Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0001104
UniProt IDO43559
Primary gene name(s)FRS3
Synonym gene name(s)unknown
Protein nameFibroblast growth factor receptor substrate 3
Protein functionAdapter protein that links FGF and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Down-regulates ERK2 signaling by interfering with the phosphorylation and nuclear translocation of ERK2. {ECO:0000269|PubMed:15094036}.
Subcellular locationMembrane;
ECO codeClick here for more information.
Amino acid sequence
FASTA format: O43559
Gene Ontology
(Biological Process)
Complete annatation
fibroblast growth factor receptor signaling pathway [GO:0008543];
MAPK cascade [GO:0000165];
signal transduction [GO:0007165]
Gene Ontology
(Molecular Function)
Complete annatation
fibroblast growth factor receptor binding [GO:0005104];
identical protein binding [GO:0042802];
Ras guanyl-nucleotide exchange factor activity [GO:0005088]
Gene Ontology
(Cellular Component)
Complete annatation
intracellular [GO:0005622];
plasma membrane [GO:0005886]
Protein-protein interaction116030
Phylogenetic treeO43559
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-0.01299842977223870.9692801207456940.979023587982784
AZA vs. DISU-0.1687730695271120.5281537458155050.940949166421897
AZA vs. IL7-0.1206900352970610.5797730726258610.999311006273513
AZA vs. SAHA0.4322013752093640.09361992832553130.38504239334546
DISU vs. CD3-0.1686606590338010.6492877781529780.750292215055554
DISU vs. IL70.0374294018495470.8879856011248990.979940654995064
DISU vs. SAHA0.6040691246554620.04655029796529230.267933296985056
DMSO vs. AZA-0.008047290167473770.9661617500233561
DMSO vs. CD3-0.0118594256147890.9712487948294550.980162318736987
DMSO vs. DISU0.1571888903769860.542070885913550.92165367766982
DMSO vs. IL7-0.1039311787160250.60147062999420.912604767320708
DMSO vs. SAHA0.4379604393567860.07810662124729970.326350121657348
HIV vs. Mock in Activation0.1492857878930150.8145172267354350.999983755607037
HIV vs. Mock in Latency-0.1149236277363120.5236810617855170.999834320637052
IL7 vs. CD3-0.1051112977142090.7509508844009320.834309919700395
SAHA vs. CD30.4225510197503840.2438438823964190.352458019155384
SAHA vs. IL70.5528508473387010.0322292283212950.137160753166347
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) TRUE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.23891 0.250386
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
2KUP NMR - A=8-146.
2KUQ NMR - A=8-120.
2YS5 NMR - A=8-146.
2YT2 NMR - A=8-120.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
not found