Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0000984
UniProt IDP41162
Primary gene name(s)ETV3
Synonym gene name(s)METS, PE1
Protein nameETS translocation variant 3
Protein functionTranscriptional repressor that contribute to growth arrest during terminal macrophage differentiation by repressing target genes involved in Ras-dependent proliferation. Represses MMP1 promoter activity. {ECO:0000269|PubMed:12007404}.
Subcellular locationNucleus {ECO:0000255|PROSITE-ProRule:PRU00237}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P41162
Gene Ontology
(Biological Process)
Complete annatation
cell differentiation [GO:0030154];
cellular response to granulocyte macrophage colony-stimulating factor stimulus [GO:0097011];
negative regulation of cell proliferation [GO:0008285];
regulation of transcription from RNA polymerase II promoter [GO:0006357];
transcription, DNA-templated [GO:0006351]
Gene Ontology
(Molecular Function)
Complete annatation
RNA polymerase II regulatory region sequence-specific DNA binding [GO:0000977];
RNA polymerase II transcription factor activity, sequence-specific DNA binding [GO:0000981];
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding [GO:0001227]
Gene Ontology
(Cellular Component)
Complete annatation
nuclear chromatin [GO:0000790];
nucleus [GO:0005634];
RNA polymerase II transcription repressor complex [GO:0090571]
Protein-protein interaction108418
Phylogenetic treeP41162
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
      Yes - Two siRNA pools inhibit HIV replication and inhibition of Tat-mediated transactivation of the HIV LTR is not observed
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-0.269064340745210.4212866613887350.542842828114132
AZA vs. DISU-0.2783810383524060.2715450962447930.845621663457437
AZA vs. IL70.3344088800544220.08231015980861090.792807883894659
AZA vs. SAHA0.0859024138604410.7255667343965330.923428568543383
DISU vs. CD3-0.02071798183671420.9550875783048020.970797206537591
DISU vs. IL70.60339608479210.01692519944730610.161485684600088
DISU vs. SAHA0.3656715175537910.2126656328988230.587234306066362
DMSO vs. AZA-0.04076613501360570.8079332153273331
DMSO vs. CD30.2215081464627740.5155183533841660.622511031231558
DMSO vs. DISU0.236985911437620.3315750189606160.832624925724678
DMSO vs. IL70.3818771903951850.03389997476868160.377431402982182
DMSO vs. SAHA0.118937039699640.615631649763260.873485796750334
HIV vs. Mock in Activation0.2220085149429160.7578187932198890.999983755607037
HIV vs. Mock in Latency-0.1024853040603090.7868362856596760.999834320637052
IL7 vs. CD30.610538935772270.0619439801066410.130457120601844
SAHA vs. CD30.3308145767175420.3761572666513060.492801009165885
SAHA vs. IL7-0.2513927469487190.3049422628775820.553814166461005
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) TRUE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -0.127976 0.500026
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
0.677 0.618 0.813 0.789 0.607
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
HIV-1 virus replication enhanced by expression of human gene 18976975

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
not found