Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0001138
UniProt IDP23771
Primary gene name(s)GATA3
Synonym gene name(s)unknown
Protein nameTrans-acting T-cell-specific transcription factor GATA-3
Protein functionTranscriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'. Required for the T-helper 2, Th2 differentiation process following immune and inflammatory responses. {ECO:0000269|PubMed:23824597}.
Subcellular locationNucleus.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P23771
Gene Ontology
(Biological Process)
Complete annatation
anatomical structure formation involved in morphogenesis [GO:0048646];
anatomical structure morphogenesis [GO:0009653];
animal organ morphogenesis [GO:0009887];
aortic valve morphogenesis [GO:0003180];
axon guidance [GO:0007411];
blood coagulation [GO:0007596];
canonical Wnt signaling pathway involved in metanephric kidney development [GO:0061290];
cardiac right ventricle morphogenesis [GO:0003215];
cell fate commitment [GO:0045165];
cell fate determination [GO:0001709];
cell maturation [GO:0048469];
cellular response to BMP stimulus [GO:0071773];
cellular response to interferon-alpha [GO:0035457];
cellular response to interleukin-4 [GO:0071353];
cellular response to tumor necrosis factor [GO:0071356];
chromatin remodeling [GO:0006338];
cochlea development [GO:0090102];
defense response [GO:0006952];
developmental growth [GO:0048589];
digestive tract development [GO:0048565];
ear development [GO:0043583];
embryonic hemopoiesis [GO:0035162];
erythrocyte differentiation [GO:0030218];
heart development [GO:0007507];
humoral immune response [GO:0006959];
innate immune response [GO:0045087];
inner ear morphogenesis [GO:0042472];
interferon-gamma secretion [GO:0072643];
interleukin-4 secretion [GO:0072602];
in utero embryonic development [GO:0001701];
kidney development [GO:0001822];
lens development in camera-type eye [GO:0002088];
lymphocyte migration [GO:0072676];
male gonad development [GO:0008584];
mast cell differentiation [GO:0060374];
mesenchymal to epithelial transition [GO:0060231];
mesonephros development [GO:0001823];
negative regulation of cell cycle [GO:0045786];
negative regulation of cell motility [GO:2000146];
negative regulation of cell proliferation [GO:0008285];
negative regulation of cell proliferation involved in mesonephros development [GO:2000607];
negative regulation of DNA demethylation [GO:1901536];
negative regulation of endothelial cell apoptotic process [GO:2000352];
negative regulation of fat cell differentiation [GO:0045599];
negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation [GO:2000703];
negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation [GO:2000734];
negative regulation of inflammatory response [GO:0050728];
negative regulation of interferon-gamma production [GO:0032689];
negative regulation of interleukin-2 production [GO:0032703];
negative regulation of mammary gland epithelial cell proliferation [GO:0033600];
negative regulation of transcription, DNA-templated [GO:0045892];
nephric duct formation [GO:0072179];
nephric duct morphogenesis [GO:0072178];
neuron migration [GO:0001764];
norepinephrine biosynthetic process [GO:0042421];
otic vesicle development [GO:0071599];
parathyroid gland development [GO:0060017];
parathyroid hormone secretion [GO:0035898];
pharyngeal system development [GO:0060037];
phosphatidylinositol 3-kinase signaling [GO:0014065];
positive regulation of endothelial cell migration [GO:0010595];
positive regulation of histone H3-K14 acetylation [GO:0071442];
positive regulation of histone H3-K9 acetylation [GO:2000617];
positive regulation of interleukin-13 secretion [GO:2000667];
positive regulation of interleukin-4 production [GO:0032753];
positive regulation of interleukin-5 secretion [GO:2000664];
positive regulation of protein kinase B signaling [GO:0051897];
positive regulation of signal transduction [GO:0009967];
positive regulation of T cell differentiation [GO:0045582];
positive regulation of T-helper 2 cell cytokine production [GO:2000553];
positive regulation of thyroid hormone generation [GO:2000611];
positive regulation of transcription, DNA-templated [GO:0045893];
positive regulation of transcription from RNA polymerase II promoter [GO:0045944];
positive regulation of transcription regulatory region DNA binding [GO:2000679];
positive regulation of ureteric bud formation [GO:0072107];
post-embryonic development [GO:0009791];
pro-T cell differentiation [GO:0002572];
regulation of CD4-positive, alpha-beta T cell differentiation [GO:0043370];
regulation of cellular response to X-ray [GO:2000683];
regulation of cytokine biosynthetic process [GO:0042035];
regulation of establishment of cell polarity [GO:2000114];
regulation of histone H3-K27 methylation [GO:0061085];
regulation of histone H3-K4 methylation [GO:0051569];
regulation of nephron tubule epithelial cell differentiation [GO:0072182];
regulation of neuron apoptotic process [GO:0043523];
regulation of neuron projection development [GO:0010975];
response to drug [GO:0042493];
response to estrogen [GO:0043627];
response to ethanol [GO:0045471];
response to gamma radiation [GO:0010332];
response to virus [GO:0009615];
signal transduction [GO:0007165];
sympathetic nervous system development [GO:0048485];
T cell receptor signaling pathway [GO:0050852];
T-helper 2 cell differentiation [GO:0045064];
thymic T cell selection [GO:0045061];
thymus development [GO:0048538];
TOR signaling [GO:0031929];
transcription from RNA polymerase II promoter [GO:0006366];
type IV hypersensitivity [GO:0001806];
ureteric bud formation [GO:0060676];
ureter maturation [GO:0035799];
uterus development [GO:0060065];
ventricular septum development [GO:0003281]
Gene Ontology
(Molecular Function)
Complete annatation
chromatin binding [GO:0003682];
core promoter proximal region sequence-specific DNA binding [GO:0000987];
core promoter sequence-specific DNA binding [GO:0001046];
DNA binding [GO:0003677];
E-box binding [GO:0070888];
enhancer sequence-specific DNA binding [GO:0001158];
HMG box domain binding [GO:0071837];
nucleic acid binding transcription factor activity [GO:0001071];
RNA polymerase II core promoter sequence-specific DNA binding [GO:0000979];
RNA polymerase II regulatory region sequence-specific DNA binding [GO:0000977];
RNA polymerase II transcription factor binding [GO:0001085];
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding [GO:0001077];
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding [GO:0001228];
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding [GO:0001078];
transcription coactivator activity [GO:0003713];
transcription factor activity, sequence-specific DNA binding [GO:0003700];
transcription factor binding [GO:0008134];
transcription regulatory region DNA binding [GO:0044212];
transcription regulatory region sequence-specific DNA binding [GO:0000976];
zinc ion binding [GO:0008270]
Gene Ontology
(Cellular Component)
Complete annatation
nuclear chromatin [GO:0000790];
nucleolus [GO:0005730];
nucleoplasm [GO:0005654];
nucleus [GO:0005634];
transcription factor complex [GO:0005667]
Protein-protein interaction108895
Phylogenetic treeP23771
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
      unknown
Brass et al., Science, 2008
      unknown
Smith et al., J. Immunol, 2010
      unknown
Interferon-stimulated
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model


DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD30.883021669557290.007536058975174180.0205024333707266
AZA vs. DISU-0.05741369369502440.8203340871107480.984374783402915
AZA vs. IL7-0.3340230340214330.08308730308509570.793510026625927
AZA vs. SAHA0.1611791891797610.5094594308528150.826837323254868
DISU vs. CD3-0.9527743256473490.009284338802963420.0272227432631532
DISU vs. IL7-0.2858961627663670.257148172331980.642760497037037
DISU vs. SAHA0.220421182131930.450237359963120.792146538875109
DMSO vs. AZA-0.02057188097219880.9023227246135631
DMSO vs. CD3-0.9166175960932430.00447551466358520.0124858571123909
DMSO vs. DISU0.03458666615620410.8872305074948680.987802141379617
DMSO vs. IL7-0.305910088596430.08946380278268420.555800284824665
DMSO vs. SAHA0.1760687300515440.4553931839048880.785356525303875
HIV vs. Mock in Activation0.251901046221420.6864340176490050.999983755607037
HIV vs. Mock in Latency-0.005665644339507590.9725874517410670.999834320637052
IL7 vs. CD3-1.21033340226290.0002005142521859240.00106872394738275
SAHA vs. CD3-0.7458761687480630.03547831928548150.0747669237354505
SAHA vs. IL70.4915726951673160.04395710896202690.168431484619622
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) FALSE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -1.14311 0.00261319
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
-0.033 2.98E-04

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
4HC7 X-ray 2.6Å A/B=260-370.
4HC9 X-ray 1.6Å A=260-370.
4HCA X-ray 2.8Å A=260-370.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Nef binds 12767938

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04658 Th1 and Th2 cell differentiation - Homo sapiens (human)
hsa04659 Th17 cell differentiation - Homo sapiens (human)
hsa05321 Inflammatory bowel disease (IBD) - Homo sapiens (human)
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