoglycans and proteins. {ECO:0000269|PubMed:20118238}.
Subcellular locationGolgi apparatus membrane {ECO:0000250};
Single-pass type II membrane protein {ECO:0000250}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: O94923
Gene Ontology
(Biological Process)
Complete annatation
heparan sulfate proteoglycan biosynthetic process [GO:0015012];
heparin biosynthetic process [GO:0030210]
Gene Ontology
(Molecular Function)
Complete annatation
heparosan-N-sulfate-glucuronate 5-epimerase activity [GO:0047464];
racemase and epimerase activity, acting on carbohydrates and derivatives [GO:0016857];
UDP-glucuronate 5'-epimerase activity [GO:0050379]
Gene Ontology
(Cellular Component)
Complete annatation
Golgi apparatus [GO:0005794];
Golgi membrane [GO:0000139];
integral component of membrane [GO:0016021]
Protein-protein interaction117501
Phylogenetic treeO94923
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD30.5511442417343040.1110006158403750.191418910977818
AZA vs. DISU-0.3250017122796310.2779189766775190.848297901951307
AZA vs. IL7-0.08291944332262970.7323547939085150.999311006273513
AZA vs. SAHA0.9657280642573610.0003659576893165760.0102068296627987
DISU vs. CD3-0.8904549562014880.02000910109323080.0514121976204687
DISU vs. IL70.2347922362287940.4994541595999690.825849671599158
DISU vs. SAHA1.293919753481656.70154129774891e-050.00283704856456106
DMSO vs. AZA0.07131691502321530.735420134348411
DMSO vs. CD3-0.4900643859453990.1449462757451620.230801780372145
DMSO vs. DISU0.3962278748261290.1999723841686680.716326082581848
DMSO vs. IL7-0.1477532717744890.5603387309259320.901163922289321
DMSO vs. SAHA0.8892475686599850.000644817723838620.0129761676876407
HIV vs. Mock in Activation0.1563814709772960.8073495385380850.999983755607037
HIV vs. Mock in Latency0.2852799350659830.3658926290355840.999834320637052
IL7 vs. CD3-0.6288538358802540.06471001731367710.135037254737513
SAHA vs. CD30.3929406350372040.2853754241559810.398462674143485
SAHA vs. IL71.049642548750810.0001165612239634180.00220457200755906
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) TRUE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.0726041 0.793075
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Tat upregulates 24667918

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin - Homo sapiens (human)
hsa01100 Metabolic pathways - Homo sapiens (human)