Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0001111
UniProt IDP09958
Primary gene name(s)FURIN
Synonym gene name(s)FUR, PACE, PCSK3
Protein nameFurin
Protein functionFurin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/RR consensus motif. {ECO:0000269|PubMed:7690548}.
Subcellular locationGolgi apparatus, trans-Golgi network membrane;
Single-pass type I membrane protein. Cell membrane;
Single-pass type I membrane protein. Note=Shuttles between the trans-Golgi network and the cell surface. Propeptide cleavage is a prerequisite for exit of furin molecules out of the endoplasmic reticulum, ER. A second cleavage within the propeptide occurs in the trans Golgi network, TGN, followed by the release of the propeptide and the activation of furin.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P09958
Gene Ontology
(Biological Process)
Complete annatation
cell proliferation [GO:0008283];
cellular protein metabolic process [GO:0044267];
collagen catabolic process [GO:0030574];
extracellular matrix disassembly [GO:0022617];
extracellular matrix organization [GO:0030198];
negative regulation of low-density lipoprotein particle receptor catabolic process [GO:0032804];
negative regulation of transforming growth factor beta1 production [GO:0032911];
nerve growth factor processing [GO:0032455];
nerve growth factor production [GO:0032902];
peptide biosynthetic process [GO:0043043];
peptide hormone processing [GO:0016486];
positive regulation of membrane protein ectodomain proteolysis [GO:0051044];
protein processing [GO:0016485];
regulation of endopeptidase activity [GO:0052548];
regulation of low-density lipoprotein particle receptor biosynthetic process [GO:0045714];
regulation of protein catabolic process [GO:0042176];
regulation of signal transduction [GO:0009966];
secretion by cell [GO:0032940];
signal peptide processing [GO:0006465];
transforming growth factor beta receptor signaling pathway [GO:0007179];
viral life cycle [GO:0019058];
viral protein processing [GO:0019082]
Gene Ontology
(Molecular Function)
Complete annatation
endopeptidase activity [GO:0004175];
metal ion binding [GO:0046872];
nerve growth factor binding [GO:0048406];
peptidase activity [GO:0008233];
peptide binding [GO:0042277];
protease binding [GO:0002020];
serine-type endopeptidase activity [GO:0004252];
serine-type endopeptidase inhibitor activity [GO:0004867]
Gene Ontology
(Cellular Component)
Complete annatation
cell surface [GO:0009986];
endoplasmic reticulum [GO:0005783];
endoplasmic reticulum membrane [GO:0005789];
extracellular exosome [GO:0070062];
Golgi cisterna [GO:0031985];
Golgi lumen [GO:0005796];
Golgi membrane [GO:0000139];
integral component of membrane [GO:0016021];
membrane [GO:0016020];
membrane raft [GO:0045121];
plasma membrane [GO:0005886];
trans-Golgi network [GO:0005802];
trans-Golgi network transport vesicle [GO:0030140]
Protein-protein interaction111082
Phylogenetic treeP09958
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD30.7916087995537190.02513653725315970.0561936946721481
AZA vs. DISU-0.03456649515575440.9084439138684830.994169411479968
AZA vs. IL70.3829869448101280.07662607277032580.773641548161711
AZA vs. SAHA-0.5450182486335850.03317698450480520.211016820432673
DISU vs. CD3-0.8379432812010720.03072258688490360.0729299695364799
DISU vs. IL70.4079101697620430.1260162341408710.46481397838846
DISU vs. SAHA-0.5071446756088760.08850945955237060.379279518030644
DMSO vs. AZA0.02502158434176740.9059801535648191
DMSO vs. CD3-0.7765065286085230.01742196928891470.0398403913388369
DMSO vs. DISU0.05827089855889410.8262871559273370.980747352324641
DMSO vs. IL70.3651640626527480.04181831083766590.413125799360737
DMSO vs. SAHA-0.5747933297398650.0148518809330220.116035613033476
HIV vs. Mock in Activation0.2734831424058850.6810998569301490.999983755607037
HIV vs. Mock in Latency0.1359857670025880.4112070992084750.999834320637052
IL7 vs. CD3-0.4037390561612750.2138418430359320.339252510270561
SAHA vs. CD3-1.358335748583990.0001759146151930620.000787123886864445
SAHA vs. IL7-0.9294059203484470.0001481565438101740.00265238924156124
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander 1.004 3.40E-12 6.22E-10
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change 1.113713183
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) TRUE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.5483 0.000305467
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

Drugbank ID Drug Name Drug Status Pharmacological Action Drug Action
DB04951 Pirfenidone investigational unknown unknown
DB03600 Decanoic Acid experimental unknown unknown

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
4OMC X-ray 2.3Å A/B/C/D/E/F=108-574.
4OMD X-ray 2.7Å A/B/C/D/E/F=108-574.
4RYD X-ray 2.1Å A/B/C/D/E/F=108-574.
4Z2A X-ray 1.8Å A=110-574.
5JXG X-ray 1.8Å A=108-574.
5JXH X-ray 2.0Å A=108-574.
5JXI X-ray 2.0Å A=108-574.
5JXJ X-ray 2.0Å A=108-574.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Tat cleaved by 15135058
Envelope surface glycoprotein gp160; precursor cleaved by 1360148
Envelope surface glycoprotein gp160; precursor inhibits 26283733
Envelope surface glycoprotein gp120 upregulates 24162774

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa05164 Influenza A - Homo sapiens (human)