Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0000978
UniProt IDQ86YB8
Primary gene name(s)ERO1B
Synonym gene name(s)ERO1LB
Protein nameERO1-like protein beta
Protein functionOxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Other protein disulfide isomerase family members can also be reoxidized, but at lower rates compared to P4HB, including PDIA2, 50% of P4HB reoxidation rate, as well as PDIA3, PDIA4, PDIA6 and NXNDC12, <10%. Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species, ROS in the cell. May be involved in oxidative proinsulin folding in pancreatic cells, hence may play a role in glucose homeostasis. {ECO:0000269|PubMed:11707400, ECO:0000269|PubMed:21091435}.
Subcellular locationEndoplasmic reticulum membrane {ECO:0000269|PubMed:10818100};
Peripheral membrane protein {ECO:0000269|PubMed:10818100};
Lumenal side {ECO:0000269|PubMed:10818100}. Note=The association with ERP44 may be essential for its retention in the endoplasmic reticulum.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q86YB8
Gene Ontology
(Biological Process)
Complete annatation
4-hydroxyproline metabolic process [GO:0019471];
cell redox homeostasis [GO:0045454];
cellular protein modification process [GO:0006464];
extracellular matrix organization [GO:0030198];
glucose homeostasis [GO:0042593];
insulin processing [GO:0030070];
protein folding [GO:0006457];
protein folding in endoplasmic reticulum [GO:0034975];
protein maturation by protein folding [GO:0022417]
Gene Ontology
(Molecular Function)
Complete annatation
unknown
Gene Ontology
(Cellular Component)
Complete annatation
unknown
Protein-protein interaction121155
Phylogenetic treeQ86YB8
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
      unknown
Brass et al., Science, 2008
      unknown
Smith et al., J. Immunol, 2010
      unknown
Interferon-stimulated
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model


DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD30.2593864389448150.4309690539296310.552250091891463
AZA vs. DISU0.6615078235495130.252855119670170.834111717141601
AZA vs. IL7-0.502397639187680.01240400650256280.370228891115107
AZA vs. SAHA0.4903625138994670.0476043695687910.262728398425785
DISU vs. CD30.3886340981935880.4863097761024170.613442139327852
DISU vs. IL7-1.171026431814810.0419905267961780.270747301733269
DISU vs. SAHA-0.1705626801070240.7681189987281810.934327799017951
DMSO vs. AZA-0.0489706119520260.7769626392752511
DMSO vs. CD3-0.3219168462275990.3169501079784160.429354678238903
DMSO vs. DISU-0.712505129592130.207196008983580.721324014996986
DMSO vs. IL7-0.4461204916246060.01616646419645570.265393540316242
DMSO vs. SAHA0.5316519269371570.02627072726641330.169054709919776
HIV vs. Mock in Activation-0.2985600374252250.6326618915006330.999983755607037
HIV vs. Mock in Latency-0.2139592262892360.2051476064564790.999834320637052
IL7 vs. CD3-0.7513561071657430.02083858935046510.0540247776538632
SAHA vs. CD30.2047690732918370.5639432809149390.666506567593768
SAHA vs. IL70.9872595864412397.53488179973116e-050.0015495335368233
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) TRUE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.312664 0.12694
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

Drugbank ID Drug Name Drug Status Pharmacological Action Drug Action
DB01902 1-Ethyl-Pyrrolidine-2,5-Dione experimental unknown unknown
DB03147 Flavin adenine dinucleotide approved unknown unknown

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04141 Protein processing in endoplasmic reticulum - Homo sapiens (human)
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