Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0001080
UniProt IDQ8NFG4
Primary gene name(s)FLCN
Synonym gene name(s)BHD
Protein nameFolliculin
Protein functionMay be a tumor suppressor. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1. {ECO:0000269|PubMed:12204536, ECO:0000269|PubMed:17028174, ECO:0000269|PubMed:18663353}.
Subcellular locationCytoplasm {ECO:0000269|PubMed:17028174, ECO:0000269|PubMed:18663353}. Nucleus {ECO:0000269|PubMed:17028174, ECO:0000269|PubMed:18663353}. Note=Mainly localized in the nucleus. Colocalizes with FNIP1 and FNIP2 in the cytoplasm. {ECO:0000269|PubMed:17028174, ECO:0000269|PubMed:18663353}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q8NFG4
Gene Ontology
(Biological Process)
Complete annatation
cell-cell junction assembly [GO:0007043];
hemopoiesis [GO:0030097];
in utero embryonic development [GO:0001701];
negative regulation of ATP biosynthetic process [GO:2001170];
negative regulation of cell growth [GO:0030308];
negative regulation of cell migration [GO:0030336];
negative regulation of cell proliferation involved in kidney development [GO:1901723];
negative regulation of energy homeostasis [GO:2000506];
negative regulation of ERK1 and ERK2 cascade [GO:0070373];
negative regulation of gene expression [GO:0010629];
negative regulation of mitochondrion organization [GO:0010823];
negative regulation of protein kinase B signaling [GO:0051898];
negative regulation of protein localization to nucleus [GO:1900181];
negative regulation of Rho protein signal transduction [GO:0035024];
negative regulation of TOR signaling [GO:0032007];
negative regulation of transcription from RNA polymerase II promoter [GO:0000122];
positive regulation of apoptotic process [GO:0043065];
positive regulation of autophagy [GO:0010508];
positive regulation of cell adhesion [GO:0045785];
positive regulation of protein phosphorylation [GO:0001934];
positive regulation of TOR signaling [GO:0032008];
positive regulation of transcription from RNA polymerase II promoter [GO:0045944];
positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511];
regulation of cytokinesis [GO:0032465];
regulation of histone acetylation [GO:0035065];
regulation of pro-B cell differentiation [GO:2000973];
regulation of protein phosphorylation [GO:0001932];
regulation of TOR signaling [GO:0032006];
TOR signaling [GO:0031929]
Gene Ontology
(Molecular Function)
Complete annatation
guanyl-nucleotide exchange factor activity [GO:0005085];
protein complex binding [GO:0032403]
Gene Ontology
(Cellular Component)
Complete annatation
cytoplasm [GO:0005737];
lysosome [GO:0005764];
nucleus [GO:0005634];
plasma membrane [GO:0005886];
primary cilium [GO:0072372]
Protein-protein interaction128366
Phylogenetic treeQ8NFG4
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-0.1517738814897480.6434994278168710.740594332319478
AZA vs. DISU0.8699925164312730.0006748977461779050.0591066070095055
AZA vs. IL7-0.2041228506390150.2918094482474330.999311006273513
AZA vs. SAHA-0.3389744883562240.1670088536306430.521327699239658
DISU vs. CD31.007479703426660.006200132164529410.0194466900224961
DISU vs. IL7-1.082939378212372.2663486108021e-050.00165850511203115
DISU vs. SAHA-1.206857070117534.89651553982062e-050.00219629124109038
DMSO vs. AZA0.07512334112743040.6564867740211851
DMSO vs. CD30.211781562918960.5086147483381140.616087576080541
DMSO vs. DISU-0.7976404304091370.001201866748268940.0699310111830617
DMSO vs. IL7-0.2714427646357090.133986143477230.632122723648975
DMSO vs. SAHA-0.4194091653199910.07701887012419620.324129281531537
HIV vs. Mock in Activation0.1525499247704280.8066088547166250.999983755607037
HIV vs. Mock in Latency0.08021339312512790.6305852413161740.999834320637052
IL7 vs. CD3-0.0453360777369550.8880201374336630.928942156397918
SAHA vs. CD3-0.2119767525582660.5490084040388010.653152446512415
SAHA vs. IL7-0.1387260888317030.5709558241270980.777610055375125
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) TRUE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -0.184873 0.215356
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
0.826 0.934 1.184 1.174 1.003
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
3V42 X-ray 2.0Å A/B=341-566.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
retropepsin interacts with 22190034

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04150 mTOR signaling pathway - Homo sapiens (human)
hsa05211 Renal cell carcinoma - Homo sapiens (human)