Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0001079
UniProt IDQ02790
Primary gene name(s)FKBP4
Synonym gene name(s)FKBP52
Protein namePeptidyl-prolyl cis-trans isomerase FKBP4
Protein functionImmunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90, HSP90. May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria. {ECO:0000269|PubMed:1279700, ECO:0000269|PubMed:1376003, ECO:0000269|PubMed:19945390, ECO:0000269|PubMed:21730050, ECO:0000269|PubMed:2378870}.
Subcellular locationCytoplasm, cytosol {ECO:0000269|PubMed:2378870}. Mitochondrion {ECO:0000269|PubMed:21730050}. Nucleus {ECO:0000250|UniProtKB:P30416}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9QVC8}. Cell projection, axon {ECO:0000250|UniProtKB:Q9QVC8}. Note=Shuttles from mitochondria to nucleus;
co-localizes in mitochondria with the glucocorticoid receptor, PubMed:21730050. Colocalized with MAPT/TAU in the distal part of the primary cortical neurons, By similarity. {ECO:0000250|UniProtKB:Q9QVC8, ECO:0000269|PubMed:21730050}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q02790
Gene Ontology
(Biological Process)
Complete annatation
androgen receptor signaling pathway [GO:0030521];
chaperone-mediated protein folding [GO:0061077];
copper ion transport [GO:0006825];
embryo implantation [GO:0007566];
male sex differentiation [GO:0046661];
negative regulation of microtubule polymerization [GO:0031115];
negative regulation of microtubule polymerization or depolymerization [GO:0031111];
negative regulation of neuron projection development [GO:0010977];
prostate gland development [GO:0030850];
protein complex localization [GO:0031503];
protein folding [GO:0006457];
regulation of cellular response to heat [GO:1900034];
steroid hormone receptor complex assembly [GO:0006463]
Gene Ontology
(Molecular Function)
Complete annatation
ATP binding [GO:0005524];
FK506 binding [GO:0005528];
GTP binding [GO:0005525];
heat shock protein binding [GO:0031072];
peptidyl-prolyl cis-trans isomerase activity [GO:0003755];
poly(A RNA binding [GO:0044822];
protein binding, bridging [GO:0030674]
Gene Ontology
(Cellular Component)
Complete annatation
axonal growth cone [GO:0044295];
cytoplasm [GO:0005737];
cytosol [GO:0005829];
endoplasmic reticulum membrane [GO:0005789];
extracellular exosome [GO:0070062];
microtubule [GO:0005874];
mitochondrion [GO:0005739];
neuronal cell body [GO:0043025];
nucleoplasm [GO:0005654];
perinuclear region of cytoplasm [GO:0048471];
protein complex [GO:0043234]
Protein-protein interaction108578
Phylogenetic treeQ02790
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD32.290593688644692.49323894863096e-114.8487867656472e-10
AZA vs. DISU0.4067351448898370.1086956684001550.653579050610225
AZA vs. IL70.5524802594120360.006869441458251190.267854052576551
AZA vs. SAHA0.5613445713615060.02196520583697640.163993815149372
DISU vs. CD3-1.896354639586224.53553299029075e-074.76506859788706e-06
DISU vs. IL70.1366743165654590.5880960479017610.871454615964178
DISU vs. SAHA0.15629549039930.593044474094320.869302545383405
DMSO vs. AZA0.04213345869856440.8020047017267831
DMSO vs. CD3-2.26027716697011.49603662791264e-112.6830704523219e-10
DMSO vs. DISU-0.3665629746590040.1336724376950480.624074243817354
DMSO vs. IL70.5177476572880210.008179217535366210.188127956856358
DMSO vs. SAHA0.5130110324781860.03023712230701180.185471579279192
HIV vs. Mock in Activation0.02609186166190930.9665807605456240.999983755607037
HIV vs. Mock in Latency-0.1764024020169590.2883190041935350.999834320637052
IL7 vs. CD3-1.730780693906851.57310044213155e-071.84955873356075e-06
SAHA vs. CD3-1.753477005794661.35752250030041e-061.06551375414204e-05
SAHA vs. IL70.006262629049634790.9811105323976240.993434551310659
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) FALSE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.665181 0.000305467
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
0.978 0.97 0.938 0.88 0.914
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
1N1A X-ray 2.4Å A/B=1-140.
1P5Q X-ray 2.8Å A/B/C=146-459.
1Q1C X-ray 1.9Å A=2-260.
1QZ2 X-ray 3.0Å A/B/C=145-459.
4DRJ X-ray 1.8Å A=1-140.
4LAV X-ray 1.8Å A/B=16-260.
4LAW X-ray 2.4Å A/B=16-260.
4LAX X-ray 2.0Å A=16-260.
4LAY X-ray 1.7Å A=1-260.
4TW8 X-ray 3.0Å A/B=21-255.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
retropepsin cleaves 22944692
Tat upregulates 23166591
retropepsin interacts with 22190034

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04915 Estrogen signaling pathway - Homo sapiens (human)