Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0001116
UniProt IDQ9NPG1
Primary gene name(s)FZD3
Synonym gene name(s)unknown
Protein nameFrizzled-3
Protein functionReceptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Activation by Wnt5A stimulates PKC activity via a G-protein-dependent mechanism. Involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Plays a role in controlling early axon growth and guidance processes necessary for the formation of a subset of central and peripheral major fiber tracts. Required for the development of major fiber tracts in the central nervous system, including: the anterior commissure, the corpus callosum, the thalamocortical, corticothalamic and nigrostriatal tracts, the corticospinal tract, the fasciculus retroflexus, the mammillothalamic tract, the medial lemniscus, and ascending fiber tracts from the spinal cord to the brain. In the peripheral nervous system, controls axon growth in distinct populations of cranial and spinal motor neurons, including the facial branchimotor nerve, the hypoglossal nerve, the phrenic nerve, and motor nerves innervating dorsal limbs. Involved in the migration of cranial neural crest cells. May also be implicated in the transmission of sensory information from the trunk and limbs to the brain. Controls commissural sensory axons guidance after midline crossing along the anterior-posterior axis in the developing spinal cord in a Wnt-dependent signaling pathway. Together with FZD6, is involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity, PCP, particularly in the orientation of asymmetric bundles of stereocilia on the apical faces of a subset of auditory and vestibular sensory cells located in the inner ear. Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle in a beta-catenin-dependent manner, By similarity. {ECO:0000250|UniProtKB:Q61086}.
Subcellular locationMembrane;
Multi-pass membrane protein. Cell membrane {ECO:0000250};
Multi-pass membrane protein {ECO:0000250}. Cell surface {ECO:0000250|UniProtKB:Q61086}. Apical cell membrane {ECO:0000250|UniProtKB:Q61086};
Multi-pass membrane protein. Note=Colocalizes with FZD6 at the apical face of the cell, By similarity. {ECO:0000250|UniProtKB:Q61086}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q9NPG1
Gene Ontology
(Biological Process)
Complete annatation
canonical Wnt signaling pathway [GO:0060070];
cell proliferation in midbrain [GO:0033278];
commissural neuron axon guidance [GO:0071679];
dopaminergic neuron axon guidance [GO:0036514];
establishment of planar polarity [GO:0001736];
hair follicle development [GO:0001942];
inner ear morphogenesis [GO:0042472];
midbrain morphogenesis [GO:1904693];
negative regulation of execution phase of apoptosis [GO:1900118];
negative regulation of mitotic cell cycle, embryonic [GO:0045976];
neural tube closure [GO:0001843];
neuron differentiation [GO:0030182];
neuron migration [GO:0001764];
non-canonical Wnt signaling pathway [GO:0035567];
planar cell polarity pathway involved in axon guidance [GO:1904938];
positive regulation of neuroblast proliferation [GO:0002052];
post-anal tail morphogenesis [GO:0036342];
response to drug [GO:0042493];
response to electrical stimulus [GO:0051602];
serotonergic neuron axon guidance [GO:0036515];
sympathetic ganglion development [GO:0061549];
Wnt signaling pathway, calcium modulating pathway [GO:0007223];
Wnt signaling pathway, planar cell polarity pathway [GO:0060071]
Gene Ontology
(Molecular Function)
Complete annatation
G-protein coupled receptor activity [GO:0004930];
PDZ domain binding [GO:0030165];
Wnt-activated receptor activity [GO:0042813];
Wnt-protein binding [GO:0017147]
Gene Ontology
(Cellular Component)
Complete annatation
apical plasma membrane [GO:0016324];
axon [GO:0030424];
cell surface [GO:0009986];
cytoplasm [GO:0005737];
dendrite [GO:0030425];
filopodium tip [GO:0032433];
integral component of membrane [GO:0016021];
lateral plasma membrane [GO:0016328];
neuronal cell body [GO:0043025];
plasma membrane [GO:0005886];
presynaptic active zone [GO:0048786]
Protein-protein interaction113689
Phylogenetic treeQ9NPG1
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
      unknown
Brass et al., Science, 2008
      unknown
Smith et al., J. Immunol, 2010
      unknown
Interferon-stimulated
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model


DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD32.02386913381074.56697824002816e-095.7794706997233e-08
AZA vs. DISU0.203101972869690.6664159332926730.962297595817978
AZA vs. IL70.01529966216248890.9512223606577060.999311006273513
AZA vs. SAHA1.061176718877530.0005331231006600050.0133715434598152
DISU vs. CD3-1.835552472413452.75444817336989e-050.000181470943030497
DISU vs. IL7-0.1928857703616020.6697903154793180.908802354102415
DISU vs. SAHA0.8591420401433560.07627654233788150.349849654184613
DMSO vs. AZA-0.1270206419453870.5648960204027011
DMSO vs. CD3-2.163361237899611.68251634846683e-102.53979045988505e-09
DMSO vs. DISU-0.3306626319789630.4526648787544570.889163154696256
DMSO vs. IL70.1482898310972960.4636601094070450.87615725294193
DMSO vs. SAHA1.178556934717953.4373127942855e-060.000229220093463171
HIV vs. Mock in Activation0.123675162376260.8431906918817490.999983755607037
HIV vs. Mock in Latency0.1156885502836450.5597964706607310.999834320637052
IL7 vs. CD3-1.997232537593943.42876727010832e-095.58722260133435e-08
SAHA vs. CD3-0.9903838717680190.005910507768140620.0164459660387517
SAHA vs. IL71.037957250103660.0001878506291108640.00320323572762123
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) TRUE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -0.404983 0.0104019
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04150 mTOR signaling pathway - Homo sapiens (human)
hsa04310 Wnt signaling pathway - Homo sapiens (human)
hsa04360 Axon guidance - Homo sapiens (human)
hsa04390 Hippo signaling pathway - Homo sapiens (human)
hsa04550 Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)
hsa04916 Melanogenesis - Homo sapiens (human)
hsa05166 HTLV-I infection - Homo sapiens (human)
hsa05200 Pathways in cancer - Homo sapiens (human)
hsa05205 Proteoglycans in cancer - Homo sapiens (human)
hsa05206 MicroRNAs in cancer - Homo sapiens (human)
hsa05217 Basal cell carcinoma - Homo sapiens (human)
hsa05224 Breast cancer - Homo sapiens (human)
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