Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0001117
UniProt IDQ13467
Primary gene name(s)FZD5
Synonym gene name(s)C2orf31
Protein nameFrizzled-5
Protein functionReceptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Interacts specifically with Wnt5A to induce the beta-catenin pathway. {ECO:0000269|PubMed:10097073}.
Subcellular locationCell membrane {ECO:0000250};
Multi-pass membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250};
Multi-pass membrane protein {ECO:0000250}. Note=Localized at the plasma membrane and also found at the Golgi. {ECO:0000250}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q13467
Gene Ontology
(Biological Process)
Complete annatation
angiogenesis [GO:0001525];
anterior/posterior axis specification, embryo [GO:0008595];
apoptotic process involved in morphogenesis [GO:0060561];
beta-catenin destruction complex disassembly [GO:1904886];
branching involved in labyrinthine layer morphogenesis [GO:0060670];
canonical Wnt signaling pathway [GO:0060070];
cell maturation [GO:0048469];
cellular response to molecule of bacterial origin [GO:0071219];
chorionic trophoblast cell differentiation [GO:0060718];
embryonic axis specification [GO:0000578];
embryonic camera-type eye morphogenesis [GO:0048596];
labyrinthine layer blood vessel development [GO:0060716];
negative regulation of cell proliferation [GO:0008285];
neuron differentiation [GO:0030182];
non-canonical Wnt signaling pathway [GO:0035567];
positive regulation of interferon-gamma production [GO:0032729];
positive regulation of JUN kinase activity [GO:0043507];
positive regulation of protein targeting to mitochondrion [GO:1903955];
positive regulation of T cell cytokine production [GO:0002726];
positive regulation of transcription from RNA polymerase II promoter [GO:0045944];
post-embryonic camera-type eye development [GO:0031077];
regulation of bicellular tight junction assembly [GO:2000810];
regulation of canonical Wnt signaling pathway [GO:0060828];
regulation of chorionic trophoblast cell proliferation [GO:1901382];
regulation of mitophagy [GO:1903146];
Spemann organizer formation [GO:0060061];
synapse assembly [GO:0007416];
syncytiotrophoblast cell differentiation involved in labyrinthine layer development [GO:0060715];
T cell differentiation in thymus [GO:0033077];
Wnt signaling pathway, calcium modulating pathway [GO:0007223];
Wnt signaling pathway, planar cell polarity pathway [GO:0060071];
Wnt signaling pathway involved in dorsal/ventral axis specification [GO:0044332]
Gene Ontology
(Molecular Function)
Complete annatation
beta-amyloid binding [GO:0001540];
G-protein coupled receptor activity [GO:0004930];
protein kinase binding [GO:0019901];
ubiquitin protein ligase binding [GO:0031625];
Wnt-activated receptor activity [GO:0042813];
Wnt-protein binding [GO:0017147]
Gene Ontology
(Cellular Component)
Complete annatation
bicellular tight junction [GO:0005923];
cell surface [GO:0009986];
clathrin-coated endocytic vesicle membrane [GO:0030669];
early endosome membrane [GO:0031901];
Golgi membrane [GO:0000139];
integral component of membrane [GO:0016021];
perinuclear region of cytoplasm [GO:0048471];
plasma membrane [GO:0005886]
Protein-protein interaction113609
Phylogenetic treeQ13467
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD32.83056204966327.32765292887905e-101.08917539392569e-08
AZA vs. DISUunknownunknownunknown
AZA vs. IL7unknownunknownunknown
AZA vs. SAHAunknownunknownunknown
DISU vs. CD3-2.81573819920212.72116773558650e-117.58204851131811e-10
DISU vs. IL7unknownunknownunknown
DISU vs. SAHAunknownunknownunknown
DMSO vs. AZAunknownunknownunknown
DMSO vs. CD3-2.729898876193572.52575738102223e-136.0934377543731e-12
DMSO vs. DISUunknownunknownunknown
DMSO vs. IL7unknownunknownunknown
DMSO vs. SAHAunknownunknownunknown
HIV vs. Mock in Activation0.5032031165902810.4405215804284040.999983755607037
HIV vs. Mock in Latencyunknownunknownunknown
IL7 vs. CD3-2.89845202076842.73114864057789e-149.84846972713647e-13
SAHA vs. CD3-1.420422601295140.02215251636765450.0502012664151207
SAHA vs. IL7unknownunknownunknown
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) TRUE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.7631 0.00282334
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04150 mTOR signaling pathway - Homo sapiens (human)
hsa04310 Wnt signaling pathway - Homo sapiens (human)
hsa04390 Hippo signaling pathway - Homo sapiens (human)
hsa04550 Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)
hsa04916 Melanogenesis - Homo sapiens (human)
hsa05166 HTLV-I infection - Homo sapiens (human)
hsa05200 Pathways in cancer - Homo sapiens (human)
hsa05205 Proteoglycans in cancer - Homo sapiens (human)
hsa05217 Basal cell carcinoma - Homo sapiens (human)
hsa05224 Breast cancer - Homo sapiens (human)