Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0001049
UniProt IDO15287
Primary gene name(s)FANCG
Synonym gene name(s)XRCC9
Protein nameFanconi anemia group G protein
Protein functionDNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Candidate tumor suppressor gene.
Subcellular locationNucleus {ECO:0000269|PubMed:18550849}. Cytoplasm {ECO:0000269|PubMed:18550849}. Note=The major form is nuclear. The minor form is cytoplasmic.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: O15287
Gene Ontology
(Biological Process)
Complete annatation
cell cycle checkpoint [GO:0000075];
DNA repair [GO:0006281];
interstrand cross-link repair [GO:0036297];
mitochondrion organization [GO:0007005];
ovarian follicle development [GO:0001541];
response to radiation [GO:0009314];
spermatid development [GO:0007286]
Gene Ontology
(Molecular Function)
Complete annatation
damaged DNA binding [GO:0003684]
Gene Ontology
(Cellular Component)
Complete annatation
cytoplasm [GO:0005737];
Fanconi anaemia nuclear complex [GO:0043240];
mitochondrion [GO:0005739];
nucleolus [GO:0005730];
nucleoplasm [GO:0005654];
plasma membrane [GO:0005886]
Protein-protein interaction108484
Phylogenetic treeO15287
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD30.9340812590684910.1985473443852830.303227984410646
AZA vs. DISU0.2653480136185760.3440923302459380.883318764667451
AZA vs. IL70.03924309042979510.8811855295991890.999311006273513
AZA vs. SAHA0.6022271484487030.0188956546647120.148196201048839
DISU vs. CD3-0.6829914924337470.3519001037198910.485674982921959
DISU vs. IL7-0.2352645067818540.5127456594008290.833246096543715
DISU vs. SAHA0.3401780427405360.3535371717344250.730785724209233
DMSO vs. AZA-0.03476171100639690.8420368202830341
DMSO vs. CD3-0.9824382980367510.1765935515196850.271052659566384
DMSO vs. DISU-0.3024946413603940.275981508976120.794013237928623
DMSO vs. IL70.08157331432533680.7538251579881570.951631847120623
DMSO vs. SAHA0.6322484432689720.01178831574609950.100247628140157
HIV vs. Mock in Activation0.1990958372375450.8933582340694810.999983755607037
HIV vs. Mock in Latency0.1583591378944860.3535307064714420.999834320637052
IL7 vs. CD3-0.8891890712618790.2277505860866760.356263444109187
SAHA vs. CD3-0.3551889122700150.666063807667030.751935094879177
SAHA vs. IL70.5616431995537370.1189564266850320.31883875815259
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) TRUE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.437222 0.000839432
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
203564_at 1.58 No upregulated in CD8+ cells

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa03460 Fanconi anemia pathway - Homo sapiens (human)