Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0001107
UniProt IDQ9UI43
Primary gene name(s)MRM2
Synonym gene name(s)FJH1, FTSJ2
Protein namerRNA methyltransferase 2, mitochondrial
Protein functionS-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methyluridine at position 1369, Um1369 in the 16S mitochondrial large subunit ribosomal RNA, mtLSU rRNA, a universally conserved modification in the peptidyl transferase domain of the mtLSU rRNA. {ECO:0000269|PubMed:25009282, ECO:0000269|PubMed:25074936}.
Subcellular locationMitochondrion {ECO:0000269|PubMed:24036117, ECO:0000269|PubMed:25009282}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q9UI43
Gene Ontology
(Biological Process)
Complete annatation
cell proliferation [GO:0008283];
enzyme-directed rRNA 2'-O-methylation [GO:0000453];
rRNA methylation [GO:0031167];
rRNA processing [GO:0006364]
Gene Ontology
(Molecular Function)
Complete annatation
rRNA, uridine-2'-O--methyltransferase activity [GO:0008650]
Gene Ontology
(Cellular Component)
Complete annatation
mitochondrion [GO:0005739];
nucleolus [GO:0005730]
Protein-protein interaction118996
Phylogenetic treeQ9UI43
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD31.141255592682290.0006227573264924180.00240425164572073
AZA vs. DISU-0.3419447747854090.1807361813266930.766362080820978
AZA vs. IL70.1017740248189920.6015140394623970.999311006273513
AZA vs. SAHA-0.1888436926856060.4435367723956740.788183866617569
DISU vs. CD3-1.495111385352616.20394959046644e-050.000372731511066924
DISU vs. IL70.4341738030233460.08790329272646960.392053886938322
DISU vs. SAHA0.1549036577381330.5973317282894270.87092070376582
DMSO vs. AZA-0.02264920395053630.8945395418119621
DMSO vs. CD3-1.173451366427590.0003176131144910780.00124865385433405
DMSO vs. DISU0.3179214648611810.1968533085037170.713677194394938
DMSO vs. IL70.1313857385469620.4712841050459970.87843882522273
DMSO vs. SAHA-0.1727117838578360.4681499912892910.794089872675397
HIV vs. Mock in Activation-0.007501130853274260.9903949322987450.999983755607037
HIV vs. Mock in Latency-0.0007868753293025080.9962647542513770.999834320637052
IL7 vs. CD3-1.032623351594130.00153973847578970.00615446248888309
SAHA vs. CD3-1.353971673924550.000189453180482690.000842946392050235
SAHA vs. IL7-0.2928671480147980.2337338849329270.474252713010292
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) FALSE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.185216 0.203473
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
2NYU X-ray 1.7Å A/B=51-246.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
not found