Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0001154
UniProt IDP56159
Primary gene name(s)GFRA1
Synonym gene name(s)GDNFRA, RETL1, TRNR1
Protein nameGDNF family receptor alpha-1
Protein functionReceptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor, By similarity. {ECO:0000250}.
Subcellular locationCell membrane {ECO:0000250};
Lipid-anchor, GPI-anchor {ECO:0000250}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P56159
Gene Ontology
(Biological Process)
Complete annatation
cell surface receptor signaling pathway [GO:0007166];
MAPK cascade [GO:0000165];
nervous system development [GO:0007399]
Gene Ontology
(Molecular Function)
Complete annatation
glial cell-derived neurotrophic factor receptor activity [GO:0016167];
Ras guanyl-nucleotide exchange factor activity [GO:0005088];
receptor binding [GO:0005102]
Gene Ontology
(Cellular Component)
Complete annatation
anchored component of membrane [GO:0031225];
extracellular exosome [GO:0070062];
extrinsic component of membrane [GO:0019898];
intracellular [GO:0005622];
plasma membrane [GO:0005886]
Protein-protein interaction108942
Phylogenetic treeP56159
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
      unknown
Brass et al., Science, 2008
      unknown
Smith et al., J. Immunol, 2010
      unknown
Interferon-stimulated
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model


DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-1.720782689702870.1601949193752880.25642075454804
AZA vs. DISU-0.782944809650510.484590794617560.931429104131977
AZA vs. IL7-0.3790176310780630.7135452938853630.999311006273513
AZA vs. SAHA-0.3280836074170370.7802960363960310.941501837239556
DISU vs. CD30.9242994117200470.4643999894404340.593217309295928
DISU vs. IL70.3978494388533370.7015835701827080.923731081825003
DISU vs. SAHA0.4516075421796570.7002117240041010.911067158116707
DMSO vs. AZA-0.06918199324625430.9478982691665791
DMSO vs. CD31.622044306836880.1363932973344220.219902078803839
DMSO vs. DISU0.7066214758765570.5062874411759250.910656316859227
DMSO vs. IL7-0.3001222868385390.7534957543016010.951631847120623
DMSO vs. SAHA-0.2670870022610720.8124504669443090.948464420150524
HIV vs. Mock in Activation-1.94216868299690.02792411549601910.999983755607037
HIV vs. Mock in Latency-1.183265947152550.1295320977641550.999834320637052
IL7 vs. CD31.357805137839350.1900311003378930.310187749479371
SAHA vs. CD31.359389243125840.3131019199172580.427279356438746
SAHA vs. IL70.03953425293358710.9714793599236460.989783805884461
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) FALSE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value