Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0001082
UniProt IDQ9Y5Y0
Primary gene name(s)FLVCR1
Synonym gene name(s)FLVCR
Protein nameFeline leukemia virus subgroup C receptor-related protein 1
Protein functionIsoform 1: Heme transporter that exports cytoplasmic heme. It can also export coproporphyrin and protoporphyrin IX, which are both intermediate products in the heme biosynthetic pathway. Does not export bilirubin. Heme export depends on the presence of HPX and may be required to protect developing erythroid cells from heme toxicity. Heme export also provides protection from heme or ferrous iron toxicities in liver and brain. Causes susceptibility to FeLV-C in vitro. Required during erythtopoiesis to maintain intracellular free heme balance since in proerythroblasts, heme synthesis intensifies and it's accumulation is toxic for cells.; FUNCTION: Isoform 2: Heme transporter that promotes heme efflux from the mitochondrion to the cytoplasm. Essential for erythroid differentiation.
Subcellular locationIsoform 1: Cell membrane {ECO:0000250};
Multi-pass membrane protein {ECO:0000250}.;
SUBCELLULAR LOCATION: Isoform 2: Mitochondrion membrane {ECO:0000250};
Multi-pass membrane protein {ECO:0000250}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q9Y5Y0
Gene Ontology
(Biological Process)
Complete annatation
blood vessel development [GO:0001568];
cellular iron ion homeostasis [GO:0006879];
embryonic digit morphogenesis [GO:0042733];
embryonic skeletal system morphogenesis [GO:0048704];
erythrocyte differentiation [GO:0030218];
erythrocyte maturation [GO:0043249];
head morphogenesis [GO:0060323];
heme export [GO:0097037];
heme transport [GO:0015886];
in utero embryonic development [GO:0001701];
mitochondrial transport [GO:0006839];
multicellular organism development [GO:0007275];
multicellular organism growth [GO:0035264];
regulation of organ growth [GO:0046620];
spleen development [GO:0048536];
transmembrane transport [GO:0055085];
transport [GO:0006810]
Gene Ontology
(Molecular Function)
Complete annatation
heme transporter activity [GO:0015232];
transporter activity [GO:0005215]
Gene Ontology
(Cellular Component)
Complete annatation
integral component of plasma membrane [GO:0005887];
mitochondrial membrane [GO:0031966];
mitochondrion [GO:0005739];
plasma membrane [GO:0005886]
Protein-protein interaction118803
Phylogenetic treeQ9Y5Y0
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD31.199088629744920.0003199273064387050.0013424121276849
AZA vs. DISU0.2259744615640850.401373964150180.904456324173177
AZA vs. IL70.1040339315079540.5974795961778150.999311006273513
AZA vs. SAHA0.1362145748902970.5825749058986970.861545583392225
DISU vs. CD3-0.9850486097053040.007994763898839570.0240833475242022
DISU vs. IL7-0.1299108890539870.6199042041869040.88509594810144
DISU vs. SAHA-0.08938117473259380.7661014131285060.933624788265714
DMSO vs. AZA-0.009635764874594580.9556958509302251
DMSO vs. CD3-1.21822432171670.0001813600473540290.000762542314649301
DMSO vs. DISU-0.2365448937263480.3655053955186190.850082323454514
DMSO vs. IL70.1207002515347360.5128821657175060.88780433692056
DMSO vs. SAHA0.1377473698735060.5649962241228780.846483101228281
HIV vs. Mock in Activation0.001760301129877190.9977492493863170.999983755607037
HIV vs. Mock in Latency0.07928009493580510.642411342904540.999834320637052
IL7 vs. CD3-1.08646558244510.0008593146480091460.00372410859385907
SAHA vs. CD3-1.088177650287290.002415250625758090.00760983209913745
SAHA vs. IL70.02757082893615460.9111091544594130.966378356749286
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) TRUE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.444084 0.00302949
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
not found