Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0001076
UniProt IDP11362
Primary gene name(s)FGFR1
Synonym gene name(s)BFGFR, CEK, FGFBR, FLG, FLT2, HBGFR
Protein nameFibroblast growth factor receptor 1
Protein functionTyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone, GnRH neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation. {ECO:0000250|UniProtKB:P16092, ECO:0000269|PubMed:10830168, ECO:0000269|PubMed:11353842, ECO:0000269|PubMed:12181353, ECO:0000269|PubMed:1379697, ECO:0000269|PubMed:1379698, ECO:0000269|PubMed:15117958, ECO:0000269|PubMed:16597617, ECO:0000269|PubMed:17311277, ECO:0000269|PubMed:17623664, ECO:0000269|PubMed:18480409, ECO:0000269|PubMed:19224897, ECO:0000269|PubMed:19261810, ECO:0000269|PubMed:19665973, ECO:0000269|PubMed:20133753, ECO:0000269|PubMed:20139426, ECO:0000269|PubMed:21765395, ECO:0000269|PubMed:8622701, ECO:0000269|PubMed:8663044}.
Subcellular locationCell membrane;
Single-pass type I membrane protein. Nucleus. Cytoplasm, cytosol. Cytoplasmic vesicle. Note=After ligand binding, both receptor and ligand are rapidly internalized. Can translocate to the nucleus after internalization, or by translocation from the endoplasmic reticulum or Golgi apparatus to the cytosol, and from there to the nucleus.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P11362
Gene Ontology
(Biological Process)
Complete annatation
angiogenesis [GO:0001525];
auditory receptor cell development [GO:0060117];
branching involved in salivary gland morphogenesis [GO:0060445];
cell maturation [GO:0048469];
cell migration [GO:0016477];
chondrocyte differentiation [GO:0002062];
chordate embryonic development [GO:0043009];
embryonic limb morphogenesis [GO:0030326];
fibroblast growth factor receptor signaling pathway [GO:0008543];
fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development [GO:0035607];
inner ear morphogenesis [GO:0042472];
in utero embryonic development [GO:0001701];
lung-associated mesenchyme development [GO:0060484];
MAPK cascade [GO:0000165];
mesenchymal cell differentiation [GO:0048762];
midbrain development [GO:0030901];
middle ear morphogenesis [GO:0042474];
negative regulation of fibroblast growth factor production [GO:0090272];
negative regulation of transcription from RNA polymerase II promoter [GO:0000122];
neuron migration [GO:0001764];
organ induction [GO:0001759];
outer ear morphogenesis [GO:0042473];
paraxial mesoderm development [GO:0048339];
peptidyl-tyrosine phosphorylation [GO:0018108];
phosphatidylinositol-mediated signaling [GO:0048015];
positive regulation of cardiac muscle cell proliferation [GO:0060045];
positive regulation of cell proliferation [GO:0008284];
positive regulation of endothelial cell chemotaxis to fibroblast growth factor [GO:2000546];
positive regulation of MAPK cascade [GO:0043410];
positive regulation of MAP kinase activity [GO:0043406];
positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway [GO:0090080];
positive regulation of mesenchymal cell proliferation [GO:0002053];
positive regulation of mitotic cell cycle DNA replication [GO:1903465];
positive regulation of neuron differentiation [GO:0045666];
positive regulation of neuron projection development [GO:0010976];
positive regulation of parathyroid hormone secretion [GO:2000830];
positive regulation of phosphatidylinositol 3-kinase signaling [GO:0014068];
positive regulation of phospholipase activity [GO:0010518];
positive regulation of phospholipase C activity [GO:0010863];
protein autophosphorylation [GO:0046777];
protein phosphorylation [GO:0006468];
regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling [GO:0060665];
regulation of cell differentiation [GO:0045595];
regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001239];
regulation of lateral mesodermal cell fate specification [GO:0048378];
regulation of phosphatidylinositol 3-kinase signaling [GO:0014066];
sensory perception of sound [GO:0007605];
skeletal system development [GO:0001501];
skeletal system morphogenesis [GO:0048705];
transcription, DNA-templated [GO:0006351];
ureteric bud development [GO:0001657];
vacuolar phosphate transport [GO:0007037];
ventricular zone neuroblast division [GO:0021847];
vitamin D3 metabolic process [GO:0070640]
Gene Ontology
(Molecular Function)
Complete annatation
1-phosphatidylinositol-3-kinase activity [GO:0016303];
ATP binding [GO:0005524];
fibroblast growth factor-activated receptor activity [GO:0005007];
fibroblast growth factor binding [GO:0017134];
heparin binding [GO:0008201];
identical protein binding [GO:0042802];
phosphatidylinositol-4,5-bisphosphate 3-kinase activity [GO:0046934];
protein homodimerization activity [GO:0042803];
protein tyrosine kinase activity [GO:0004713];
Ras guanyl-nucleotide exchange factor activity [GO:0005088]
Gene Ontology
(Cellular Component)
Complete annatation
cytoplasmic, membrane-bounded vesicle [GO:0016023];
cytosol [GO:0005829];
extracellular region [GO:0005576];
integral component of membrane [GO:0016021];
integral component of plasma membrane [GO:0005887];
nucleus [GO:0005634];
plasma membrane [GO:0005886];
receptor complex [GO:0043235]
Protein-protein interaction108551
Phylogenetic treeP11362
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD30.6832024109546740.04196668077552690.0861981211023087
AZA vs. DISU-0.246787062473630.4877632896790.931429104131977
AZA vs. IL7-0.2786378433115340.2533506772868850.999311006273513
AZA vs. SAHA1.946819855260125.66293064985235e-060.000420507471014159
DISU vs. CD3-0.9437369650335350.01284723249554690.0357761934891029
DISU vs. IL7-0.03933547098578840.907039719713730.982189124739072
DISU vs. SAHA2.194786655255251.4851029542462e-050.000886895304138482
DMSO vs. AZA0.08411126664730180.7597041282165671
DMSO vs. CD3-0.6177966056710520.05895930309464680.110640495904441
DMSO vs. DISU0.3272798096809530.3574274497795830.845859244374735
DMSO vs. IL7-0.3541973258678450.1488714218210730.650880708802979
DMSO vs. SAHA1.856721517400511.34651548425735e-050.000717078970432597
HIV vs. Mock in Activation-0.3423188587916990.5850280020001010.999983755607037
HIV vs. Mock in Latency-0.4561596323899450.01661058065389190.461119507876181
IL7 vs. CD3-0.9527791416652840.003986542200357430.0138709950567838
SAHA vs. CD31.236726971846790.002237656808350420.00713093359318401
SAHA vs. IL72.220245236088671.07379951486131e-076.94697591717568e-06
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander 0.858 8.95E-09 3.39E-07
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) TRUE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -1.05456 0.000305467
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
0.909 1.331 0.73 0.617 1.584
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

Drugbank ID Drug Name Drug Status Pharmacological Action Drug Action
DB00039 Palifermin approved unknown unknown
DB05014 XL999 investigational unknown unknown
DB07525 3-(3-methoxybenzyl)-1H-pyrrolo[2,3-b]pyridine experimental unknown unknown
DB07840 (E)-[4-(3,5-difluorophenyl)-3H-pyrrolo[2,3-b]pyridin-3-ylidene](3-methoxyphenyl)methanol experimental unknown unknown
DB08577 3-[(3-(2-CARBOXYETHYL)-4-METHYLPYRROL-2-YL)METHYLENE]-2-INDOLINONE experimental unknown unknown
DB02058 SU4984 experimental unknown unknown
DB08896 Regorafenib approved yes inhibitor
DB08901 Ponatinib approved unknown inhibitor
DB00398 Sorafenib approved, investigational yes inhibitor
DB09078 Lenvatinib approved yes Inhibitor
DB09079 Nintedanib approved yes Inhibitor

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
1AGW X-ray 2.4Å A/B=456-765.
1CVS X-ray 2.8Å C/D=141-365.
1EVT X-ray 2.8Å C/D=141-365.
1FGI X-ray 2.5Å A/B=456-765.
1FGK X-ray 2.0Å A/B=456-765.
1FQ9 X-ray 3.0Å C/D=141-365.
1XR0 NMR - A=409-430.
2CR3 NMR - A=38-123.
2FGI X-ray 2.5Å A/B=456-765.
3C4F X-ray 2.0Å A/B=464-765.
3DPK X-ray 1.9Å A=577-615.
3GQI X-ray 2.5Å A=458-774.
3GQL X-ray 2.8Å A/B/C=458-774.
3JS2 X-ray 2.2Å A/B=458-765.
3KRJ X-ray 2.1Å A=577-597.
3KRL X-ray 2.4Å A=577-597.
3KXX X-ray 3.2Å A/B/C/D=458-765.
3KY2 X-ray 2.7Å A/B=458-765.
3OJV X-ray 2.6Å C/D=142-365.
3RHX X-ray 2.0Å A/B=461-765.
3TT0 X-ray 2.8Å A/B=456-765.
4F63 X-ray 2.5Å A/B=458-765.
4F64 X-ray 2.0Å A/B=458-765.
4F65 X-ray 2.2Å A/B=458-765.
4NK9 X-ray 2.5Å A/B=458-765.
4NKA X-ray 2.1Å A/B=458-765.
4NKS X-ray 2.5Å A/B=458-765.
4RWI X-ray 2.2Å A/B=458-765.
4RWJ X-ray 2.4Å A/B=458-765.
4RWK X-ray 2.9Å A/B=458-765.
4RWL X-ray 2.1Å A/B=458-765.
4UWB X-ray 2.3Å A/B=458-765.
4UWC X-ray 1.9Å A/B=458-765.
4UWY X-ray 2.3Å A/B=458-765.
4V01 X-ray 2.3Å A/B=458-765.
4V04 X-ray 2.1Å A/B=458-765.
4V05 X-ray 2.5Å A/B=458-765.
4WUN X-ray 1.6Å A/B=459-765.
4ZSA X-ray 2.0Å A/B=458-765.
5A46 X-ray 2.6Å A/B=437-822.
5A4C X-ray 2.0Å A/B=461-765.
5AM6 X-ray 1.9Å A/B=458-765.
5AM7 X-ray 1.9Å A/B=458-765.
5B7V X-ray 2.1Å A/B=456-765.
5EW8 X-ray 1.6Å A/B=458-765.
5FLF X-ray 2.5Å A/B/C/D/E=458-765.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04010 MAPK signaling pathway - Homo sapiens (human)
hsa04014 Ras signaling pathway - Homo sapiens (human)
hsa04015 Rap1 signaling pathway - Homo sapiens (human)
hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
hsa04520 Adherens junction - Homo sapiens (human)
hsa04550 Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)
hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human)
hsa05200 Pathways in cancer - Homo sapiens (human)
hsa05205 Proteoglycans in cancer - Homo sapiens (human)
hsa05215 Prostate cancer - Homo sapiens (human)
hsa05218 Melanoma - Homo sapiens (human)
hsa05224 Breast cancer - Homo sapiens (human)
hsa05230 Central carbon metabolism in cancer - Homo sapiens (human)