Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0001092
UniProt IDQ8TF40
Primary gene name(s)FNIP1
Synonym gene name(s)KIAA1961
Protein nameFolliculin-interacting protein 1
Protein functionActs as a co-chaperone of HSP90AA1. Inhibits the ATPase activity of HSP90AA1 leading to reduction in its chaperone activity. Facilitates the binding of client protein FLCN to HSP90AA1. Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins, PubMed:27353360. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways, PubMed:17028174. May regulate phosphorylation of RPS6KB1, PubMed:18663353. {ECO:0000269|PubMed:17028174, ECO:0000269|PubMed:18663353, ECO:0000269|PubMed:27353360}.
Subcellular locationCytoplasm {ECO:0000269|PubMed:18663353}. Note=Colocalizes with FLCN in the cytoplasm.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q8TF40
Gene Ontology
(Biological Process)
Complete annatation
cellular response to starvation [GO:0009267];
immature B cell differentiation [GO:0002327];
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154];
negative regulation of TOR signaling [GO:0032007];
negative regulation of transcription from RNA polymerase II promoter [GO:0000122];
positive regulation of B cell apoptotic process [GO:0002904];
positive regulation of peptidyl-serine phosphorylation [GO:0033138];
positive regulation of protein complex assembly [GO:0031334];
positive regulation of protein phosphorylation [GO:0001934];
regulation of pro-B cell differentiation [GO:2000973];
regulation of protein phosphorylation [GO:0001932];
TOR signaling [GO:0031929]
Gene Ontology
(Molecular Function)
Complete annatation
guanyl-nucleotide exchange factor activity [GO:0005085]
Gene Ontology
(Cellular Component)
Complete annatation
cytoplasm [GO:0005737]
Protein-protein interaction125175
Phylogenetic treeQ8TF40
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-0.4013999621370220.2228386984013270.331454146087516
AZA vs. DISU0.4154910898206570.1009529804964320.642366073450068
AZA vs. IL7-0.1286847451159230.5032833130019680.999311006273513
AZA vs. SAHA-0.101467836321760.677344084217720.905920284023018
DISU vs. CD30.8034102158899030.0290276274251340.0696866468874773
DISU vs. IL7-0.5527842493369160.02860346241680490.217446896587662
DISU vs. SAHA-0.5163243628306520.07690202533952250.351315678657758
DMSO vs. AZA-0.08615530449428250.6070918372351641
DMSO vs. CD30.3038519285907060.3445018060402920.458676067874237
DMSO vs. DISU-0.5035034297045960.03948385670793510.398866336139429
DMSO vs. IL7-0.0353625891413060.8440910575786120.965893808682174
DMSO vs. SAHA-0.02317457669512780.9216560855650640.981876243091941
HIV vs. Mock in Activation0.1163268368099480.8534731918965710.999983755607037
HIV vs. Mock in Latency0.03848357807807550.8155089068196860.999834320637052
IL7 vs. CD30.2814614428017010.383906370841270.52070734524345
SAHA vs. CD30.2738693801000210.441206025213930.55421978827823
SAHA vs. IL70.02250218433088690.9263365277407640.973072949070681
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) TRUE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -0.443885 0.000839432
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
retropepsin interacts with 22190034

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04150 mTOR signaling pathway - Homo sapiens (human)